Associations between maternal and offspring glucose metabolism: a 9-year follow-up of a randomised controlled trial
IntroductionThere is increasing evidence that the in utero environment affects the health and disease risk of offspring throughout their lives. The long-term effect of maternal hyperglycaemia on offspring glucose metabolism is of interest in a public health perspective. The aim of this study was to...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1324925/full |
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| author | Sigrid L. Nyen Astrid Kamilla Stunes Astrid Kamilla Stunes Kari Anne I. Evensen Kari Anne I. Evensen Kari Anne I. Evensen Torunn Børsting Torunn Børsting Unni Syversen Unni Syversen Kjell Å. Salvesen Kjell Å. Salvesen Siv Mørkved Siv Mørkved Signe N. Stafne Signe N. Stafne |
| author_facet | Sigrid L. Nyen Astrid Kamilla Stunes Astrid Kamilla Stunes Kari Anne I. Evensen Kari Anne I. Evensen Kari Anne I. Evensen Torunn Børsting Torunn Børsting Unni Syversen Unni Syversen Kjell Å. Salvesen Kjell Å. Salvesen Siv Mørkved Siv Mørkved Signe N. Stafne Signe N. Stafne |
| author_sort | Sigrid L. Nyen |
| collection | DOAJ |
| description | IntroductionThere is increasing evidence that the in utero environment affects the health and disease risk of offspring throughout their lives. The long-term effect of maternal hyperglycaemia on offspring glucose metabolism is of interest in a public health perspective. The aim of this study was to examine the association between in utero exposure to maternal glycaemia and offspring glucose metabolism.MethodsMother-child pairs were recruited from an RCT to prevent gestational diabetes mellitus where 855 healthy pregnant women were randomised to exercise or standard antenatal care. The original RCT detected no group differences in gestational diabetes mellitus prevalence or insulin resistance. The two groups were analysed as one group in the present study. Maternal glucose levels were assessed after 2-hour 75-gram oral glucose tolerance tests in pregnancy week ~34. Offspring outcomes were evaluated at ~9 years of age and included fasting glucose and homeostatic model assessment of insulin resistance. Multivariable regression models were performed, controlling for potential hereditary and lifestyle confounding factors.ResultsComplete data were available for 105 mother-child pairs. The regression analysis showed a positive association between maternal and offspring fasting glucose that was borderline significant (beta=0.18, 95% CI [-0.00027, 0.37], p=0.050). We did not find significant associations between maternal fasting glucose and offspring insulin resistance (beta=0.080, 95% CI [-0.087, 0.25], p=0.34), or between maternal 2-hour glucose and offspring fasting glucose (beta=0.016, 95% CI [-0.038, 0.070], p=0.56) or insulin resistance (beta=0.017, 95% CI [-0.032, 0.065], p=0.49).ConclusionsAssessing a homogeneous group of healthy mother-child pairs, we found a borderline significant positive association between maternal and offspring fasting glucose, which persisted after adjustment for potential hereditary and lifestyle confounding factors. Our findings support other similar studies and highlight that improving the metabolic health of pregnant women, and women in childbearing age, should remain a key public health priority.Clinical trial registrationClinicalTrials.gov, identifier NCT00476567. |
| first_indexed | 2024-03-08T15:25:40Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-08T15:25:40Z |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-9564503dd341426cbb4c336cd49847872024-01-10T10:14:25ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011410.3389/fendo.2023.13249251324925Associations between maternal and offspring glucose metabolism: a 9-year follow-up of a randomised controlled trialSigrid L. Nyen0Astrid Kamilla Stunes1Astrid Kamilla Stunes2Kari Anne I. Evensen3Kari Anne I. Evensen4Kari Anne I. Evensen5Torunn Børsting6Torunn Børsting7Unni Syversen8Unni Syversen9Kjell Å. Salvesen10Kjell Å. Salvesen11Siv Mørkved12Siv Mørkved13Signe N. Stafne14Signe N. Stafne15Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayCenter for Oral Health Services and Research, Mid-Norway (TkMidt), Trondheim, NorwayDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayChildren’s Clinic, St. Olavs Hospital, Trondheim University Hospital, Trondheim, NorwayDepartment of Rehabilitation Science and Health Technology, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, NorwayCenter for Oral Health Services and Research, Mid-Norway (TkMidt), Trondheim, NorwayDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayDepartment of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, NorwayDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayDepartment of Obstetrics and Gynecology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, NorwayDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayClinic of Rehabilitation, St. Olavs Hospital, Trondheim University Hospital, Trondheim, NorwayDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayClinic of Rehabilitation, St. Olavs Hospital, Trondheim University Hospital, Trondheim, NorwayIntroductionThere is increasing evidence that the in utero environment affects the health and disease risk of offspring throughout their lives. The long-term effect of maternal hyperglycaemia on offspring glucose metabolism is of interest in a public health perspective. The aim of this study was to examine the association between in utero exposure to maternal glycaemia and offspring glucose metabolism.MethodsMother-child pairs were recruited from an RCT to prevent gestational diabetes mellitus where 855 healthy pregnant women were randomised to exercise or standard antenatal care. The original RCT detected no group differences in gestational diabetes mellitus prevalence or insulin resistance. The two groups were analysed as one group in the present study. Maternal glucose levels were assessed after 2-hour 75-gram oral glucose tolerance tests in pregnancy week ~34. Offspring outcomes were evaluated at ~9 years of age and included fasting glucose and homeostatic model assessment of insulin resistance. Multivariable regression models were performed, controlling for potential hereditary and lifestyle confounding factors.ResultsComplete data were available for 105 mother-child pairs. The regression analysis showed a positive association between maternal and offspring fasting glucose that was borderline significant (beta=0.18, 95% CI [-0.00027, 0.37], p=0.050). We did not find significant associations between maternal fasting glucose and offspring insulin resistance (beta=0.080, 95% CI [-0.087, 0.25], p=0.34), or between maternal 2-hour glucose and offspring fasting glucose (beta=0.016, 95% CI [-0.038, 0.070], p=0.56) or insulin resistance (beta=0.017, 95% CI [-0.032, 0.065], p=0.49).ConclusionsAssessing a homogeneous group of healthy mother-child pairs, we found a borderline significant positive association between maternal and offspring fasting glucose, which persisted after adjustment for potential hereditary and lifestyle confounding factors. Our findings support other similar studies and highlight that improving the metabolic health of pregnant women, and women in childbearing age, should remain a key public health priority.Clinical trial registrationClinicalTrials.gov, identifier NCT00476567.https://www.frontiersin.org/articles/10.3389/fendo.2023.1324925/fullblood glucosechildfollow-upgestational diabeteshyperglycaemiainsulin resistance |
| spellingShingle | Sigrid L. Nyen Astrid Kamilla Stunes Astrid Kamilla Stunes Kari Anne I. Evensen Kari Anne I. Evensen Kari Anne I. Evensen Torunn Børsting Torunn Børsting Unni Syversen Unni Syversen Kjell Å. Salvesen Kjell Å. Salvesen Siv Mørkved Siv Mørkved Signe N. Stafne Signe N. Stafne Associations between maternal and offspring glucose metabolism: a 9-year follow-up of a randomised controlled trial Frontiers in Endocrinology blood glucose child follow-up gestational diabetes hyperglycaemia insulin resistance |
| title | Associations between maternal and offspring glucose metabolism: a 9-year follow-up of a randomised controlled trial |
| title_full | Associations between maternal and offspring glucose metabolism: a 9-year follow-up of a randomised controlled trial |
| title_fullStr | Associations between maternal and offspring glucose metabolism: a 9-year follow-up of a randomised controlled trial |
| title_full_unstemmed | Associations between maternal and offspring glucose metabolism: a 9-year follow-up of a randomised controlled trial |
| title_short | Associations between maternal and offspring glucose metabolism: a 9-year follow-up of a randomised controlled trial |
| title_sort | associations between maternal and offspring glucose metabolism a 9 year follow up of a randomised controlled trial |
| topic | blood glucose child follow-up gestational diabetes hyperglycaemia insulin resistance |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1324925/full |
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