Biomarkers of Drug Resistance in Temporal Lobe Epilepsy in Adults
Temporal lobe epilepsy (TLE) is the most common type of focal epilepsy in adults. Experimental and clinical data indicate that neuroinflammation and neurodegeneration accompanying epileptogenesis make a significant contribution to the chronicity of epilepsy and the development of drug resistance in...
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MDPI AG
2023-01-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/1/83 |
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| author | Yulia S. Panina Elena E. Timechko Anna A. Usoltseva Kristina D. Yakovleva Elena A. Kantimirova Diana V. Dmitrenko |
| author_facet | Yulia S. Panina Elena E. Timechko Anna A. Usoltseva Kristina D. Yakovleva Elena A. Kantimirova Diana V. Dmitrenko |
| author_sort | Yulia S. Panina |
| collection | DOAJ |
| description | Temporal lobe epilepsy (TLE) is the most common type of focal epilepsy in adults. Experimental and clinical data indicate that neuroinflammation and neurodegeneration accompanying epileptogenesis make a significant contribution to the chronicity of epilepsy and the development of drug resistance in TLE cases. Changes in plasma and serum concentrations of proteins associated with neuroinflammation and neurodegeneration can be predictive biomarkers of the course of the disease. This study used an enzyme-linked immunosorbent assay of the following plasma proteins: brain-derived neurotrophic factor (<i>BDNF</i>), tumor necrosis factor alpha (<i>TNFa</i>), and high-mobility group protein B1 (<i>HMGB1</i>) in patients with mesial TLE to search for biomarkers of the disease. The objective of the study was to examine biomarkers of the neuroinflammation and neurodegeneration of plasma: <i>BDNF</i>, <i>TNFa</i>, and <i>HMGB1</i>. The aim of the study was to identify changes in the concentration of circulating pro-inflammatory and neurotrophic factors that are prognostically significant for the development of drug resistance and the course of TLE. A decrease in the concentration of <i>BDNF</i>, <i>TNFa</i>, and <i>HMGB1</i> was registered in the group of patients with TLE compared with the control group. A significant decrease in the concentration of HMGB1 in patients with drug-resistant TLE was observed. Aberrations in plasma concentrations of <i>BDNF</i>, <i>TNFa</i>, and <i>HMGB1</i> in patients with TLE compared with the controls have been confirmed by earlier studies. A decrease in the expression of the three biomarkers may be the result of neurodegenerative processes caused by the long course of the disease. The results of the study may indicate the acceptability of using <i>HMGB1</i> and <i>TNFa</i> as prognostic biological markers to indicate the severity of the disease course and the risk of developing drug resistance. |
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| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T11:42:41Z |
| publishDate | 2023-01-01 |
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| spelling | doaj.art-955064b050fa4d17a8ba1c9769a32c6a2023-11-30T23:28:46ZengMDPI AGMetabolites2218-19892023-01-011318310.3390/metabo13010083Biomarkers of Drug Resistance in Temporal Lobe Epilepsy in AdultsYulia S. Panina0Elena E. Timechko1Anna A. Usoltseva2Kristina D. Yakovleva3Elena A. Kantimirova4Diana V. Dmitrenko5Department of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, RussiaDepartment of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, RussiaDepartment of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, RussiaDepartment of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, RussiaDepartment of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, RussiaDepartment of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, RussiaTemporal lobe epilepsy (TLE) is the most common type of focal epilepsy in adults. Experimental and clinical data indicate that neuroinflammation and neurodegeneration accompanying epileptogenesis make a significant contribution to the chronicity of epilepsy and the development of drug resistance in TLE cases. Changes in plasma and serum concentrations of proteins associated with neuroinflammation and neurodegeneration can be predictive biomarkers of the course of the disease. This study used an enzyme-linked immunosorbent assay of the following plasma proteins: brain-derived neurotrophic factor (<i>BDNF</i>), tumor necrosis factor alpha (<i>TNFa</i>), and high-mobility group protein B1 (<i>HMGB1</i>) in patients with mesial TLE to search for biomarkers of the disease. The objective of the study was to examine biomarkers of the neuroinflammation and neurodegeneration of plasma: <i>BDNF</i>, <i>TNFa</i>, and <i>HMGB1</i>. The aim of the study was to identify changes in the concentration of circulating pro-inflammatory and neurotrophic factors that are prognostically significant for the development of drug resistance and the course of TLE. A decrease in the concentration of <i>BDNF</i>, <i>TNFa</i>, and <i>HMGB1</i> was registered in the group of patients with TLE compared with the control group. A significant decrease in the concentration of HMGB1 in patients with drug-resistant TLE was observed. Aberrations in plasma concentrations of <i>BDNF</i>, <i>TNFa</i>, and <i>HMGB1</i> in patients with TLE compared with the controls have been confirmed by earlier studies. A decrease in the expression of the three biomarkers may be the result of neurodegenerative processes caused by the long course of the disease. The results of the study may indicate the acceptability of using <i>HMGB1</i> and <i>TNFa</i> as prognostic biological markers to indicate the severity of the disease course and the risk of developing drug resistance.https://www.mdpi.com/2218-1989/13/1/83temporal lobe epilepsybiomarkersdrug resistanceneuroinflammationneurodegeneration |
| spellingShingle | Yulia S. Panina Elena E. Timechko Anna A. Usoltseva Kristina D. Yakovleva Elena A. Kantimirova Diana V. Dmitrenko Biomarkers of Drug Resistance in Temporal Lobe Epilepsy in Adults Metabolites temporal lobe epilepsy biomarkers drug resistance neuroinflammation neurodegeneration |
| title | Biomarkers of Drug Resistance in Temporal Lobe Epilepsy in Adults |
| title_full | Biomarkers of Drug Resistance in Temporal Lobe Epilepsy in Adults |
| title_fullStr | Biomarkers of Drug Resistance in Temporal Lobe Epilepsy in Adults |
| title_full_unstemmed | Biomarkers of Drug Resistance in Temporal Lobe Epilepsy in Adults |
| title_short | Biomarkers of Drug Resistance in Temporal Lobe Epilepsy in Adults |
| title_sort | biomarkers of drug resistance in temporal lobe epilepsy in adults |
| topic | temporal lobe epilepsy biomarkers drug resistance neuroinflammation neurodegeneration |
| url | https://www.mdpi.com/2218-1989/13/1/83 |
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