Hospital-based study on emergency admission of patients with Parkinson's disease
Objective: Parkinson's disease (PD) is a progressive neurodegenerative disease. As the severity of disease worsens, patients have lower tolerance for treatments and occasionally need to be hospitalized. This study focuses on characteristics of patients with PD who were emergently admitted to ou...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-09-01
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| Series: | eNeurologicalSci |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405650216300223 |
| _version_ | 1818571082984062976 |
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| author | Shinsuke Fujioka Jiro Fukae Hiromu Ogura Takayasu Mishima Shozaburo Yanamoto Masa-aki Higuchi George Umemoto Yoshio Tsuboi |
| author_facet | Shinsuke Fujioka Jiro Fukae Hiromu Ogura Takayasu Mishima Shozaburo Yanamoto Masa-aki Higuchi George Umemoto Yoshio Tsuboi |
| author_sort | Shinsuke Fujioka |
| collection | DOAJ |
| description | Objective: Parkinson's disease (PD) is a progressive neurodegenerative disease. As the severity of disease worsens, patients have lower tolerance for treatments and occasionally need to be hospitalized. This study focuses on characteristics of patients with PD who were emergently admitted to our hospital and evaluates their prognosis during hospitalization.
Methods: Hospital-based study on emergency admission was conducted in a consecutive series of patients with PD between April 2009 and March 2015.
Results: A total of 164 admissions involving 136 patients with PD with available medical records were identified. Among these, 40 admissions involving 38 patients were emergency admissions. The most common cause of hospitalization was aspiration pneumonia (n = 17) followed by parkinsonism hyperpyrexia syndrome (n = 6), cerebrovascular disease (n = 2), dehydration (n = 2), and others (n = 13). The mean Hoehn and Yahr stage at admission and discharge were 3.5 and 4.2, respectively, with significant differences between time points (p < 0.001). All patients except one presented with either postural instability gait difficulty phenotype (PIGD) or mixed phenotype with PIGD and tremor. All 17 patients with aspiration pneumonia had various combinations of three components: abnormalities seen on videofluoroscopy swallowing study, cognitive impairment, and history of psychiatric symptoms.
Conclusion: Aspiration pneumonia was the most common reason for emergency admission in patients afflicted with PD for more than five years. Abnormalities seen in videofluoroscopy, PIGD and mixed phenotypes, cognitive impairment, and history of psychiatric symptoms could potentially be predictors for aspiration pneumonia in patients with PD. |
| first_indexed | 2024-12-14T13:50:50Z |
| format | Article |
| id | doaj.art-954ae480b5d442e1a46b5b52b66eb592 |
| institution | Directory Open Access Journal |
| issn | 2405-6502 |
| language | English |
| last_indexed | 2024-12-14T13:50:50Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | eNeurologicalSci |
| spelling | doaj.art-954ae480b5d442e1a46b5b52b66eb5922022-12-21T22:59:05ZengElseviereNeurologicalSci2405-65022016-09-014C192110.1016/j.ensci.2016.04.007Hospital-based study on emergency admission of patients with Parkinson's diseaseShinsuke Fujioka0Jiro Fukae1Hiromu Ogura2Takayasu Mishima3Shozaburo Yanamoto4Masa-aki Higuchi5George Umemoto6Yoshio Tsuboi7Department of Neurology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, Fukuoka 814-0180, JapanDepartment of Neurology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, Fukuoka 814-0180, JapanDepartment of Neurology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, Fukuoka 814-0180, JapanDepartment of Neurology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, Fukuoka 814-0180, JapanDepartment of Neurology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, Fukuoka 814-0180, JapanDepartment of Neurology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, Fukuoka 814-0180, JapanOral and Maxillofacial Surgery, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, Fukuoka 814-0180, JapanDepartment of Neurology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, Fukuoka 814-0180, JapanObjective: Parkinson's disease (PD) is a progressive neurodegenerative disease. As the severity of disease worsens, patients have lower tolerance for treatments and occasionally need to be hospitalized. This study focuses on characteristics of patients with PD who were emergently admitted to our hospital and evaluates their prognosis during hospitalization. Methods: Hospital-based study on emergency admission was conducted in a consecutive series of patients with PD between April 2009 and March 2015. Results: A total of 164 admissions involving 136 patients with PD with available medical records were identified. Among these, 40 admissions involving 38 patients were emergency admissions. The most common cause of hospitalization was aspiration pneumonia (n = 17) followed by parkinsonism hyperpyrexia syndrome (n = 6), cerebrovascular disease (n = 2), dehydration (n = 2), and others (n = 13). The mean Hoehn and Yahr stage at admission and discharge were 3.5 and 4.2, respectively, with significant differences between time points (p < 0.001). All patients except one presented with either postural instability gait difficulty phenotype (PIGD) or mixed phenotype with PIGD and tremor. All 17 patients with aspiration pneumonia had various combinations of three components: abnormalities seen on videofluoroscopy swallowing study, cognitive impairment, and history of psychiatric symptoms. Conclusion: Aspiration pneumonia was the most common reason for emergency admission in patients afflicted with PD for more than five years. Abnormalities seen in videofluoroscopy, PIGD and mixed phenotypes, cognitive impairment, and history of psychiatric symptoms could potentially be predictors for aspiration pneumonia in patients with PD.http://www.sciencedirect.com/science/article/pii/S2405650216300223Parkinson's diseaseEmergency admissionAspiration pneumoniaVideofluoroscopyCognitive impairmentPsychiatric symptoms |
| spellingShingle | Shinsuke Fujioka Jiro Fukae Hiromu Ogura Takayasu Mishima Shozaburo Yanamoto Masa-aki Higuchi George Umemoto Yoshio Tsuboi Hospital-based study on emergency admission of patients with Parkinson's disease eNeurologicalSci Parkinson's disease Emergency admission Aspiration pneumonia Videofluoroscopy Cognitive impairment Psychiatric symptoms |
| title | Hospital-based study on emergency admission of patients with Parkinson's disease |
| title_full | Hospital-based study on emergency admission of patients with Parkinson's disease |
| title_fullStr | Hospital-based study on emergency admission of patients with Parkinson's disease |
| title_full_unstemmed | Hospital-based study on emergency admission of patients with Parkinson's disease |
| title_short | Hospital-based study on emergency admission of patients with Parkinson's disease |
| title_sort | hospital based study on emergency admission of patients with parkinson s disease |
| topic | Parkinson's disease Emergency admission Aspiration pneumonia Videofluoroscopy Cognitive impairment Psychiatric symptoms |
| url | http://www.sciencedirect.com/science/article/pii/S2405650216300223 |
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