High Glucose Reduces the Paracellular Permeability of the Submandibular Gland Epithelium via the MiR-22-3p/Sp1/Claudin Pathway

High Glucose Reduces the Paracellular Permeability of the Submandibular Gland Epithelium via the MiR-22-3p/Sp1/Claudin Pathway

Tight junctions (TJs) play an important role in water, ion, and solute transport through the paracellular pathway of epithelial cells; however, their role in diabetes-induced salivary gland dysfunction remains unknown. Here, we found that the TJ proteins claudin-1 and claudin-3 were significantly in...

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Bibliographic Details
Main Authors: Yan Huang, Hui-Min Liu, Qian-Ying Mao, Xin Cong, Yan Zhang, Sang-Woo Lee, Kyungpyo Park, Li-Ling Wu, Ruo-Lan Xiang, Guang-Yan Yu
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
diabetes
submandibular gland
microRNA-22-3p
tight junction
specificity protein-1
Online Access:https://www.mdpi.com/2073-4409/10/11/3230

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