Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation
Sleep, torpor, and hibernation are three distinct hypometabolic states. However, they have some similar physiological features, such as decreased core body temperature and slowing heart rate. In addition, the accumulation of adenosine seems to be a common feature before entry into these three states...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1098976/full |
| _version_ | 1811155441976082432 |
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| author | Wei-Xiang Ma Ping-Chuan Yuan Hui Zhang Ling-Xi Kong Michael Lazarus Wei-Min Qu Yi-Qun Wang Zhi-Li Huang |
| author_facet | Wei-Xiang Ma Ping-Chuan Yuan Hui Zhang Ling-Xi Kong Michael Lazarus Wei-Min Qu Yi-Qun Wang Zhi-Li Huang |
| author_sort | Wei-Xiang Ma |
| collection | DOAJ |
| description | Sleep, torpor, and hibernation are three distinct hypometabolic states. However, they have some similar physiological features, such as decreased core body temperature and slowing heart rate. In addition, the accumulation of adenosine seems to be a common feature before entry into these three states, suggesting that adenosine and its receptors, also known as P1 receptors, may mediate the initiation and maintenance of these states. This review, therefore, summarizes the current research on the roles and possible neurobiological mechanisms of adenosine and P1 receptors in sleep, torpor, and hibernation. Understanding these aspects will give us better prospects in sleep disorders, therapeutic hypothermia, and aerospace medicine. |
| first_indexed | 2024-04-10T04:34:04Z |
| format | Article |
| id | doaj.art-955a847746b84ca3bbe77c3c1287fd1e |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-10T04:34:04Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-955a847746b84ca3bbe77c3c1287fd1e2023-03-10T05:09:13ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-03-011410.3389/fphar.2023.10989761098976Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernationWei-Xiang Ma0Ping-Chuan Yuan1Hui Zhang2Ling-Xi Kong3Michael Lazarus4Wei-Min Qu5Yi-Qun Wang6Zhi-Li Huang7State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Department of Pharmacology, School of Basic Medical Sciences, Institutes of Brain Science, Fudan University, Shanghai, ChinaAnhui Provincial Engineering Research Center for Polysaccharide Drugs, Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, ChinaAnhui Provincial Engineering Research Center for Polysaccharide Drugs, Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, ChinaState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Department of Pharmacology, School of Basic Medical Sciences, Institutes of Brain Science, Fudan University, Shanghai, ChinaInternational Institute for Integrative Sleep Medicine (WPI-IIIS) and Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, JapanState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Department of Pharmacology, School of Basic Medical Sciences, Institutes of Brain Science, Fudan University, Shanghai, ChinaState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Department of Pharmacology, School of Basic Medical Sciences, Institutes of Brain Science, Fudan University, Shanghai, ChinaState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Department of Pharmacology, School of Basic Medical Sciences, Institutes of Brain Science, Fudan University, Shanghai, ChinaSleep, torpor, and hibernation are three distinct hypometabolic states. However, they have some similar physiological features, such as decreased core body temperature and slowing heart rate. In addition, the accumulation of adenosine seems to be a common feature before entry into these three states, suggesting that adenosine and its receptors, also known as P1 receptors, may mediate the initiation and maintenance of these states. This review, therefore, summarizes the current research on the roles and possible neurobiological mechanisms of adenosine and P1 receptors in sleep, torpor, and hibernation. Understanding these aspects will give us better prospects in sleep disorders, therapeutic hypothermia, and aerospace medicine.https://www.frontiersin.org/articles/10.3389/fphar.2023.1098976/fulladenosineP1 receptorshibernationsleeptorpor |
| spellingShingle | Wei-Xiang Ma Ping-Chuan Yuan Hui Zhang Ling-Xi Kong Michael Lazarus Wei-Min Qu Yi-Qun Wang Zhi-Li Huang Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation Frontiers in Pharmacology adenosine P1 receptors hibernation sleep torpor |
| title | Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation |
| title_full | Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation |
| title_fullStr | Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation |
| title_full_unstemmed | Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation |
| title_short | Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation |
| title_sort | adenosine and p1 receptors key targets in the regulation of sleep torpor and hibernation |
| topic | adenosine P1 receptors hibernation sleep torpor |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1098976/full |
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