The Combination of ATM and Chk1 Inhibitors Induces Synthetic Lethality in Colorectal Cancer Cells

The Combination of ATM and Chk1 Inhibitors Induces Synthetic Lethality in Colorectal Cancer Cells

Genetic abnormalities induce the DNA damage response (DDR), which enables DNA repair at cell cycle checkpoints. Although the DDR is thought to function in preventing the onset and progression of cancer, DDR-related proteins are also thought to contribute to tumorigenesis, tumor progression, and drug...

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Bibliographic Details
Main Authors: Yuri Tozaki, Hiromasa Aoki, Rina Kato, Kohki Toriuchi, Saki Arame, Yasumichi Inoue, Hidetoshi Hayashi, Eiji Kubota, Hiromi Kataoka, Mineyoshi Aoyama
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
ATM
Chk1
CDK1
cancer therapies
cell cycle checkpoint
synthetic lethality
Online Access:https://www.mdpi.com/2072-6694/15/3/735

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