Alterations in Vascular Function Associated With the Use of Combustible and Electronic Cigarettes
Background Electronic cigarettes (e‐cigarettes) have been proposed as a potential harm reduction tool for combustible cigarette smokers. The majority of adult e‐cigarette users continue to smoke combustible cigarettes and are considered dual users. The vascular impact of e‐cigarettes remains incompl...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-05-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.014570 |
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| author | Jessica L. Fetterman Rachel J. Keith Joseph N. Palmisano Kathleen L. McGlasson Robert M. Weisbrod Sana Majid Reena Bastin Mary Margaret Stathos Andrew C. Stokes Rose Marie Robertson Aruni Bhatnagar Naomi M. Hamburg |
| author_facet | Jessica L. Fetterman Rachel J. Keith Joseph N. Palmisano Kathleen L. McGlasson Robert M. Weisbrod Sana Majid Reena Bastin Mary Margaret Stathos Andrew C. Stokes Rose Marie Robertson Aruni Bhatnagar Naomi M. Hamburg |
| author_sort | Jessica L. Fetterman |
| collection | DOAJ |
| description | Background Electronic cigarettes (e‐cigarettes) have been proposed as a potential harm reduction tool for combustible cigarette smokers. The majority of adult e‐cigarette users continue to smoke combustible cigarettes and are considered dual users. The vascular impact of e‐cigarettes remains incompletely defined. Methods and Results We examined the association of e‐cigarette use with measures of vascular function and tonometry, preclinical measures of cardiovascular injury. As part of the CITU (Cardiovascular Injury due to Tobacco Use) study, we performed noninvasive vascular function testing in individuals without known cardiovascular disease or cardiovascular disease risk factors who were nonsmokers (n=94), users of combustible cigarettes (n=285), users of e‐cigarettes (n=36), or dual users (n=52). In unadjusted analyses, measures of arterial stiffness including carotid‐femoral pulse wave velocity, augmentation index, carotid‐radial pulse wave velocity, and central blood pressures differed across the use groups. In multivariable models adjusted for age, sex, race, and study site, combustible cigarette smokers had higher augmentation index compared with nonusers (129.8±1.5 versus 118.8±2.7, P=0.003). The augmentation index was similar between combustible cigarette smokers compared with sole e‐cigarette users (129.8±1.5 versus 126.2±5.9, P=1.0) and dual users (129.8±1.5 versus 134.9±4.0, P=1.0). Endothelial cells from combustible cigarette smokers and sole e‐cigarette users produced less nitric oxide in response to A23187 stimulation compared with nonsmokers, suggestive of impaired endothelial nitric oxide synthase signaling. Conclusions Our findings suggest that e‐cigarette use is not associated with a more favorable vascular profile. Future longitudinal studies are needed to evaluate the long‐term risks of sustained e‐cigarette use. |
| first_indexed | 2024-12-13T12:26:27Z |
| format | Article |
| id | doaj.art-955c65cf450c45618a5af1875734f6c2 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T12:26:27Z |
| publishDate | 2020-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-955c65cf450c45618a5af1875734f6c22022-12-21T23:46:17ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-05-019910.1161/JAHA.119.014570Alterations in Vascular Function Associated With the Use of Combustible and Electronic CigarettesJessica L. Fetterman0Rachel J. Keith1Joseph N. Palmisano2Kathleen L. McGlasson3Robert M. Weisbrod4Sana Majid5Reena Bastin6Mary Margaret Stathos7Andrew C. Stokes8Rose Marie Robertson9Aruni Bhatnagar10Naomi M. Hamburg11Evans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MAUniversity of Louisville School of Medicine Louisville KYEvans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MAEvans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MAEvans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MAEvans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MAEvans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MAEvans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MASchool of Public Health Boston University Boston MAAmerican Heart Association Dallas TXUniversity of Louisville School of Medicine Louisville KYEvans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MABackground Electronic cigarettes (e‐cigarettes) have been proposed as a potential harm reduction tool for combustible cigarette smokers. The majority of adult e‐cigarette users continue to smoke combustible cigarettes and are considered dual users. The vascular impact of e‐cigarettes remains incompletely defined. Methods and Results We examined the association of e‐cigarette use with measures of vascular function and tonometry, preclinical measures of cardiovascular injury. As part of the CITU (Cardiovascular Injury due to Tobacco Use) study, we performed noninvasive vascular function testing in individuals without known cardiovascular disease or cardiovascular disease risk factors who were nonsmokers (n=94), users of combustible cigarettes (n=285), users of e‐cigarettes (n=36), or dual users (n=52). In unadjusted analyses, measures of arterial stiffness including carotid‐femoral pulse wave velocity, augmentation index, carotid‐radial pulse wave velocity, and central blood pressures differed across the use groups. In multivariable models adjusted for age, sex, race, and study site, combustible cigarette smokers had higher augmentation index compared with nonusers (129.8±1.5 versus 118.8±2.7, P=0.003). The augmentation index was similar between combustible cigarette smokers compared with sole e‐cigarette users (129.8±1.5 versus 126.2±5.9, P=1.0) and dual users (129.8±1.5 versus 134.9±4.0, P=1.0). Endothelial cells from combustible cigarette smokers and sole e‐cigarette users produced less nitric oxide in response to A23187 stimulation compared with nonsmokers, suggestive of impaired endothelial nitric oxide synthase signaling. Conclusions Our findings suggest that e‐cigarette use is not associated with a more favorable vascular profile. Future longitudinal studies are needed to evaluate the long‐term risks of sustained e‐cigarette use.https://www.ahajournals.org/doi/10.1161/JAHA.119.014570e‐cigaretteselectronic cigarettessmokingvascular function |
| spellingShingle | Jessica L. Fetterman Rachel J. Keith Joseph N. Palmisano Kathleen L. McGlasson Robert M. Weisbrod Sana Majid Reena Bastin Mary Margaret Stathos Andrew C. Stokes Rose Marie Robertson Aruni Bhatnagar Naomi M. Hamburg Alterations in Vascular Function Associated With the Use of Combustible and Electronic Cigarettes Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease e‐cigarettes electronic cigarettes smoking vascular function |
| title | Alterations in Vascular Function Associated With the Use of Combustible and Electronic Cigarettes |
| title_full | Alterations in Vascular Function Associated With the Use of Combustible and Electronic Cigarettes |
| title_fullStr | Alterations in Vascular Function Associated With the Use of Combustible and Electronic Cigarettes |
| title_full_unstemmed | Alterations in Vascular Function Associated With the Use of Combustible and Electronic Cigarettes |
| title_short | Alterations in Vascular Function Associated With the Use of Combustible and Electronic Cigarettes |
| title_sort | alterations in vascular function associated with the use of combustible and electronic cigarettes |
| topic | e‐cigarettes electronic cigarettes smoking vascular function |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.014570 |
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