Semi-Mechanistic Model for the Antitumor Response of a Combination Cocktail of Immuno-Modulators in Non-Inflamed (Cold) Tumors

Semi-Mechanistic Model for the Antitumor Response of a Combination Cocktail of Immuno-Modulators in Non-Inflamed (Cold) Tumors

Immune checkpoint inhibitors, administered as single agents, have demonstrated clinical efficacy. However, when treating cold tumors, different combination strategies are needed. This work aims to develop a semi-mechanistic model describing the antitumor efficacy of immunotherapy combinations in col...

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Bibliographic Details
Main Authors: Aymara Sancho-Araiz, Sara Zalba, María J. Garrido, Pedro Berraondo, Brian Topp, Dinesh de Alwis, Zinnia P. Parra-Guillen, Víctor Mangas-Sanjuan, Iñaki F. Trocóniz
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
cold tumors
immuno-oncology
preclinical
drug development
combination of therapeutics
mechanistic modeling
Online Access:https://www.mdpi.com/2072-6694/13/20/5049

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