Predictive factors of disease-free survival after complete pathological response to neoadjuvant radiotherapy for rectal adenocarcinoma: retrospective case series
Abstract Background Many data suggest that patients with low rectal adenocarcinoma who achieved ypT0N0 status have improved survival and disease-free survival (DFS) compared to all other stages however only few data are available regarding the specific prognosis factors of this subgroup. This study...
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BMC
2019-10-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-019-6239-3 |
| _version_ | 1818504088661262336 |
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| author | Amine Souadka Mohammed Anass Majbar Amine Benkabbou Badr Serji Tarik Souiki Sidi Mohammed Bouchentouf Mourad Abid Basma El Khannousi Tijani El Harroudi Hadj Omar El Malki Mohammed Raiss Lahsen Ifrine Khalid Mazaz Aziz Zentar Raouf Mohsine Abdelilah Souadka Abdelkader Belkouchi Mohammed Ahallat Abdelmalek Hrora on behalf of the Moroccan Society of Surgery |
| author_facet | Amine Souadka Mohammed Anass Majbar Amine Benkabbou Badr Serji Tarik Souiki Sidi Mohammed Bouchentouf Mourad Abid Basma El Khannousi Tijani El Harroudi Hadj Omar El Malki Mohammed Raiss Lahsen Ifrine Khalid Mazaz Aziz Zentar Raouf Mohsine Abdelilah Souadka Abdelkader Belkouchi Mohammed Ahallat Abdelmalek Hrora on behalf of the Moroccan Society of Surgery |
| author_sort | Amine Souadka |
| collection | DOAJ |
| description | Abstract Background Many data suggest that patients with low rectal adenocarcinoma who achieved ypT0N0 status have improved survival and disease-free survival (DFS) compared to all other stages however only few data are available regarding the specific prognosis factors of this subgroup. This study aimed to evaluate predictive factors for disease free survival after complete pathological response (CPR) in cases of low rectal adenocarcinoma. Materials and methods From January 2005 to December 2013, all patients with low rectal adenocarcinoma who underwent neoadjuvant chemoradiotherapy followed by total mesorectal excision and achieved CPR were included at 7 Moroccan and 1 Algerian centres. Predictive factors for disease-free survival were analysed by uni and multivariate analysis. Results Eigthy-four (12.1%) patients achieved a CPR (ypT0N0). Multivariate analysis revealed that both poorly differentiated tumors (OR, 9.23; 95 CI 1.35–62.82; P = 0.023) and the occurrence of perineal sepsis (OR, 13.51; 95 CI 1.96–93.12; P = 0.008) were independently associated with impaired DFS. Conclusions Patients with low rectal cancer who exhibited a CPR after neoadjuvant therapy have good prognoses; however, the occurrence of perineal sepsis and/or poor initial differentiation may be associated with impaired DFS in these patients. Trial registration: The study was retrospectively registered the 28th July 2018 in ClinicalTrials.gov register with the reference NCT03601689. |
| first_indexed | 2024-12-10T21:32:23Z |
| format | Article |
| id | doaj.art-954e26fa892a4b7982fc4c263931a4b5 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-10T21:32:23Z |
| publishDate | 2019-10-01 |
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| series | BMC Cancer |
| spelling | doaj.art-954e26fa892a4b7982fc4c263931a4b52022-12-22T01:32:45ZengBMCBMC Cancer1471-24072019-10-011911710.1186/s12885-019-6239-3Predictive factors of disease-free survival after complete pathological response to neoadjuvant radiotherapy for rectal adenocarcinoma: retrospective case seriesAmine Souadka0Mohammed Anass Majbar1Amine Benkabbou2Badr Serji3Tarik Souiki4Sidi Mohammed Bouchentouf5Mourad Abid6Basma El Khannousi7Tijani El Harroudi8Hadj Omar El Malki9Mohammed Raiss10Lahsen Ifrine11Khalid Mazaz12Aziz Zentar13Raouf Mohsine14Abdelilah Souadka15Abdelkader Belkouchi16Mohammed AhallatAbdelmalek Hrora17on behalf of the Moroccan Society of SurgerySurgical Oncology Department, National Institute of Oncology, Mohammed V University Medical SchoolSurgical Oncology Department, National Institute of Oncology, Mohammed V University Medical SchoolSurgical Oncology Department, National Institute of Oncology, Mohammed V University Medical SchoolSurgical Oncology, Hospital El Farabi, Mohammed Ist UniversitySurgery Department, Sidi Mohammed Ben Abdellah UniversitySurgery Department, Military HospitalBatna Anticancer Center AlgerAnatomopathology Department, National Institute of OncologySurgical Oncology, Hospital El Farabi, Mohammed Ist UniversitySurgical Department “A”, Ibn Sina HospitalAnatomopathology Department, National Institute of OncologySurgical Department “A”, Ibn Sina HospitalSurgery Department, Sidi Mohammed Ben Abdellah UniversitySurgery Department, Military HospitalSurgical Oncology Department, National Institute of Oncology, Mohammed V University Medical SchoolPrivate surgical oncology centerSurgical Department “A”, Ibn Sina HospitalSurgical Oncology Department, National Institute of Oncology, Mohammed V University Medical SchoolAbstract Background Many data suggest that patients with low rectal adenocarcinoma who achieved ypT0N0 status have improved survival and disease-free survival (DFS) compared to all other stages however only few data are available regarding the specific prognosis factors of this subgroup. This study aimed to evaluate predictive factors for disease free survival after complete pathological response (CPR) in cases of low rectal adenocarcinoma. Materials and methods From January 2005 to December 2013, all patients with low rectal adenocarcinoma who underwent neoadjuvant chemoradiotherapy followed by total mesorectal excision and achieved CPR were included at 7 Moroccan and 1 Algerian centres. Predictive factors for disease-free survival were analysed by uni and multivariate analysis. Results Eigthy-four (12.1%) patients achieved a CPR (ypT0N0). Multivariate analysis revealed that both poorly differentiated tumors (OR, 9.23; 95 CI 1.35–62.82; P = 0.023) and the occurrence of perineal sepsis (OR, 13.51; 95 CI 1.96–93.12; P = 0.008) were independently associated with impaired DFS. Conclusions Patients with low rectal cancer who exhibited a CPR after neoadjuvant therapy have good prognoses; however, the occurrence of perineal sepsis and/or poor initial differentiation may be associated with impaired DFS in these patients. Trial registration: The study was retrospectively registered the 28th July 2018 in ClinicalTrials.gov register with the reference NCT03601689.http://link.springer.com/article/10.1186/s12885-019-6239-3Rectal neoplasmNeoadjuvant treatmentComplete pathological responseDisease-free survivalPredictive factors |
| spellingShingle | Amine Souadka Mohammed Anass Majbar Amine Benkabbou Badr Serji Tarik Souiki Sidi Mohammed Bouchentouf Mourad Abid Basma El Khannousi Tijani El Harroudi Hadj Omar El Malki Mohammed Raiss Lahsen Ifrine Khalid Mazaz Aziz Zentar Raouf Mohsine Abdelilah Souadka Abdelkader Belkouchi Mohammed Ahallat Abdelmalek Hrora on behalf of the Moroccan Society of Surgery Predictive factors of disease-free survival after complete pathological response to neoadjuvant radiotherapy for rectal adenocarcinoma: retrospective case series BMC Cancer Rectal neoplasm Neoadjuvant treatment Complete pathological response Disease-free survival Predictive factors |
| title | Predictive factors of disease-free survival after complete pathological response to neoadjuvant radiotherapy for rectal adenocarcinoma: retrospective case series |
| title_full | Predictive factors of disease-free survival after complete pathological response to neoadjuvant radiotherapy for rectal adenocarcinoma: retrospective case series |
| title_fullStr | Predictive factors of disease-free survival after complete pathological response to neoadjuvant radiotherapy for rectal adenocarcinoma: retrospective case series |
| title_full_unstemmed | Predictive factors of disease-free survival after complete pathological response to neoadjuvant radiotherapy for rectal adenocarcinoma: retrospective case series |
| title_short | Predictive factors of disease-free survival after complete pathological response to neoadjuvant radiotherapy for rectal adenocarcinoma: retrospective case series |
| title_sort | predictive factors of disease free survival after complete pathological response to neoadjuvant radiotherapy for rectal adenocarcinoma retrospective case series |
| topic | Rectal neoplasm Neoadjuvant treatment Complete pathological response Disease-free survival Predictive factors |
| url | http://link.springer.com/article/10.1186/s12885-019-6239-3 |
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