Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion

Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion

Epithelial fusion underlies many vital organogenic processes during embryogenesis. Disruptions to these cause a significant number of human birth defects, including ocular coloboma. We provide robust spatial-temporal staging and unique anatomical detail of optic fissure closure (OFC) in the embryoni...

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Bibliographic Details
Main Authors: Holly Hardy, James GD Prendergast, Aara Patel, Sunit Dutta, Violeta Trejo-Reveles, Hannah Kroeger, Andrea R Yung, Lisa V Goodrich, Brian Brooks, Jane C Sowden, Joe Rainger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
optic fissure closure
epithelial fusion
netrin
coloboma
cleft palate
CHARGE syndrome
Online Access:https://elifesciences.org/articles/43877

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