Lymphatic and Blood Endothelial Extracellular Vesicles: A Story Yet to Be Written
Extracellular vesicles (EVs), such as exosomes, microvesicles, and apoptotic bodies, are cell-derived, lipid bilayer-enclosed particles mediating intercellular communication and are therefore vital for transmitting a plethora of biological signals. The vascular endothelium substantially contributes...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/5/654 |
| _version_ | 1827668289815314432 |
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| author | Johanna Trisko Johanna Fleck Silvio Kau Johannes Oesterreicher Wolfgang Holnthoner |
| author_facet | Johanna Trisko Johanna Fleck Silvio Kau Johannes Oesterreicher Wolfgang Holnthoner |
| author_sort | Johanna Trisko |
| collection | DOAJ |
| description | Extracellular vesicles (EVs), such as exosomes, microvesicles, and apoptotic bodies, are cell-derived, lipid bilayer-enclosed particles mediating intercellular communication and are therefore vital for transmitting a plethora of biological signals. The vascular endothelium substantially contributes to the circulating particulate secretome, targeting important signaling pathways that affect blood cells and regulate adaptation and plasticity of endothelial cells in a paracrine manner. Different molecular signatures and functional properties of endothelial cells reflect their heterogeneity among different vascular beds and drive current research to understand varying physiological and pathological effects of blood and lymphatic endothelial EVs. Endothelial EVs have been linked to the development and progression of various vascular diseases, thus having the potential to serve as biomarkers and clinical treatment targets. This review aims to provide a brief overview of the human vasculature, the biology of extracellular vesicles, and the current knowledge of endothelium-derived EVs, including their potential role as biomarkers in disease development. |
| first_indexed | 2024-03-10T03:33:57Z |
| format | Article |
| id | doaj.art-9548c1ca03a84a96806c5f6ab66a0582 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T03:33:57Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-9548c1ca03a84a96806c5f6ab66a05822023-11-23T11:49:26ZengMDPI AGLife2075-17292022-04-0112565410.3390/life12050654Lymphatic and Blood Endothelial Extracellular Vesicles: A Story Yet to Be WrittenJohanna Trisko0Johanna Fleck1Silvio Kau2Johannes Oesterreicher3Wolfgang Holnthoner4Ludwig-Boltzmann-Institute for Traumatology, The Research Center in Cooperation with AUVA, A-1200 Vienna, AustriaLudwig-Boltzmann-Institute for Traumatology, The Research Center in Cooperation with AUVA, A-1200 Vienna, AustriaLudwig-Boltzmann-Institute for Traumatology, The Research Center in Cooperation with AUVA, A-1200 Vienna, AustriaLudwig-Boltzmann-Institute for Traumatology, The Research Center in Cooperation with AUVA, A-1200 Vienna, AustriaLudwig-Boltzmann-Institute for Traumatology, The Research Center in Cooperation with AUVA, A-1200 Vienna, AustriaExtracellular vesicles (EVs), such as exosomes, microvesicles, and apoptotic bodies, are cell-derived, lipid bilayer-enclosed particles mediating intercellular communication and are therefore vital for transmitting a plethora of biological signals. The vascular endothelium substantially contributes to the circulating particulate secretome, targeting important signaling pathways that affect blood cells and regulate adaptation and plasticity of endothelial cells in a paracrine manner. Different molecular signatures and functional properties of endothelial cells reflect their heterogeneity among different vascular beds and drive current research to understand varying physiological and pathological effects of blood and lymphatic endothelial EVs. Endothelial EVs have been linked to the development and progression of various vascular diseases, thus having the potential to serve as biomarkers and clinical treatment targets. This review aims to provide a brief overview of the human vasculature, the biology of extracellular vesicles, and the current knowledge of endothelium-derived EVs, including their potential role as biomarkers in disease development.https://www.mdpi.com/2075-1729/12/5/654vasculaturevascular endothelial cellexosomemicrovesicleapoptotic bodyEV biogenesis |
| spellingShingle | Johanna Trisko Johanna Fleck Silvio Kau Johannes Oesterreicher Wolfgang Holnthoner Lymphatic and Blood Endothelial Extracellular Vesicles: A Story Yet to Be Written Life vasculature vascular endothelial cell exosome microvesicle apoptotic body EV biogenesis |
| title | Lymphatic and Blood Endothelial Extracellular Vesicles: A Story Yet to Be Written |
| title_full | Lymphatic and Blood Endothelial Extracellular Vesicles: A Story Yet to Be Written |
| title_fullStr | Lymphatic and Blood Endothelial Extracellular Vesicles: A Story Yet to Be Written |
| title_full_unstemmed | Lymphatic and Blood Endothelial Extracellular Vesicles: A Story Yet to Be Written |
| title_short | Lymphatic and Blood Endothelial Extracellular Vesicles: A Story Yet to Be Written |
| title_sort | lymphatic and blood endothelial extracellular vesicles a story yet to be written |
| topic | vasculature vascular endothelial cell exosome microvesicle apoptotic body EV biogenesis |
| url | https://www.mdpi.com/2075-1729/12/5/654 |
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