The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells
This overview summarizes recent data disclosing the efficacy of the PARP inhibitor PJ34 in exclusive eradication of a variety of human cancer cells without impairing healthy proliferating cells. Its cytotoxic activity in cancer cells is attributed to the insertion of specific un-repairable anomalies...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/6/1628 |
| _version_ | 1797564755383156736 |
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| author | Malka Cohen-Armon |
| author_facet | Malka Cohen-Armon |
| author_sort | Malka Cohen-Armon |
| collection | DOAJ |
| description | This overview summarizes recent data disclosing the efficacy of the PARP inhibitor PJ34 in exclusive eradication of a variety of human cancer cells without impairing healthy proliferating cells. Its cytotoxic activity in cancer cells is attributed to the insertion of specific un-repairable anomalies in the structure of their mitotic spindle, leading to mitotic catastrophe cell death. This mechanism paves the way to a new concept of cancer therapy. |
| first_indexed | 2024-03-10T19:02:23Z |
| format | Article |
| id | doaj.art-955c8395e76e430483e09be157127239 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T19:02:23Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-955c8395e76e430483e09be1571272392023-11-20T04:21:07ZengMDPI AGCancers2072-66942020-06-01126162810.3390/cancers12061628The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer CellsMalka Cohen-Armon0Sackler Faculty of Medicine, and Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, IsraelThis overview summarizes recent data disclosing the efficacy of the PARP inhibitor PJ34 in exclusive eradication of a variety of human cancer cells without impairing healthy proliferating cells. Its cytotoxic activity in cancer cells is attributed to the insertion of specific un-repairable anomalies in the structure of their mitotic spindle, leading to mitotic catastrophe cell death. This mechanism paves the way to a new concept of cancer therapy.https://www.mdpi.com/2072-6694/12/6/1628the PARP inhibitor PJ34distorted mitotic spindlesexclusive eradication of human cancer cells |
| spellingShingle | Malka Cohen-Armon The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells Cancers the PARP inhibitor PJ34 distorted mitotic spindles exclusive eradication of human cancer cells |
| title | The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells |
| title_full | The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells |
| title_fullStr | The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells |
| title_full_unstemmed | The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells |
| title_short | The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells |
| title_sort | modified phenanthridine pj34 unveils an exclusive cell death mechanism in human cancer cells |
| topic | the PARP inhibitor PJ34 distorted mitotic spindles exclusive eradication of human cancer cells |
| url | https://www.mdpi.com/2072-6694/12/6/1628 |
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