Metastasis Associated in Colorectal Cancer 1 (MACC1) mRNA Expression Is Enhanced in Sporadic Vestibular Schwannoma and Correlates to Deafness
Vestibular schwannoma (VS) are benign cranial nerve sheath tumors of the vestibulocochlear nerve. Their incidence is mostly sporadic, but they can also be associated with <i>NF2</i>-related schwannomatosis (NF2), a hereditary tumor syndrome. Metastasis associated in colon cancer 1 (MACC1...
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MDPI AG
2023-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/16/4089 |
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| author | Maria Breun Katharina Flock Jonas Feldheim Anja Nattmann Camelia M. Monoranu Pia Herrmann Ralf-Ingo Ernestus Mario Löhr Carsten Hagemann Ulrike Stein |
| author_facet | Maria Breun Katharina Flock Jonas Feldheim Anja Nattmann Camelia M. Monoranu Pia Herrmann Ralf-Ingo Ernestus Mario Löhr Carsten Hagemann Ulrike Stein |
| author_sort | Maria Breun |
| collection | DOAJ |
| description | Vestibular schwannoma (VS) are benign cranial nerve sheath tumors of the vestibulocochlear nerve. Their incidence is mostly sporadic, but they can also be associated with <i>NF2</i>-related schwannomatosis (NF2), a hereditary tumor syndrome. Metastasis associated in colon cancer 1 (MACC1) is known to contribute to angiogenesis, cell growth, invasiveness, cell motility and metastasis of solid malignant cancers. In addition, MACC1 may be associated with nonsyndromic hearing impairment. Therefore, we evaluated whether MACC1 may be involved in the pathogenesis of VS. Sporadic VS, recurrent sporadic VS, NF2-associated VS, recurrent NF2-associated VS and healthy vestibular nerves were analyzed for <i>MACC1</i> mRNA and protein expression by quantitative polymerase chain reaction and immunohistochemistry. <i>MACC1</i> expression levels were correlated with the patients’ clinical course and symptoms. <i>MACC1</i> mRNA expression was significantly higher in sporadic VS compared to NF2-associated VS (<i>p</i> < 0.001). The latter expressed similar MACC1 concentrations as healthy vestibular nerves. Recurrent tumors resembled the <i>MACC1</i> expression of the primary tumors. <i>MACC1</i> mRNA expression was significantly correlated with deafness in sporadic VS patients (<i>p</i> = 0.034). Therefore, MACC1 might be a new molecular marker involved in VS pathogenesis. |
| first_indexed | 2024-03-11T00:03:32Z |
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| id | doaj.art-955ecbabd2eb4a65bded7c8f445bc850 |
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| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T00:03:32Z |
| publishDate | 2023-08-01 |
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| record_format | Article |
| series | Cancers |
| spelling | doaj.art-955ecbabd2eb4a65bded7c8f445bc8502023-11-19T00:33:04ZengMDPI AGCancers2072-66942023-08-011516408910.3390/cancers15164089Metastasis Associated in Colorectal Cancer 1 (MACC1) mRNA Expression Is Enhanced in Sporadic Vestibular Schwannoma and Correlates to DeafnessMaria Breun0Katharina Flock1Jonas Feldheim2Anja Nattmann3Camelia M. Monoranu4Pia Herrmann5Ralf-Ingo Ernestus6Mario Löhr7Carsten Hagemann8Ulrike Stein9Section Experimental Neurosurgery, Department of Neurosurgery, University Hospital Würzburg, 97080 Würzburg, GermanySection Experimental Neurosurgery, Department of Neurosurgery, University Hospital Würzburg, 97080 Würzburg, GermanySection Experimental Neurosurgery, Department of Neurosurgery, University Hospital Würzburg, 97080 Würzburg, GermanySection Experimental Neurosurgery, Department of Neurosurgery, University Hospital Würzburg, 97080 Würzburg, GermanyInstitute of Pathology, Department of Neuropathology, University of Würzburg, 97080 Würzburg, GermanyExperimental and Clinical Research Center, Charité-Universitätsmedizin Berlin and Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, GermanySection Experimental Neurosurgery, Department of Neurosurgery, University Hospital Würzburg, 97080 Würzburg, GermanySection Experimental Neurosurgery, Department of Neurosurgery, University Hospital Würzburg, 97080 Würzburg, GermanySection Experimental Neurosurgery, Department of Neurosurgery, University Hospital Würzburg, 97080 Würzburg, GermanyExperimental and Clinical Research Center, Charité-Universitätsmedizin Berlin and Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, GermanyVestibular schwannoma (VS) are benign cranial nerve sheath tumors of the vestibulocochlear nerve. Their incidence is mostly sporadic, but they can also be associated with <i>NF2</i>-related schwannomatosis (NF2), a hereditary tumor syndrome. Metastasis associated in colon cancer 1 (MACC1) is known to contribute to angiogenesis, cell growth, invasiveness, cell motility and metastasis of solid malignant cancers. In addition, MACC1 may be associated with nonsyndromic hearing impairment. Therefore, we evaluated whether MACC1 may be involved in the pathogenesis of VS. Sporadic VS, recurrent sporadic VS, NF2-associated VS, recurrent NF2-associated VS and healthy vestibular nerves were analyzed for <i>MACC1</i> mRNA and protein expression by quantitative polymerase chain reaction and immunohistochemistry. <i>MACC1</i> expression levels were correlated with the patients’ clinical course and symptoms. <i>MACC1</i> mRNA expression was significantly higher in sporadic VS compared to NF2-associated VS (<i>p</i> < 0.001). The latter expressed similar MACC1 concentrations as healthy vestibular nerves. Recurrent tumors resembled the <i>MACC1</i> expression of the primary tumors. <i>MACC1</i> mRNA expression was significantly correlated with deafness in sporadic VS patients (<i>p</i> = 0.034). Therefore, MACC1 might be a new molecular marker involved in VS pathogenesis.https://www.mdpi.com/2072-6694/15/16/4089vestibular schwannomametastasis associated in colorectal cancer 1 (MACC1)pathogenesisdeafnessNF2-related schwannomatosis (NF2)mRNA expression |
| spellingShingle | Maria Breun Katharina Flock Jonas Feldheim Anja Nattmann Camelia M. Monoranu Pia Herrmann Ralf-Ingo Ernestus Mario Löhr Carsten Hagemann Ulrike Stein Metastasis Associated in Colorectal Cancer 1 (MACC1) mRNA Expression Is Enhanced in Sporadic Vestibular Schwannoma and Correlates to Deafness Cancers vestibular schwannoma metastasis associated in colorectal cancer 1 (MACC1) pathogenesis deafness NF2-related schwannomatosis (NF2) mRNA expression |
| title | Metastasis Associated in Colorectal Cancer 1 (MACC1) mRNA Expression Is Enhanced in Sporadic Vestibular Schwannoma and Correlates to Deafness |
| title_full | Metastasis Associated in Colorectal Cancer 1 (MACC1) mRNA Expression Is Enhanced in Sporadic Vestibular Schwannoma and Correlates to Deafness |
| title_fullStr | Metastasis Associated in Colorectal Cancer 1 (MACC1) mRNA Expression Is Enhanced in Sporadic Vestibular Schwannoma and Correlates to Deafness |
| title_full_unstemmed | Metastasis Associated in Colorectal Cancer 1 (MACC1) mRNA Expression Is Enhanced in Sporadic Vestibular Schwannoma and Correlates to Deafness |
| title_short | Metastasis Associated in Colorectal Cancer 1 (MACC1) mRNA Expression Is Enhanced in Sporadic Vestibular Schwannoma and Correlates to Deafness |
| title_sort | metastasis associated in colorectal cancer 1 macc1 mrna expression is enhanced in sporadic vestibular schwannoma and correlates to deafness |
| topic | vestibular schwannoma metastasis associated in colorectal cancer 1 (MACC1) pathogenesis deafness NF2-related schwannomatosis (NF2) mRNA expression |
| url | https://www.mdpi.com/2072-6694/15/16/4089 |
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