| Summary: | Key Clinical Message The prognosis of patients with relapsed or refractory (R/R) BL is poor with limited response to salvage therapy, especially for patients with early relapse (<6 months) or refractory disease. Novel therapies may be promising but need refinement. Abstract The prognosis of patients with relapsed or refractory (R/R) BL is poor with a limited response to salvage therapy, especially for patients with early relapse (<6 months) or refractory disease. We present three cases of patients with R/R BL receiving novel therapies followed by a literature review. Amongst others, the patients received inotuzumab ozogamicin, idelalisib, ibrutinib, and CAR‐T cell therapy, however, with limited response. In literature, response to several novel agents is described; however, most promising results are seen with CAR‐T cell therapy. Concluding from case series, sequential CAR‐T cell therapy, targeting multiple B‐cell antigens, seems most promising.
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