Evaluation of cytotoxicity, loading, and release activity of paclitaxel loaded-porphyrin based metal-organic framework (PCN-600)
Considering the inducement side impacts and precipitation of continual doses in conventional therapeutic treatments, there is an urgent need in the field of drug delivery for novel designs of biocompatible carriers with wide loading dimensions and particularly the ability to control their drug relea...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022039226 |
| _version_ | 1811173423722790912 |
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| author | Khadijeh Hamidian Mahmood Barani Mahboubeh Adeli-Sardou Mina Sarani Saba Daliran Ali Raza Oveisi |
| author_facet | Khadijeh Hamidian Mahmood Barani Mahboubeh Adeli-Sardou Mina Sarani Saba Daliran Ali Raza Oveisi |
| author_sort | Khadijeh Hamidian |
| collection | DOAJ |
| description | Considering the inducement side impacts and precipitation of continual doses in conventional therapeutic treatments, there is an urgent need in the field of drug delivery for novel designs of biocompatible carriers with wide loading dimensions and particularly the ability to control their drug release. In this work, we succeeded in synthesizing an iron-based organic metal framework based on iron-porphyrin (PCN-600) through a solvothermal method to function as a drug delivery system (DDS). According to SEM results, PCN-600 crystals a hexagonal-rod shaped morphology with the length of 300 nm and width of 100–300 nm. As an anticancer drug, Paclitaxel (PTX) was successfully loaded into the porphyrin-based metal-organic framework (PCN-600) via in-situ encapsulation; the loading efficiency was measured to be about 87.3%. In addition, PTX-encapsulated PCN-600 displayed a controlled and sustained release for up to 24 h of release assessment at the physiological microenvironment of pH = 7.4. |
| first_indexed | 2024-04-10T17:46:37Z |
| format | Article |
| id | doaj.art-95584504736047aba5daa8ebb813bab0 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-10T17:46:37Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-95584504736047aba5daa8ebb813bab02023-02-03T04:58:26ZengElsevierHeliyon2405-84402023-01-0191e12634Evaluation of cytotoxicity, loading, and release activity of paclitaxel loaded-porphyrin based metal-organic framework (PCN-600)Khadijeh Hamidian0Mahmood Barani1Mahboubeh Adeli-Sardou2Mina Sarani3Saba Daliran4Ali Raza Oveisi5Department of Pharmaceutics, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, IranMedical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, 76169-13555, Kerman, IranHerbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran; Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, IranZabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran; Corresponding author.,Department of Chemistry, University of Zabol, P.O. Box: 98615-538, Zabol 9861335856, IranDepartment of Chemistry, University of Zabol, P.O. Box: 98615-538, Zabol 9861335856, Iran; Corresponding author.Considering the inducement side impacts and precipitation of continual doses in conventional therapeutic treatments, there is an urgent need in the field of drug delivery for novel designs of biocompatible carriers with wide loading dimensions and particularly the ability to control their drug release. In this work, we succeeded in synthesizing an iron-based organic metal framework based on iron-porphyrin (PCN-600) through a solvothermal method to function as a drug delivery system (DDS). According to SEM results, PCN-600 crystals a hexagonal-rod shaped morphology with the length of 300 nm and width of 100–300 nm. As an anticancer drug, Paclitaxel (PTX) was successfully loaded into the porphyrin-based metal-organic framework (PCN-600) via in-situ encapsulation; the loading efficiency was measured to be about 87.3%. In addition, PTX-encapsulated PCN-600 displayed a controlled and sustained release for up to 24 h of release assessment at the physiological microenvironment of pH = 7.4.http://www.sciencedirect.com/science/article/pii/S2405844022039226PCN-600Drug deliveryPaclitaxelAnticancer drugsMetal-organic frameworks |
| spellingShingle | Khadijeh Hamidian Mahmood Barani Mahboubeh Adeli-Sardou Mina Sarani Saba Daliran Ali Raza Oveisi Evaluation of cytotoxicity, loading, and release activity of paclitaxel loaded-porphyrin based metal-organic framework (PCN-600) Heliyon PCN-600 Drug delivery Paclitaxel Anticancer drugs Metal-organic frameworks |
| title | Evaluation of cytotoxicity, loading, and release activity of paclitaxel loaded-porphyrin based metal-organic framework (PCN-600) |
| title_full | Evaluation of cytotoxicity, loading, and release activity of paclitaxel loaded-porphyrin based metal-organic framework (PCN-600) |
| title_fullStr | Evaluation of cytotoxicity, loading, and release activity of paclitaxel loaded-porphyrin based metal-organic framework (PCN-600) |
| title_full_unstemmed | Evaluation of cytotoxicity, loading, and release activity of paclitaxel loaded-porphyrin based metal-organic framework (PCN-600) |
| title_short | Evaluation of cytotoxicity, loading, and release activity of paclitaxel loaded-porphyrin based metal-organic framework (PCN-600) |
| title_sort | evaluation of cytotoxicity loading and release activity of paclitaxel loaded porphyrin based metal organic framework pcn 600 |
| topic | PCN-600 Drug delivery Paclitaxel Anticancer drugs Metal-organic frameworks |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022039226 |
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