Electroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trial
Background: The first treatment option for major depressive disorder (MDD) is antidepressants, however, there is substantial demand for alternative therapies due to its low compliance and remission rates. This study was aimed to explore the effectiveness, safety, and feasibility of electroacupunctur...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422021000147 |
| _version_ | 1818582493129867264 |
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| author | Mikyung Kim Eun-Ji Choi O-Jin Kwon Hyo-Ju Park Ae-Ran Kim Bok-Nam Seo Sun-Yong Chung Jun-Hwan Lee Joo-Hee Kim |
| author_facet | Mikyung Kim Eun-Ji Choi O-Jin Kwon Hyo-Ju Park Ae-Ran Kim Bok-Nam Seo Sun-Yong Chung Jun-Hwan Lee Joo-Hee Kim |
| author_sort | Mikyung Kim |
| collection | DOAJ |
| description | Background: The first treatment option for major depressive disorder (MDD) is antidepressants, however, there is substantial demand for alternative therapies due to its low compliance and remission rates. This study was aimed to explore the effectiveness, safety, and feasibility of electroacupuncture plus moxibustion therapy for MDD. Methods: Thirty adults with MDD were randomly assigned to the treatment group (TG) or control group (CG). The TG was treated with electroacupuncture plus moxibustion, and the CG received sham interventions at non-acupoints for 8 weeks. The primary outcome measure was the intergroup difference of the mean change of total score of the Hamilton rating scale for depression (HRSD) between baseline and week 9. Secondary outcome measures were Beck's depression inventory, insomnia severity index, the state-trait anxiety inventory, the EuroQol-5 dimension index, the measure yourself medical outcome profile version 2, and frontal alpha asymmetry measured by electroencephalography. Adverse events (AEs) were monitored for safety assessment. Results: The primary outcome measure was not significantly different between the two groups (p=0.2641), although the scores of HRSD in both groups improved significantly after treatment. No significant difference was identified between groups in secondary outcome measures. The incidence of AE was not significantly different between the two groups (p=0.1067). Conclusion: A clinical trial using electroacupuncture plus moxibustion for MDD seems feasible. However, further studies with the larger size, adopting ideal controls are warranted to provide a confirmative conclusion to the efficacy and safety of electroacupuncture plus moxibustion for MDD. |
| first_indexed | 2024-12-16T07:50:15Z |
| format | Article |
| id | doaj.art-95491f5a6ece47498f05a4b315137174 |
| institution | Directory Open Access Journal |
| issn | 2213-4220 |
| language | English |
| last_indexed | 2024-12-16T07:50:15Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj.art-95491f5a6ece47498f05a4b3151371742022-12-21T22:38:52ZengElsevierIntegrative Medicine Research2213-42202021-09-01103100727Electroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trialMikyung Kim0Eun-Ji Choi1O-Jin Kwon2Hyo-Ju Park3Ae-Ran Kim4Bok-Nam Seo5Sun-Yong Chung6Jun-Hwan Lee7Joo-Hee Kim8Department of Internal Medicine, College of Korean Medicine, Sangji University, Wonju, Republic of KoreaHaneum Neuropsychiatry Clinic of Korean Medicine, Cheonan, Republic of KoreaClinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of KoreaClinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of KoreaClinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of KoreaClinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of KoreaDepartment of Neuropsychiatry, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaClinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea; Korean Convergence Medicine, University of Science & Technology (UST), Daejeon, Republic of Korea; Corresponding authors.Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Sangji University, Wonju, Republic of Korea; Research institute of Korean medicine, Sangji University, Wonju, Republic of Korea; Corresponding authors.Background: The first treatment option for major depressive disorder (MDD) is antidepressants, however, there is substantial demand for alternative therapies due to its low compliance and remission rates. This study was aimed to explore the effectiveness, safety, and feasibility of electroacupuncture plus moxibustion therapy for MDD. Methods: Thirty adults with MDD were randomly assigned to the treatment group (TG) or control group (CG). The TG was treated with electroacupuncture plus moxibustion, and the CG received sham interventions at non-acupoints for 8 weeks. The primary outcome measure was the intergroup difference of the mean change of total score of the Hamilton rating scale for depression (HRSD) between baseline and week 9. Secondary outcome measures were Beck's depression inventory, insomnia severity index, the state-trait anxiety inventory, the EuroQol-5 dimension index, the measure yourself medical outcome profile version 2, and frontal alpha asymmetry measured by electroencephalography. Adverse events (AEs) were monitored for safety assessment. Results: The primary outcome measure was not significantly different between the two groups (p=0.2641), although the scores of HRSD in both groups improved significantly after treatment. No significant difference was identified between groups in secondary outcome measures. The incidence of AE was not significantly different between the two groups (p=0.1067). Conclusion: A clinical trial using electroacupuncture plus moxibustion for MDD seems feasible. However, further studies with the larger size, adopting ideal controls are warranted to provide a confirmative conclusion to the efficacy and safety of electroacupuncture plus moxibustion for MDD.http://www.sciencedirect.com/science/article/pii/S2213422021000147Major depressive disorderElectroacupunctureMoxibustionRandomized controlled trial |
| spellingShingle | Mikyung Kim Eun-Ji Choi O-Jin Kwon Hyo-Ju Park Ae-Ran Kim Bok-Nam Seo Sun-Yong Chung Jun-Hwan Lee Joo-Hee Kim Electroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trial Integrative Medicine Research Major depressive disorder Electroacupuncture Moxibustion Randomized controlled trial |
| title | Electroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trial |
| title_full | Electroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trial |
| title_fullStr | Electroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trial |
| title_full_unstemmed | Electroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trial |
| title_short | Electroacupuncture plus moxibustion for major depressive disorder: A randomized, sham-controlled, pilot clinical trial |
| title_sort | electroacupuncture plus moxibustion for major depressive disorder a randomized sham controlled pilot clinical trial |
| topic | Major depressive disorder Electroacupuncture Moxibustion Randomized controlled trial |
| url | http://www.sciencedirect.com/science/article/pii/S2213422021000147 |
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