Progression and trajectory network of age-related functional impairments and their combined associations with mortality
Summary: Age-related functional impairments (ARFIs) contribute to the loss of independence in older adults, but their progressions, interrelations, and combined relations with mortality are largely unknown. We conducted a prospective study among 17,914 participants in the Health and Retirement Study...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223024458 |
| _version_ | 1797388755056721920 |
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| author | Hui Chen Binghan Wang Rongxia Lv Tianjing Zhou Jie Shen Huan Song Xiaolin Xu Yuan Ma Changzheng Yuan |
| author_facet | Hui Chen Binghan Wang Rongxia Lv Tianjing Zhou Jie Shen Huan Song Xiaolin Xu Yuan Ma Changzheng Yuan |
| author_sort | Hui Chen |
| collection | DOAJ |
| description | Summary: Age-related functional impairments (ARFIs) contribute to the loss of independence in older adults, but their progressions, interrelations, and combined relations with mortality are largely unknown. We conducted a prospective study among 17,914 participants in the Health and Retirement Study (2000–2020). The incidence rates of visual impairment, hearing impairment, physical frailty, and cognitive impairment increased exponentially with age, while those of restless sleep and depression increased relatively slowly. These ARFIs were associated with each other in temporal sequence and constituted a hazard network. We observed a dose-response relationship between the number of ARFIs and mortality risk, and the dyads involving physical frailty demonstrated the strongest associations with mortality. Our findings may assist in the identification of individuals at higher mortality risk and highlight the potential for future investigations to explore the impact of multiple ARFIs in aging. |
| first_indexed | 2024-03-08T22:45:24Z |
| format | Article |
| id | doaj.art-95559d783bbc4ecda85eb7c2ad287ccd |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-08T22:45:24Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-95559d783bbc4ecda85eb7c2ad287ccd2023-12-17T06:40:30ZengElsevieriScience2589-00422023-12-012612108368Progression and trajectory network of age-related functional impairments and their combined associations with mortalityHui Chen0Binghan Wang1Rongxia Lv2Tianjing Zhou3Jie Shen4Huan Song5Xiaolin Xu6Yuan Ma7Changzheng Yuan8School of Public Health, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaSchool of Public Health, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaSchool of Public Health, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaSchool of Public Health, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaSchool of Public Health, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaWest China Biomedical Big Data Center and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, IcelandSchool of Public Health, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; School of Public Health, Faculty of Medicine, The University of Queensland, Brisbane, QLD, AustraliaDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USASchool of Public Health, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Corresponding authorSummary: Age-related functional impairments (ARFIs) contribute to the loss of independence in older adults, but their progressions, interrelations, and combined relations with mortality are largely unknown. We conducted a prospective study among 17,914 participants in the Health and Retirement Study (2000–2020). The incidence rates of visual impairment, hearing impairment, physical frailty, and cognitive impairment increased exponentially with age, while those of restless sleep and depression increased relatively slowly. These ARFIs were associated with each other in temporal sequence and constituted a hazard network. We observed a dose-response relationship between the number of ARFIs and mortality risk, and the dyads involving physical frailty demonstrated the strongest associations with mortality. Our findings may assist in the identification of individuals at higher mortality risk and highlight the potential for future investigations to explore the impact of multiple ARFIs in aging.http://www.sciencedirect.com/science/article/pii/S2589004223024458health sciencesagebioinformaticsassociation analysis |
| spellingShingle | Hui Chen Binghan Wang Rongxia Lv Tianjing Zhou Jie Shen Huan Song Xiaolin Xu Yuan Ma Changzheng Yuan Progression and trajectory network of age-related functional impairments and their combined associations with mortality iScience health sciences age bioinformatics association analysis |
| title | Progression and trajectory network of age-related functional impairments and their combined associations with mortality |
| title_full | Progression and trajectory network of age-related functional impairments and their combined associations with mortality |
| title_fullStr | Progression and trajectory network of age-related functional impairments and their combined associations with mortality |
| title_full_unstemmed | Progression and trajectory network of age-related functional impairments and their combined associations with mortality |
| title_short | Progression and trajectory network of age-related functional impairments and their combined associations with mortality |
| title_sort | progression and trajectory network of age related functional impairments and their combined associations with mortality |
| topic | health sciences age bioinformatics association analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223024458 |
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