AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B
The diabetes drug Metformin decreases hepatic glucose production and activates AMP-activated protein kinase (AMPK). Here the authors provide evidence that AMPK activation antagonizes glucagon signalling by activating PDE4B, lowering cAMP levels and decreasing PKA activation.
Bibliographic Details
| Main Authors: |
M. Johanns,
Y.-C. Lai,
M.-F. Hsu,
R. Jacobs,
D. Vertommen,
J. Van Sande,
J. E. Dumont,
A. Woods,
D. Carling,
L. Hue,
B. Viollet,
M Foretz,
M H Rider |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2016-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms10856
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