Functions of N6-methyladenosine and its role in cancer
Abstract N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which is the most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests that m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-12-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-019-1109-9 |
| _version_ | 1818928968833695744 |
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| author | Liuer He Huiyu Li Anqi Wu Yulong Peng Guang Shu Gang Yin |
| author_facet | Liuer He Huiyu Li Anqi Wu Yulong Peng Guang Shu Gang Yin |
| author_sort | Liuer He |
| collection | DOAJ |
| description | Abstract N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which is the most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests that m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differentiation, invasion and apoptosis. M6A is installed by m6A methyltransferases, removed by m6A demethylases and recognized by reader proteins, which regulate of RNA metabolism including translation, splicing, export, degradation and microRNA processing. Alteration of m6A levels participates in cancer pathogenesis and development via regulating expression of tumor-related genes like BRD4, MYC, SOCS2 and EGFR. In this review, we elaborate on recent advances in research of m6A enzymes. We also highlight the underlying mechanism of m6A in cancer pathogenesis and progression. Finally, we review corresponding potential targets in cancer therapy. |
| first_indexed | 2024-12-20T03:37:20Z |
| format | Article |
| id | doaj.art-9552dd5f313a45ddacdda62c1c50dc63 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-20T03:37:20Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-9552dd5f313a45ddacdda62c1c50dc632022-12-21T19:54:50ZengBMCMolecular Cancer1476-45982019-12-0118111510.1186/s12943-019-1109-9Functions of N6-methyladenosine and its role in cancerLiuer He0Huiyu Li1Anqi Wu2Yulong Peng3Guang Shu4Gang Yin5Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South UniversityDepartment of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South UniversityDepartment of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South UniversityDepartment of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South UniversitySchool of Basic Medical Sciences, Central South UniversityDepartment of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South UniversityAbstract N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which is the most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests that m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differentiation, invasion and apoptosis. M6A is installed by m6A methyltransferases, removed by m6A demethylases and recognized by reader proteins, which regulate of RNA metabolism including translation, splicing, export, degradation and microRNA processing. Alteration of m6A levels participates in cancer pathogenesis and development via regulating expression of tumor-related genes like BRD4, MYC, SOCS2 and EGFR. In this review, we elaborate on recent advances in research of m6A enzymes. We also highlight the underlying mechanism of m6A in cancer pathogenesis and progression. Finally, we review corresponding potential targets in cancer therapy.https://doi.org/10.1186/s12943-019-1109-9N6-methyladenosinewritereraserreadercancer |
| spellingShingle | Liuer He Huiyu Li Anqi Wu Yulong Peng Guang Shu Gang Yin Functions of N6-methyladenosine and its role in cancer Molecular Cancer N6-methyladenosine writer eraser reader cancer |
| title | Functions of N6-methyladenosine and its role in cancer |
| title_full | Functions of N6-methyladenosine and its role in cancer |
| title_fullStr | Functions of N6-methyladenosine and its role in cancer |
| title_full_unstemmed | Functions of N6-methyladenosine and its role in cancer |
| title_short | Functions of N6-methyladenosine and its role in cancer |
| title_sort | functions of n6 methyladenosine and its role in cancer |
| topic | N6-methyladenosine writer eraser reader cancer |
| url | https://doi.org/10.1186/s12943-019-1109-9 |
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