Effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosis
Osteoporosis stands out as a prevalent metabolic disorder, bearing significant repercussions on human well-being and overall quality of life. It remains an urgent concern within the global public health framework due to its widespread occurrence. Osteoporosis arises from an abnormal metabolism in os...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1289843/full |
| _version_ | 1797643273036103680 |
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| author | Guochen Wang Guochen Wang Yubo Meng Yubo Meng Wensi Ouyang Wensi Ouyang Changwei Zhao Changwei Zhao Wenhai Zhao Wenhai Zhao |
| author_facet | Guochen Wang Guochen Wang Yubo Meng Yubo Meng Wensi Ouyang Wensi Ouyang Changwei Zhao Changwei Zhao Wenhai Zhao Wenhai Zhao |
| author_sort | Guochen Wang |
| collection | DOAJ |
| description | Osteoporosis stands out as a prevalent metabolic disorder, bearing significant repercussions on human well-being and overall quality of life. It remains an urgent concern within the global public health framework due to its widespread occurrence. Osteoporosis arises from an abnormal metabolism in osteoblasts and osteoclasts, resulting in a disruption of the delicate equilibrium between bone formation and bone resorption. Within this context, deer antler peptides emerge as natural active compounds, wielding a pivotal role in governing the differentiation, proliferation, and mineralization of osteoblasts, as well as influencing the activity of osteoclasts. This article aims to consolidate our comprehension of the mechanisms underpinning the dynamic balance between bone formation and resorption, meticulously orchestrated by osteoblasts and osteoclasts in osteoporosis. Furthermore, it offers a comprehensive overview of how deer antler peptides, through their modulation of relevant signaling pathways, contribute to the enhancement of bone homeostasis. These insights deepen our understanding of the pathological processes through which deer antler peptides ameliorate bone homeostasis, while also presenting novel strategies for osteoporosis management. |
| first_indexed | 2024-03-11T14:12:22Z |
| format | Article |
| id | doaj.art-956b0fb9abaf46a3b3982648cea290e8 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-11T14:12:22Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-956b0fb9abaf46a3b3982648cea290e82023-11-01T17:31:33ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-11-011010.3389/fmed.2023.12898431289843Effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosisGuochen Wang0Guochen Wang1Yubo Meng2Yubo Meng3Wensi Ouyang4Wensi Ouyang5Changwei Zhao6Changwei Zhao7Wenhai Zhao8Wenhai Zhao9Changchun University of Chinese Medicine, Changchun, ChinaCollege of Traditonal Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaCollege of Traditonal Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaThe Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, ChinaChangchun University of Chinese Medicine, Changchun, ChinaCollege of Traditonal Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaCollege of Traditonal Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaThe Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, ChinaCollege of Traditonal Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaThe Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, ChinaOsteoporosis stands out as a prevalent metabolic disorder, bearing significant repercussions on human well-being and overall quality of life. It remains an urgent concern within the global public health framework due to its widespread occurrence. Osteoporosis arises from an abnormal metabolism in osteoblasts and osteoclasts, resulting in a disruption of the delicate equilibrium between bone formation and bone resorption. Within this context, deer antler peptides emerge as natural active compounds, wielding a pivotal role in governing the differentiation, proliferation, and mineralization of osteoblasts, as well as influencing the activity of osteoclasts. This article aims to consolidate our comprehension of the mechanisms underpinning the dynamic balance between bone formation and resorption, meticulously orchestrated by osteoblasts and osteoclasts in osteoporosis. Furthermore, it offers a comprehensive overview of how deer antler peptides, through their modulation of relevant signaling pathways, contribute to the enhancement of bone homeostasis. These insights deepen our understanding of the pathological processes through which deer antler peptides ameliorate bone homeostasis, while also presenting novel strategies for osteoporosis management.https://www.frontiersin.org/articles/10.3389/fmed.2023.1289843/fullosteoporosisbone homeostasispilose antler polypeptideosteoblastsosteoclast |
| spellingShingle | Guochen Wang Guochen Wang Yubo Meng Yubo Meng Wensi Ouyang Wensi Ouyang Changwei Zhao Changwei Zhao Wenhai Zhao Wenhai Zhao Effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosis Frontiers in Medicine osteoporosis bone homeostasis pilose antler polypeptide osteoblasts osteoclast |
| title | Effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosis |
| title_full | Effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosis |
| title_fullStr | Effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosis |
| title_full_unstemmed | Effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosis |
| title_short | Effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosis |
| title_sort | effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosis |
| topic | osteoporosis bone homeostasis pilose antler polypeptide osteoblasts osteoclast |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1289843/full |
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