AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B
The diabetes drug Metformin decreases hepatic glucose production and activates AMP-activated protein kinase (AMPK). Here the authors provide evidence that AMPK activation antagonizes glucagon signalling by activating PDE4B, lowering cAMP levels and decreasing PKA activation.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10856 |
| _version_ | 1819202410898259968 |
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| author | M. Johanns Y.-C. Lai M.-F. Hsu R. Jacobs D. Vertommen J. Van Sande J. E. Dumont A. Woods D. Carling L. Hue B. Viollet M Foretz M H Rider |
| author_facet | M. Johanns Y.-C. Lai M.-F. Hsu R. Jacobs D. Vertommen J. Van Sande J. E. Dumont A. Woods D. Carling L. Hue B. Viollet M Foretz M H Rider |
| author_sort | M. Johanns |
| collection | DOAJ |
| description | The diabetes drug Metformin decreases hepatic glucose production and activates AMP-activated protein kinase (AMPK). Here the authors provide evidence that AMPK activation antagonizes glucagon signalling by activating PDE4B, lowering cAMP levels and decreasing PKA activation. |
| first_indexed | 2024-12-23T04:03:35Z |
| format | Article |
| id | doaj.art-954bee2fc4df4777831074056e3cfc45 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T04:03:35Z |
| publishDate | 2016-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-954bee2fc4df4777831074056e3cfc452022-12-21T18:00:40ZengNature PortfolioNature Communications2041-17232016-03-017111210.1038/ncomms10856AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4BM. Johanns0Y.-C. Lai1M.-F. Hsu2R. Jacobs3D. Vertommen4J. Van Sande5J. E. Dumont6A. Woods7D. Carling8L. Hue9B. Viollet10M Foretz11M H Rider12Université catholique de Louvain and de Duve InstituteUniversité catholique de Louvain and de Duve InstituteUniversité catholique de Louvain and de Duve InstituteUniversité catholique de Louvain and de Duve InstituteUniversité catholique de Louvain and de Duve InstituteFaculté de Médecine, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Université Libre de Bruxelles (ULB)Faculté de Médecine, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Université Libre de Bruxelles (ULB)Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith HospitalCellular Stress Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith HospitalUniversité catholique de Louvain and de Duve InstituteINSERM U1016, Institut CochinINSERM U1016, Institut CochinUniversité catholique de Louvain and de Duve InstituteThe diabetes drug Metformin decreases hepatic glucose production and activates AMP-activated protein kinase (AMPK). Here the authors provide evidence that AMPK activation antagonizes glucagon signalling by activating PDE4B, lowering cAMP levels and decreasing PKA activation.https://doi.org/10.1038/ncomms10856 |
| spellingShingle | M. Johanns Y.-C. Lai M.-F. Hsu R. Jacobs D. Vertommen J. Van Sande J. E. Dumont A. Woods D. Carling L. Hue B. Viollet M Foretz M H Rider AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B Nature Communications |
| title | AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B |
| title_full | AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B |
| title_fullStr | AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B |
| title_full_unstemmed | AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B |
| title_short | AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B |
| title_sort | ampk antagonizes hepatic glucagon stimulated cyclic amp signalling via phosphorylation induced activation of cyclic nucleotide phosphodiesterase 4b |
| url | https://doi.org/10.1038/ncomms10856 |
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