Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading co...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2009-06-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/14/6/2016/ |
| _version_ | 1819139805263429632 |
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| author | Armin Scheffler Melanie N. Laszczyk Holger Trojan Thomas Kopp Sebastian Jäger |
| author_facet | Armin Scheffler Melanie N. Laszczyk Holger Trojan Thomas Kopp Sebastian Jäger |
| author_sort | Armin Scheffler |
| collection | DOAJ |
| description | Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations. |
| first_indexed | 2024-12-22T11:28:30Z |
| format | Article |
| id | doaj.art-95586dee56c04ec88f45539522438f28 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T11:28:30Z |
| publishDate | 2009-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-95586dee56c04ec88f45539522438f282022-12-21T18:27:41ZengMDPI AGMolecules1420-30492009-06-011462016203110.3390/molecules14062016Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant ExtractsArmin SchefflerMelanie N. LaszczykHolger TrojanThomas KoppSebastian JägerPentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.http://www.mdpi.com/1420-3049/14/6/2016/lupaneoleananeursanetriterpene dry extractactive plant extractstriterpene distribution |
| spellingShingle | Armin Scheffler Melanie N. Laszczyk Holger Trojan Thomas Kopp Sebastian Jäger Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts Molecules lupane oleanane ursane triterpene dry extract active plant extracts triterpene distribution |
| title | Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts |
| title_full | Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts |
| title_fullStr | Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts |
| title_full_unstemmed | Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts |
| title_short | Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts |
| title_sort | pentacyclic triterpene distribution in various plants rich sources for a new group of multi potent plant extracts |
| topic | lupane oleanane ursane triterpene dry extract active plant extracts triterpene distribution |
| url | http://www.mdpi.com/1420-3049/14/6/2016/ |
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