Compromised Anti-inflammatory Action of Neutrophil Extracellular Traps in PAD4-Deficient Mice Contributes to Aggravated Acute Inflammation After Myocardial Infarction

Compromised Anti-inflammatory Action of Neutrophil Extracellular Traps in PAD4-Deficient Mice Contributes to Aggravated Acute Inflammation After Myocardial Infarction

Innate immune responses and rapid recruitment of leukocytes, which regulate inflammation and subsequent healing, play a key role in acute myocardial infarction (MI). Peptidylarginine deiminase 4 (PAD4) is critically involved in chromatin decondensation during the release of Neutrophil Extracellular...

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Bibliographic Details
Main Authors: Kaveh Eghbalzadeh, Leena Georgi, Theresa Louis, Haizhi Zhao, Ugur Keser, Carolyn Weber, Martin Mollenhauer, Andreas Conforti, Thorsten Wahlers, Adnana Paunel-Görgülü
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
neutrophil extracellular traps
inflammation
PAD4
myocardial infarction
macrophages
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02313/full

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