Histopathological Findings and Metagenomic Analysis of Esophageal Papillary Proliferation Identified in Laying Broiler Breeders
White or pale-yellow nodules 2–7 mm in length were observed in the esophageal lumen in a number of laying broiler breeders with reduced laying rates. Metaplasia of the mucosal epithelial layer and mucous gland, as well as lymphocyte infiltration under the esophageal mucous gland and epithelial cell...
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MDPI AG
2022-06-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/9/7/332 |
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| author | Si-Hyeon Kim Hye-Soon Song Chung-Hyun Kim Yong-Kuk Kwon Choi-Kyu Park Hye-Ryoung Kim |
| author_facet | Si-Hyeon Kim Hye-Soon Song Chung-Hyun Kim Yong-Kuk Kwon Choi-Kyu Park Hye-Ryoung Kim |
| author_sort | Si-Hyeon Kim |
| collection | DOAJ |
| description | White or pale-yellow nodules 2–7 mm in length were observed in the esophageal lumen in a number of laying broiler breeders with reduced laying rates. Metaplasia of the mucosal epithelial layer and mucous gland, as well as lymphocyte infiltration under the esophageal mucous gland and epithelial cell layer, were observed, which we found were caused by vitamin A deficiency. In one chicken, however, the stratified squamous epithelial cells of the esophagus were completely replaced by increased numbers of ducts/ductules, lymphocytes, and connective tissue, resulting in a papillary morphology. The ducts were surrounded by a fibrous stroma. Multiple hyperplasia of the esophageal gland was also observed and the esophageal glands were lined by a single layer of columnar cells, and a large number of lymphocytes were infiltrated into the submucosal layer. Based on the gross findings, this papillary proliferation was considered papilloma, but histopathologically, a mass composed of squamous epithelium was not observed. Therefore, the papillary lesion appeared as adenoma with squamous metaplasia of the esophageal gland and ectasia, or mucosal epithelial papillary hyperplasia, associated with chronic esophagitis. A metagenomic analysis of the esophagus samples from this chicken was performed to determine the infectious etiology. No viral cause was identified; however, a contributing role of <i>Bradyrhizobium</i> sp. could not be excluded. In this study, we report the first histopathological examination of a rare case of esophageal papillary proliferation in a chicken and highlight the importance of histopathological results for a definitive diagnosis of such cases. |
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| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-09T05:42:19Z |
| publishDate | 2022-06-01 |
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| series | Veterinary Sciences |
| spelling | doaj.art-955259025209403fa0998d8c2afc6b492023-12-03T12:23:50ZengMDPI AGVeterinary Sciences2306-73812022-06-019733210.3390/vetsci9070332Histopathological Findings and Metagenomic Analysis of Esophageal Papillary Proliferation Identified in Laying Broiler BreedersSi-Hyeon Kim0Hye-Soon Song1Chung-Hyun Kim2Yong-Kuk Kwon3Choi-Kyu Park4Hye-Ryoung Kim5Avian Disease Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, KoreaAvian Disease Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, KoreaAvian Disease Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, KoreaAvian Disease Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, KoreaCollege of Veterinary Medicine & Animal Disease Intervention Center, Kyungpook National University, Daegu 41566, KoreaAvian Disease Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, KoreaWhite or pale-yellow nodules 2–7 mm in length were observed in the esophageal lumen in a number of laying broiler breeders with reduced laying rates. Metaplasia of the mucosal epithelial layer and mucous gland, as well as lymphocyte infiltration under the esophageal mucous gland and epithelial cell layer, were observed, which we found were caused by vitamin A deficiency. In one chicken, however, the stratified squamous epithelial cells of the esophagus were completely replaced by increased numbers of ducts/ductules, lymphocytes, and connective tissue, resulting in a papillary morphology. The ducts were surrounded by a fibrous stroma. Multiple hyperplasia of the esophageal gland was also observed and the esophageal glands were lined by a single layer of columnar cells, and a large number of lymphocytes were infiltrated into the submucosal layer. Based on the gross findings, this papillary proliferation was considered papilloma, but histopathologically, a mass composed of squamous epithelium was not observed. Therefore, the papillary lesion appeared as adenoma with squamous metaplasia of the esophageal gland and ectasia, or mucosal epithelial papillary hyperplasia, associated with chronic esophagitis. A metagenomic analysis of the esophagus samples from this chicken was performed to determine the infectious etiology. No viral cause was identified; however, a contributing role of <i>Bradyrhizobium</i> sp. could not be excluded. In this study, we report the first histopathological examination of a rare case of esophageal papillary proliferation in a chicken and highlight the importance of histopathological results for a definitive diagnosis of such cases.https://www.mdpi.com/2306-7381/9/7/332esophageal papillary proliferationvitamin A deficiencymetagenomics |
| spellingShingle | Si-Hyeon Kim Hye-Soon Song Chung-Hyun Kim Yong-Kuk Kwon Choi-Kyu Park Hye-Ryoung Kim Histopathological Findings and Metagenomic Analysis of Esophageal Papillary Proliferation Identified in Laying Broiler Breeders Veterinary Sciences esophageal papillary proliferation vitamin A deficiency metagenomics |
| title | Histopathological Findings and Metagenomic Analysis of Esophageal Papillary Proliferation Identified in Laying Broiler Breeders |
| title_full | Histopathological Findings and Metagenomic Analysis of Esophageal Papillary Proliferation Identified in Laying Broiler Breeders |
| title_fullStr | Histopathological Findings and Metagenomic Analysis of Esophageal Papillary Proliferation Identified in Laying Broiler Breeders |
| title_full_unstemmed | Histopathological Findings and Metagenomic Analysis of Esophageal Papillary Proliferation Identified in Laying Broiler Breeders |
| title_short | Histopathological Findings and Metagenomic Analysis of Esophageal Papillary Proliferation Identified in Laying Broiler Breeders |
| title_sort | histopathological findings and metagenomic analysis of esophageal papillary proliferation identified in laying broiler breeders |
| topic | esophageal papillary proliferation vitamin A deficiency metagenomics |
| url | https://www.mdpi.com/2306-7381/9/7/332 |
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