Expression of transketolase-like protein 1 in human tongue carcinoma and its meaning
Objective To investigate the expression of TKTL1 (transketolase-like protein 1) gene and its correlation with clinicopathological characteristics and prognosis of human tongue squamous cell carcinoma.Methods Immunohistochemistry was used to detect the TKTL1 protein levels in 45 human tongue cancer s...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
2016-03-01
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| Series: | 口腔疾病防治 |
| Subjects: | |
| Online Access: | http://manu45.magtech.com.cn/Jwk3_kqjbfz/EN/10.12016/j.issn.2096-1456.2016.03.005 |
| _version_ | 1818822806548250624 |
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| author | YUE Zeng-wen LIU Jin-zhong ZHU Bao-yu CHEN Zheng-guang |
| author_facet | YUE Zeng-wen LIU Jin-zhong ZHU Bao-yu CHEN Zheng-guang |
| author_sort | YUE Zeng-wen |
| collection | DOAJ |
| description | Objective To investigate the expression of TKTL1 (transketolase-like protein 1) gene and its correlation with clinicopathological characteristics and prognosis of human tongue squamous cell carcinoma.Methods Immunohistochemistry was used to detect the TKTL1 protein levels in 45 human tongue cancer specimens and matched normal tissues.Results The positive expression ratio of TKTL1 protein in tongue squamous carcinoma tissues (68.89%) was significantly higher than that in normal tissues (15.56%), and the difference was statistically significant (χ 2=26.235, P<0.01). The high level of TKTL1 was not statistically correlated with age, gender and tumor differentiated degree (P>0.05), however it was associated with TNM staging and lymph node metastasis (P<0.05) notably. Mantel-Cox demonstrated the survival time of patients with high TKTL1 expression was significantly lower than those with low TKTL1 expressions. Conclusion It suggests a high TKTL1 expression may be tightly related to the occurrence, development, progression and prognosis of human tongue squamous cell carcinoma. |
| first_indexed | 2024-12-18T23:29:56Z |
| format | Article |
| id | doaj.art-955b07bec8c84a549be9607254c9e3de |
| institution | Directory Open Access Journal |
| issn | 2096-1456 2096-1456 |
| language | zho |
| last_indexed | 2024-12-18T23:29:56Z |
| publishDate | 2016-03-01 |
| publisher | Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases |
| record_format | Article |
| series | 口腔疾病防治 |
| spelling | doaj.art-955b07bec8c84a549be9607254c9e3de2022-12-21T20:47:42ZzhoEditorial Department of Journal of Prevention and Treatment for Stomatological Diseases口腔疾病防治2096-14562096-14562016-03-0124315015310.12016/j.issn.2096-1456.2016.03.005Expression of transketolase-like protein 1 in human tongue carcinoma and its meaningYUE Zeng-wen0LIU Jin-zhong1ZHU Bao-yu2CHEN Zheng-guang3 the Fourth Affiliated Hospital of Zhengzhou University the Fourth Affiliated Hospital of Zhengzhou University the Fourth Affiliated Hospital of Zhengzhou University the Fourth Affiliated Hospital of Zhengzhou UniversityObjective To investigate the expression of TKTL1 (transketolase-like protein 1) gene and its correlation with clinicopathological characteristics and prognosis of human tongue squamous cell carcinoma.Methods Immunohistochemistry was used to detect the TKTL1 protein levels in 45 human tongue cancer specimens and matched normal tissues.Results The positive expression ratio of TKTL1 protein in tongue squamous carcinoma tissues (68.89%) was significantly higher than that in normal tissues (15.56%), and the difference was statistically significant (χ 2=26.235, P<0.01). The high level of TKTL1 was not statistically correlated with age, gender and tumor differentiated degree (P>0.05), however it was associated with TNM staging and lymph node metastasis (P<0.05) notably. Mantel-Cox demonstrated the survival time of patients with high TKTL1 expression was significantly lower than those with low TKTL1 expressions. Conclusion It suggests a high TKTL1 expression may be tightly related to the occurrence, development, progression and prognosis of human tongue squamous cell carcinoma.http://manu45.magtech.com.cn/Jwk3_kqjbfz/EN/10.12016/j.issn.2096-1456.2016.03.005Transketolase-like protein 1TongueSquamous cell carcinomaClinicopathological characteristicsPrognosis |
| spellingShingle | YUE Zeng-wen LIU Jin-zhong ZHU Bao-yu CHEN Zheng-guang Expression of transketolase-like protein 1 in human tongue carcinoma and its meaning 口腔疾病防治 Transketolase-like protein 1 Tongue Squamous cell carcinoma Clinicopathological characteristics Prognosis |
| title | Expression of transketolase-like protein 1 in human tongue carcinoma and its meaning |
| title_full | Expression of transketolase-like protein 1 in human tongue carcinoma and its meaning |
| title_fullStr | Expression of transketolase-like protein 1 in human tongue carcinoma and its meaning |
| title_full_unstemmed | Expression of transketolase-like protein 1 in human tongue carcinoma and its meaning |
| title_short | Expression of transketolase-like protein 1 in human tongue carcinoma and its meaning |
| title_sort | expression of transketolase like protein 1 in human tongue carcinoma and its meaning |
| topic | Transketolase-like protein 1 Tongue Squamous cell carcinoma Clinicopathological characteristics Prognosis |
| url | http://manu45.magtech.com.cn/Jwk3_kqjbfz/EN/10.12016/j.issn.2096-1456.2016.03.005 |
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