Case of Non-Langerhans Cell Histiocytosis in a Person Living with HIV - Clinical and Therapeutic Challenge
Non-Langerhans cell histiocytosis is a rare disease which seldom affects adults. We report a case of a 32-year-old Bulgarian woman living with HIV. She developed severe anemia, extreme splenomegaly, requiring splenectomy and vertebral tumor formations leading to fracture. The diagnosis was confirmed...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-06-01
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| Series: | Journal of the International Association of Providers of AIDS Care |
| Online Access: | https://doi.org/10.1177/23259582221109567 |
| _version_ | 1828197631107530752 |
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| author | Nina Yancheva Dimitar Strashimirov Dragomir Dardanov Bojidar Kamenov Atanas Radinoff |
| author_facet | Nina Yancheva Dimitar Strashimirov Dragomir Dardanov Bojidar Kamenov Atanas Radinoff |
| author_sort | Nina Yancheva |
| collection | DOAJ |
| description | Non-Langerhans cell histiocytosis is a rare disease which seldom affects adults. We report a case of a 32-year-old Bulgarian woman living with HIV. She developed severe anemia, extreme splenomegaly, requiring splenectomy and vertebral tumor formations leading to fracture. The diagnosis was confirmed by histological examination of the spleen, but subsequently questioned and a cumulative disease was discussed. After genetic testing, a cumulative disease was ruled out and the condition was determined to be Non-Langerhans cell histiocytosis. According to literature data, the disease has a high mortality rate. However, in our case, we should also note that there was a delay in diagnosis by several months due to difficulties in the clarification of the hematological disorder. |
| first_indexed | 2024-04-12T10:22:51Z |
| format | Article |
| id | doaj.art-95482fb69cec4e3481320bf06bd7b1a9 |
| institution | Directory Open Access Journal |
| issn | 2325-9582 |
| language | English |
| last_indexed | 2024-04-12T10:22:51Z |
| publishDate | 2022-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of the International Association of Providers of AIDS Care |
| spelling | doaj.art-95482fb69cec4e3481320bf06bd7b1a92022-12-22T03:37:02ZengSAGE PublishingJournal of the International Association of Providers of AIDS Care2325-95822022-06-012110.1177/23259582221109567Case of Non-Langerhans Cell Histiocytosis in a Person Living with HIV - Clinical and Therapeutic ChallengeNina Yancheva0Dimitar Strashimirov1Dragomir Dardanov2Bojidar Kamenov3Atanas Radinoff4 Department of AIDS, Prof. Ivan Kirov Specialized Hospital for Active Тreatment of Infectious and Parasitic Diseases Medical University – Sofia, Bulgaria Department of AIDS, Prof. Ivan Kirov Specialized Hospital for Active Тreatment of Infectious and Parasitic Diseases Medical University – Sofia, Bulgaria First Surgical Clinic, Aleksandrovska University Multidisciplinary Hospital, Medical University – Sofia, Bulgaria Neurosurgical clinic, St.Ivan Rilski University Multidisciplinary Hospital, Bulgaria Clinic of Haematology, St.Ivan Rilski University Multidisciplinary Hospital, BulgariaNon-Langerhans cell histiocytosis is a rare disease which seldom affects adults. We report a case of a 32-year-old Bulgarian woman living with HIV. She developed severe anemia, extreme splenomegaly, requiring splenectomy and vertebral tumor formations leading to fracture. The diagnosis was confirmed by histological examination of the spleen, but subsequently questioned and a cumulative disease was discussed. After genetic testing, a cumulative disease was ruled out and the condition was determined to be Non-Langerhans cell histiocytosis. According to literature data, the disease has a high mortality rate. However, in our case, we should also note that there was a delay in diagnosis by several months due to difficulties in the clarification of the hematological disorder.https://doi.org/10.1177/23259582221109567 |
| spellingShingle | Nina Yancheva Dimitar Strashimirov Dragomir Dardanov Bojidar Kamenov Atanas Radinoff Case of Non-Langerhans Cell Histiocytosis in a Person Living with HIV - Clinical and Therapeutic Challenge Journal of the International Association of Providers of AIDS Care |
| title | Case of Non-Langerhans Cell Histiocytosis
in a Person Living with HIV - Clinical
and Therapeutic Challenge |
| title_full | Case of Non-Langerhans Cell Histiocytosis
in a Person Living with HIV - Clinical
and Therapeutic Challenge |
| title_fullStr | Case of Non-Langerhans Cell Histiocytosis
in a Person Living with HIV - Clinical
and Therapeutic Challenge |
| title_full_unstemmed | Case of Non-Langerhans Cell Histiocytosis
in a Person Living with HIV - Clinical
and Therapeutic Challenge |
| title_short | Case of Non-Langerhans Cell Histiocytosis
in a Person Living with HIV - Clinical
and Therapeutic Challenge |
| title_sort | case of non langerhans cell histiocytosis in a person living with hiv clinical and therapeutic challenge |
| url | https://doi.org/10.1177/23259582221109567 |
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