LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade
Dynamic changes in chromatin landscape affect CD8+ T cell phenotype and function in chronic infections and cancer. Here the authors show that targeting the histone demethylase LSD1 increases the persistence of progenitor exhausted CD8+ T cells, improving response to immune checkpoint blockade in pre...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-27179-7 |
| _version_ | 1818461236619116544 |
|---|---|
| author | Yi Liu Brian Debo Mingfeng Li Zhennan Shi Wanqiang Sheng Yang Shi |
| author_facet | Yi Liu Brian Debo Mingfeng Li Zhennan Shi Wanqiang Sheng Yang Shi |
| author_sort | Yi Liu |
| collection | DOAJ |
| description | Dynamic changes in chromatin landscape affect CD8+ T cell phenotype and function in chronic infections and cancer. Here the authors show that targeting the histone demethylase LSD1 increases the persistence of progenitor exhausted CD8+ T cells, improving response to immune checkpoint blockade in preclinical cancer models. |
| first_indexed | 2024-12-14T23:42:56Z |
| format | Article |
| id | doaj.art-955b0af54ffd473f80b420733cf001e9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T23:42:56Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-955b0af54ffd473f80b420733cf001e92022-12-21T22:43:28ZengNature PortfolioNature Communications2041-17232021-11-0112111610.1038/s41467-021-27179-7LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockadeYi Liu0Brian Debo1Mingfeng Li2Zhennan Shi3Wanqiang Sheng4Yang Shi5Division of Newborn Medicine and Epigenetics Program, Boston Children’s Hospital, Harvard Medical SchoolDivision of Newborn Medicine and Epigenetics Program, Boston Children’s Hospital, Harvard Medical SchoolDepartment of Neuroscience and Kavli Institute for Neuroscience, Yale School of MedicineDivision of Newborn Medicine and Epigenetics Program, Boston Children’s Hospital, Harvard Medical SchoolDivision of Newborn Medicine and Epigenetics Program, Boston Children’s Hospital, Harvard Medical SchoolDivision of Newborn Medicine and Epigenetics Program, Boston Children’s Hospital, Harvard Medical SchoolDynamic changes in chromatin landscape affect CD8+ T cell phenotype and function in chronic infections and cancer. Here the authors show that targeting the histone demethylase LSD1 increases the persistence of progenitor exhausted CD8+ T cells, improving response to immune checkpoint blockade in preclinical cancer models.https://doi.org/10.1038/s41467-021-27179-7 |
| spellingShingle | Yi Liu Brian Debo Mingfeng Li Zhennan Shi Wanqiang Sheng Yang Shi LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade Nature Communications |
| title | LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade |
| title_full | LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade |
| title_fullStr | LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade |
| title_full_unstemmed | LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade |
| title_short | LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade |
| title_sort | lsd1 inhibition sustains t cell invigoration with a durable response to pd 1 blockade |
| url | https://doi.org/10.1038/s41467-021-27179-7 |
| work_keys_str_mv | AT yiliu lsd1inhibitionsustainstcellinvigorationwithadurableresponsetopd1blockade AT briandebo lsd1inhibitionsustainstcellinvigorationwithadurableresponsetopd1blockade AT mingfengli lsd1inhibitionsustainstcellinvigorationwithadurableresponsetopd1blockade AT zhennanshi lsd1inhibitionsustainstcellinvigorationwithadurableresponsetopd1blockade AT wanqiangsheng lsd1inhibitionsustainstcellinvigorationwithadurableresponsetopd1blockade AT yangshi lsd1inhibitionsustainstcellinvigorationwithadurableresponsetopd1blockade |