The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells
This overview summarizes recent data disclosing the efficacy of the PARP inhibitor PJ34 in exclusive eradication of a variety of human cancer cells without impairing healthy proliferating cells. Its cytotoxic activity in cancer cells is attributed to the insertion of specific un-repairable anomalies...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-06-01
|
Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/12/6/1628 |
_version_ | 1797564755383156736 |
---|---|
author | Malka Cohen-Armon |
author_facet | Malka Cohen-Armon |
author_sort | Malka Cohen-Armon |
collection | DOAJ |
description | This overview summarizes recent data disclosing the efficacy of the PARP inhibitor PJ34 in exclusive eradication of a variety of human cancer cells without impairing healthy proliferating cells. Its cytotoxic activity in cancer cells is attributed to the insertion of specific un-repairable anomalies in the structure of their mitotic spindle, leading to mitotic catastrophe cell death. This mechanism paves the way to a new concept of cancer therapy. |
first_indexed | 2024-03-10T19:02:23Z |
format | Article |
id | doaj.art-955c8395e76e430483e09be157127239 |
institution | Directory Open Access Journal |
issn | 2072-6694 |
language | English |
last_indexed | 2024-03-10T19:02:23Z |
publishDate | 2020-06-01 |
publisher | MDPI AG |
record_format | Article |
series | Cancers |
spelling | doaj.art-955c8395e76e430483e09be1571272392023-11-20T04:21:07ZengMDPI AGCancers2072-66942020-06-01126162810.3390/cancers12061628The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer CellsMalka Cohen-Armon0Sackler Faculty of Medicine, and Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, IsraelThis overview summarizes recent data disclosing the efficacy of the PARP inhibitor PJ34 in exclusive eradication of a variety of human cancer cells without impairing healthy proliferating cells. Its cytotoxic activity in cancer cells is attributed to the insertion of specific un-repairable anomalies in the structure of their mitotic spindle, leading to mitotic catastrophe cell death. This mechanism paves the way to a new concept of cancer therapy.https://www.mdpi.com/2072-6694/12/6/1628the PARP inhibitor PJ34distorted mitotic spindlesexclusive eradication of human cancer cells |
spellingShingle | Malka Cohen-Armon The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells Cancers the PARP inhibitor PJ34 distorted mitotic spindles exclusive eradication of human cancer cells |
title | The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells |
title_full | The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells |
title_fullStr | The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells |
title_full_unstemmed | The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells |
title_short | The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells |
title_sort | modified phenanthridine pj34 unveils an exclusive cell death mechanism in human cancer cells |
topic | the PARP inhibitor PJ34 distorted mitotic spindles exclusive eradication of human cancer cells |
url | https://www.mdpi.com/2072-6694/12/6/1628 |
work_keys_str_mv | AT malkacohenarmon themodifiedphenanthridinepj34unveilsanexclusivecelldeathmechanisminhumancancercells AT malkacohenarmon modifiedphenanthridinepj34unveilsanexclusivecelldeathmechanisminhumancancercells |