Drug-resistant strains of Mycobacterium tuberculosis: cell envelope profiles and interactions with the host
In the past few decades, drug-resistant (DR) strains of Mycobacterium tuberculosis (M.tb), the causative agent of tuberculosis (TB), have become increasingly prevalent and pose a threat to worldwide public health. These strains range from multi (MDR) to extensively (XDR) drug-resistant, making them...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1274175/full |
| _version_ | 1827766564641832960 |
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| author | Alyssa Schami Alyssa Schami M. Nurul Islam John T. Belisle Jordi B. Torrelles Jordi B. Torrelles |
| author_facet | Alyssa Schami Alyssa Schami M. Nurul Islam John T. Belisle Jordi B. Torrelles Jordi B. Torrelles |
| author_sort | Alyssa Schami |
| collection | DOAJ |
| description | In the past few decades, drug-resistant (DR) strains of Mycobacterium tuberculosis (M.tb), the causative agent of tuberculosis (TB), have become increasingly prevalent and pose a threat to worldwide public health. These strains range from multi (MDR) to extensively (XDR) drug-resistant, making them very difficult to treat. Further, the current and future impact of the Coronavirus Disease 2019 (COVID-19) pandemic on the development of DR-TB is still unknown. Although exhaustive studies have been conducted depicting the uniqueness of the M.tb cell envelope, little is known about how its composition changes in relation to drug resistance acquisition. This knowledge is critical to understanding the capacity of DR-M.tb strains to resist anti-TB drugs, and to inform us on the future design of anti-TB drugs to combat these difficult-to-treat strains. In this review, we discuss the complexities of the M.tb cell envelope along with recent studies investigating how M.tb structurally and biochemically changes in relation to drug resistance. Further, we will describe what is currently known about the influence of M.tb drug resistance on infection outcomes, focusing on its impact on fitness, persister-bacteria, and subclinical TB. |
| first_indexed | 2024-03-11T11:43:50Z |
| format | Article |
| id | doaj.art-955ec4360fcd4a1b91e395dd115a0479 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-11T11:43:50Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-955ec4360fcd4a1b91e395dd115a04792023-11-09T17:39:32ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-10-011310.3389/fcimb.2023.12741751274175Drug-resistant strains of Mycobacterium tuberculosis: cell envelope profiles and interactions with the hostAlyssa Schami0Alyssa Schami1M. Nurul Islam2John T. Belisle3Jordi B. Torrelles4Jordi B. Torrelles5Population Health Program, Texas Biomedical Research Institute, San Antonio, TX, United StatesIntegrated Biomedical Sciences Program, University of Texas Health Science Center at San Antonio, San Antonio, TX, United StatesMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United StatesMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United StatesPopulation Health Program, Texas Biomedical Research Institute, San Antonio, TX, United StatesInternational Center for the Advancement of Research & Education, International Center for the Advancement of Research & Education, Texas Biomedical Research Institute, San Antonio, TX, United StatesIn the past few decades, drug-resistant (DR) strains of Mycobacterium tuberculosis (M.tb), the causative agent of tuberculosis (TB), have become increasingly prevalent and pose a threat to worldwide public health. These strains range from multi (MDR) to extensively (XDR) drug-resistant, making them very difficult to treat. Further, the current and future impact of the Coronavirus Disease 2019 (COVID-19) pandemic on the development of DR-TB is still unknown. Although exhaustive studies have been conducted depicting the uniqueness of the M.tb cell envelope, little is known about how its composition changes in relation to drug resistance acquisition. This knowledge is critical to understanding the capacity of DR-M.tb strains to resist anti-TB drugs, and to inform us on the future design of anti-TB drugs to combat these difficult-to-treat strains. In this review, we discuss the complexities of the M.tb cell envelope along with recent studies investigating how M.tb structurally and biochemically changes in relation to drug resistance. Further, we will describe what is currently known about the influence of M.tb drug resistance on infection outcomes, focusing on its impact on fitness, persister-bacteria, and subclinical TB.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1274175/fullMycobacterium tuberculosistuberculosisdrug resistancecell envelope lipidsM.tb-host interactions |
| spellingShingle | Alyssa Schami Alyssa Schami M. Nurul Islam John T. Belisle Jordi B. Torrelles Jordi B. Torrelles Drug-resistant strains of Mycobacterium tuberculosis: cell envelope profiles and interactions with the host Frontiers in Cellular and Infection Microbiology Mycobacterium tuberculosis tuberculosis drug resistance cell envelope lipids M.tb-host interactions |
| title | Drug-resistant strains of Mycobacterium tuberculosis: cell envelope profiles and interactions with the host |
| title_full | Drug-resistant strains of Mycobacterium tuberculosis: cell envelope profiles and interactions with the host |
| title_fullStr | Drug-resistant strains of Mycobacterium tuberculosis: cell envelope profiles and interactions with the host |
| title_full_unstemmed | Drug-resistant strains of Mycobacterium tuberculosis: cell envelope profiles and interactions with the host |
| title_short | Drug-resistant strains of Mycobacterium tuberculosis: cell envelope profiles and interactions with the host |
| title_sort | drug resistant strains of mycobacterium tuberculosis cell envelope profiles and interactions with the host |
| topic | Mycobacterium tuberculosis tuberculosis drug resistance cell envelope lipids M.tb-host interactions |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1274175/full |
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