Ameliorative Effect of Quercetin against Abamectin-Induced Hemato-Biochemical Alterations and Hepatorenal Oxidative Damage in Nile Tilapia, <i>Oreochromis niloticus</i>
Abamectin (ABM) is a common agricultural pesticide and veterinary anthelmintic drug. It can discharge from the sites of application to aquatic systems via surface run-off or spray drift, causing harmful effects to aquatic organisms. The present study investigated the protective effect of dietary que...
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MDPI AG
2022-12-01
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| author | Abdallah Tageldein Mansour Heba H. Mahboub Rehab M. Amen Marwa A. El-Beltagy Amany Ramah Abdelfattah M. Abdelfattah Hossam S. El-Beltagi Tarek A. Shalaby Hesham S. Ghazzawy Khaled M. A. Ramadan Adnan H. M. Alhajji Heba S. Hamed |
| author_facet | Abdallah Tageldein Mansour Heba H. Mahboub Rehab M. Amen Marwa A. El-Beltagy Amany Ramah Abdelfattah M. Abdelfattah Hossam S. El-Beltagi Tarek A. Shalaby Hesham S. Ghazzawy Khaled M. A. Ramadan Adnan H. M. Alhajji Heba S. Hamed |
| author_sort | Abdallah Tageldein Mansour |
| collection | DOAJ |
| description | Abamectin (ABM) is a common agricultural pesticide and veterinary anthelmintic drug. It can discharge from the sites of application to aquatic systems via surface run-off or spray drift, causing harmful effects to aquatic organisms. The present study investigated the protective effect of dietary quercetin supplementation on hemato-biochemical parameters and hepato-renal oxidative stress biomarkers in Nile tilapia (<i>Oreochromis niloticus</i>) exposed to a sublethal dose of ABM. Fish were allocated into six equal groups. The first group was kept as a control group. The second and third groups (Q<sub>400</sub>, and Q<sub>800</sub>) were fed diets supplemented with two quercetin levels (400 and 800 mg/kg diet), respectively. The fourth group (ABM) was intoxicated with 20.73 µg/L of ABM. The fifth and sixth groups (ABM + Q<sub>400</sub>, and ABM + Q<sub>800</sub>) were fed diet supplemented with two quercetin levels (400 and 800 mg/kg diet) and simultaneously intoxicated with ABM for 60 days. The results showed that ABM significantly decreased RBCs, hemoglobin content, hematocrit, total protein, albumin levels, and acetylcholinesterase activity activities compared to the control. Meanwhile, ABM significantly increased white blood cells, glucose, total lipids, cholesterol, and alanine and aspartate aminotransferase activities. Liver and kidney levels of lipid peroxidation was significantly increased, while hepato-renal antioxidant biomarkers (reduced glutathione, super oxide dismutase, catalase, and total antioxidant capacity) were significantly decreased upon ABM exposure. On the other hand, quercetin dietary supplementation improved the hemato-biochemical alterations and alleviated oxidative stress induced by ABM exposure. Fish supplemented with quercetin at a level of 800 mg/kg diet showed better alleviating effects against ABM compared to 400 mg/kg diet. Based on these study findings, we suggest that quercetin dietary supplementation (800 mg/kg) offered direct protection against ABM-induced physiological disturbance and oxidative stress in Nile tilapia. |
| first_indexed | 2024-03-09T17:54:22Z |
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| last_indexed | 2024-03-09T17:54:22Z |
| publishDate | 2022-12-01 |
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| spelling | doaj.art-955b06145d1842a49a5060deb2d0d8592023-11-24T10:26:58ZengMDPI AGAnimals2076-26152022-12-011223342910.3390/ani12233429Ameliorative Effect of Quercetin against Abamectin-Induced Hemato-Biochemical Alterations and Hepatorenal Oxidative Damage in Nile Tilapia, <i>Oreochromis niloticus</i>Abdallah Tageldein Mansour0Heba H. Mahboub1Rehab M. Amen2Marwa A. El-Beltagy3Amany Ramah4Abdelfattah M. Abdelfattah5Hossam S. El-Beltagi6Tarek A. Shalaby7Hesham S. Ghazzawy8Khaled M. A. Ramadan9Adnan H. M. Alhajji10Heba S. Hamed11Fish and Animal Production and Aquaculture Department, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, EgyptDepartment of Zoology, Faculty of Science, Mansoura University, Mansoura 35516, EgyptBiochemistry Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, EgyptGraduate School of Medicine and Veterinary Medicine, University of Miyazaki, 1-1 Gakuen Kibanadai-nishi, Miyazaki 889-2192, JapanDepartment of Clinical Pathology, Faculty of Veterinary Medicine, University of Sadat City, Sadat City 32897, EgyptAgricultural Biotechnology Department, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Arid Land Agriculture, College of Agricultural and Food Science, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDate Palm Research Center of Excellence, King Faisal University, Hofuf 31982, Saudi ArabiaCentral Laboratories, Department of Chemistry, King Faisal University, Al-Ahsa 31982, Saudi ArabiaFish and Animal Production and Aquaculture Department, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Zoology, Faculty of Women for Arts, Science & Education, Ain Shams University, Cairo 11757, EgyptAbamectin (ABM) is a common agricultural pesticide and veterinary anthelmintic drug. It can discharge from the sites of application to aquatic systems via surface run-off or spray drift, causing harmful effects to aquatic organisms. The present study investigated the protective effect of dietary quercetin supplementation on hemato-biochemical parameters and hepato-renal oxidative stress biomarkers in Nile tilapia (<i>Oreochromis niloticus</i>) exposed to a sublethal dose of ABM. Fish were allocated into six equal groups. The first group was kept as a control group. The second and third groups (Q<sub>400</sub>, and Q<sub>800</sub>) were fed diets supplemented with two quercetin levels (400 and 800 mg/kg diet), respectively. The fourth group (ABM) was intoxicated with 20.73 µg/L of ABM. The fifth and sixth groups (ABM + Q<sub>400</sub>, and ABM + Q<sub>800</sub>) were fed diet supplemented with two quercetin levels (400 and 800 mg/kg diet) and simultaneously intoxicated with ABM for 60 days. The results showed that ABM significantly decreased RBCs, hemoglobin content, hematocrit, total protein, albumin levels, and acetylcholinesterase activity activities compared to the control. Meanwhile, ABM significantly increased white blood cells, glucose, total lipids, cholesterol, and alanine and aspartate aminotransferase activities. Liver and kidney levels of lipid peroxidation was significantly increased, while hepato-renal antioxidant biomarkers (reduced glutathione, super oxide dismutase, catalase, and total antioxidant capacity) were significantly decreased upon ABM exposure. On the other hand, quercetin dietary supplementation improved the hemato-biochemical alterations and alleviated oxidative stress induced by ABM exposure. Fish supplemented with quercetin at a level of 800 mg/kg diet showed better alleviating effects against ABM compared to 400 mg/kg diet. Based on these study findings, we suggest that quercetin dietary supplementation (800 mg/kg) offered direct protection against ABM-induced physiological disturbance and oxidative stress in Nile tilapia.https://www.mdpi.com/2076-2615/12/23/3429ivermectinhematobiochemicalNile tilapiaorgan’s dysfunctionoxidative stressquercetin |
| spellingShingle | Abdallah Tageldein Mansour Heba H. Mahboub Rehab M. Amen Marwa A. El-Beltagy Amany Ramah Abdelfattah M. Abdelfattah Hossam S. El-Beltagi Tarek A. Shalaby Hesham S. Ghazzawy Khaled M. A. Ramadan Adnan H. M. Alhajji Heba S. Hamed Ameliorative Effect of Quercetin against Abamectin-Induced Hemato-Biochemical Alterations and Hepatorenal Oxidative Damage in Nile Tilapia, <i>Oreochromis niloticus</i> Animals ivermectin hematobiochemical Nile tilapia organ’s dysfunction oxidative stress quercetin |
| title | Ameliorative Effect of Quercetin against Abamectin-Induced Hemato-Biochemical Alterations and Hepatorenal Oxidative Damage in Nile Tilapia, <i>Oreochromis niloticus</i> |
| title_full | Ameliorative Effect of Quercetin against Abamectin-Induced Hemato-Biochemical Alterations and Hepatorenal Oxidative Damage in Nile Tilapia, <i>Oreochromis niloticus</i> |
| title_fullStr | Ameliorative Effect of Quercetin against Abamectin-Induced Hemato-Biochemical Alterations and Hepatorenal Oxidative Damage in Nile Tilapia, <i>Oreochromis niloticus</i> |
| title_full_unstemmed | Ameliorative Effect of Quercetin against Abamectin-Induced Hemato-Biochemical Alterations and Hepatorenal Oxidative Damage in Nile Tilapia, <i>Oreochromis niloticus</i> |
| title_short | Ameliorative Effect of Quercetin against Abamectin-Induced Hemato-Biochemical Alterations and Hepatorenal Oxidative Damage in Nile Tilapia, <i>Oreochromis niloticus</i> |
| title_sort | ameliorative effect of quercetin against abamectin induced hemato biochemical alterations and hepatorenal oxidative damage in nile tilapia i oreochromis niloticus i |
| topic | ivermectin hematobiochemical Nile tilapia organ’s dysfunction oxidative stress quercetin |
| url | https://www.mdpi.com/2076-2615/12/23/3429 |
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