Enhanced Activation of the S1PR2-IL-1β-Src-BDNF-TrkB Pathway Mediates Neuroinflammation in the Hippocampus and Cognitive Impairment in Hyperammonemic Rats

Enhanced Activation of the S1PR2-IL-1β-Src-BDNF-TrkB Pathway Mediates Neuroinflammation in the Hippocampus and Cognitive Impairment in Hyperammonemic Rats

Hyperammonemia contributes to hepatic encephalopathy. In hyperammonemic rats, cognitive function is impaired by altered glutamatergic neurotransmission induced by neuroinflammation. The underlying mechanisms remain unclear. Enhanced sphingosine-1-phosphate receptor 2 (S1PR2) activation in the cerebe...

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Bibliographic Details
Main Authors:	María Sancho-Alonso, Yaiza M. Arenas, Paula Izquierdo-Altarejos, Mar Martinez-Garcia, Marta Llansola, Vicente Felipo
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Series:	International Journal of Molecular Sciences
Subjects:	hepatic encephalopathy cognitive impairment neuroinflammation sphingosine-1-phosphate glutamate receptor BDNF
Online Access:	https://www.mdpi.com/1422-0067/24/24/17251

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