40 Hz Blue LED Relieves the Gamma Oscillations Changes Caused by Traumatic Brain Injury in Rat
BackgroundPhotobiomodulation (PBM) using low-level light-emitting diodes (LEDs) can be rapidly applied to various neurological disorders safely and non-invasively.Materials and MethodsForty-eight rats were involved in this study. The traumatic brain injury (TBI) model of rat was set up by a controll...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.882991/full |
| _version_ | 1811333641593159680 |
|---|---|
| author | Xiaoyu Yang Xuepei Li Yikai Yuan Tong Sun Jingguo Yang Bo Deng Hang Yu Anliang Gao Junwen Guan |
| author_facet | Xiaoyu Yang Xuepei Li Yikai Yuan Tong Sun Jingguo Yang Bo Deng Hang Yu Anliang Gao Junwen Guan |
| author_sort | Xiaoyu Yang |
| collection | DOAJ |
| description | BackgroundPhotobiomodulation (PBM) using low-level light-emitting diodes (LEDs) can be rapidly applied to various neurological disorders safely and non-invasively.Materials and MethodsForty-eight rats were involved in this study. The traumatic brain injury (TBI) model of rat was set up by a controlled cortical impact (CCI) injury. An 8-channel cortex electrode EEG was fixed to two hemispheres, and gamma oscillations were extracted according to each electrode. A 40 hz blue LED stimulation was set at four points of the frontal and parietal regions for 60 s each, six times per day for 1 week. Modified Neurologic Severity Scores (mNSS) were used to evaluate the level of neurological function.ResultsIn the right-side TBI model, the gamma oscillation decreased in electrodes Fp2, T4, C4, and O2; but significantly increased after 1 week of 40 hz Blue LED intervention. In the left-side TBI model, the gamma oscillation decreased in electrodes Fp1, T3, C3, and O1; and similarly increased after 1 week of 40 hz Blue LED intervention. Both left and right side TBI rats performed significantly better in mNSS after 40 hz Blue LED intervention.ConclusionTBI causes the decrease of gamma oscillations on the injured side of the brain of rats. The 40 hz Blue LED therapy could relieve the gamma oscillation changes caused by TBI and improve the prognosis of TBI. |
| first_indexed | 2024-04-13T16:56:01Z |
| format | Article |
| id | doaj.art-9557442f9f9f4703a9b71b0cb2d5225e |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T16:56:01Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-9557442f9f9f4703a9b71b0cb2d5225e2022-12-22T02:38:48ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-06-011310.3389/fneur.2022.88299188299140 Hz Blue LED Relieves the Gamma Oscillations Changes Caused by Traumatic Brain Injury in RatXiaoyu Yang0Xuepei Li1Yikai Yuan2Tong Sun3Jingguo Yang4Bo Deng5Hang Yu6Anliang Gao7Junwen Guan8Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, ChinaMedical Simulation Center, Chengdu First People's Hospital, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, ChinaCollege of Electronic Engineering (College of Meteorological Observation), Chengdu University of Information Technology, Chengdu, ChinaCollege of Electronic Engineering (College of Meteorological Observation), Chengdu University of Information Technology, Chengdu, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, ChinaBackgroundPhotobiomodulation (PBM) using low-level light-emitting diodes (LEDs) can be rapidly applied to various neurological disorders safely and non-invasively.Materials and MethodsForty-eight rats were involved in this study. The traumatic brain injury (TBI) model of rat was set up by a controlled cortical impact (CCI) injury. An 8-channel cortex electrode EEG was fixed to two hemispheres, and gamma oscillations were extracted according to each electrode. A 40 hz blue LED stimulation was set at four points of the frontal and parietal regions for 60 s each, six times per day for 1 week. Modified Neurologic Severity Scores (mNSS) were used to evaluate the level of neurological function.ResultsIn the right-side TBI model, the gamma oscillation decreased in electrodes Fp2, T4, C4, and O2; but significantly increased after 1 week of 40 hz Blue LED intervention. In the left-side TBI model, the gamma oscillation decreased in electrodes Fp1, T3, C3, and O1; and similarly increased after 1 week of 40 hz Blue LED intervention. Both left and right side TBI rats performed significantly better in mNSS after 40 hz Blue LED intervention.ConclusionTBI causes the decrease of gamma oscillations on the injured side of the brain of rats. The 40 hz Blue LED therapy could relieve the gamma oscillation changes caused by TBI and improve the prognosis of TBI.https://www.frontiersin.org/articles/10.3389/fneur.2022.882991/fulltraumatic brain injurygamma oscillationsLEDratelectroencephalogram |
| spellingShingle | Xiaoyu Yang Xuepei Li Yikai Yuan Tong Sun Jingguo Yang Bo Deng Hang Yu Anliang Gao Junwen Guan 40 Hz Blue LED Relieves the Gamma Oscillations Changes Caused by Traumatic Brain Injury in Rat Frontiers in Neurology traumatic brain injury gamma oscillations LED rat electroencephalogram |
| title | 40 Hz Blue LED Relieves the Gamma Oscillations Changes Caused by Traumatic Brain Injury in Rat |
| title_full | 40 Hz Blue LED Relieves the Gamma Oscillations Changes Caused by Traumatic Brain Injury in Rat |
| title_fullStr | 40 Hz Blue LED Relieves the Gamma Oscillations Changes Caused by Traumatic Brain Injury in Rat |
| title_full_unstemmed | 40 Hz Blue LED Relieves the Gamma Oscillations Changes Caused by Traumatic Brain Injury in Rat |
| title_short | 40 Hz Blue LED Relieves the Gamma Oscillations Changes Caused by Traumatic Brain Injury in Rat |
| title_sort | 40 hz blue led relieves the gamma oscillations changes caused by traumatic brain injury in rat |
| topic | traumatic brain injury gamma oscillations LED rat electroencephalogram |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.882991/full |
| work_keys_str_mv | AT xiaoyuyang 40hzblueledrelievesthegammaoscillationschangescausedbytraumaticbraininjuryinrat AT xuepeili 40hzblueledrelievesthegammaoscillationschangescausedbytraumaticbraininjuryinrat AT yikaiyuan 40hzblueledrelievesthegammaoscillationschangescausedbytraumaticbraininjuryinrat AT tongsun 40hzblueledrelievesthegammaoscillationschangescausedbytraumaticbraininjuryinrat AT jingguoyang 40hzblueledrelievesthegammaoscillationschangescausedbytraumaticbraininjuryinrat AT bodeng 40hzblueledrelievesthegammaoscillationschangescausedbytraumaticbraininjuryinrat AT hangyu 40hzblueledrelievesthegammaoscillationschangescausedbytraumaticbraininjuryinrat AT anlianggao 40hzblueledrelievesthegammaoscillationschangescausedbytraumaticbraininjuryinrat AT junwenguan 40hzblueledrelievesthegammaoscillationschangescausedbytraumaticbraininjuryinrat |