Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly
Renee Hartog,1,* Davide Bolignano,1,2,* Eric Sijbrands,1 Giacomo Pucci,3,4 Francesco Mattace-Raso1 1Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; 2Institute of Clinical Physiology, Italian National Council of Research, Reggio Calabria, Italy; 3Depar...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-04-01
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| Series: | Clinical Interventions in Aging |
| Subjects: | |
| Online Access: | https://www.dovepress.com/short-term-vascular-hemodynamic-responses-to-isometric-exercise-in-you-peer-reviewed-article-CIA |
| _version_ | 1818742594060943360 |
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| author | Hartog R Bolignano D Sijbrands E Pucci G Mattace-Raso F |
| author_facet | Hartog R Bolignano D Sijbrands E Pucci G Mattace-Raso F |
| author_sort | Hartog R |
| collection | DOAJ |
| description | Renee Hartog,1,* Davide Bolignano,1,2,* Eric Sijbrands,1 Giacomo Pucci,3,4 Francesco Mattace-Raso1 1Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; 2Institute of Clinical Physiology, Italian National Council of Research, Reggio Calabria, Italy; 3Department of Medicine, University of Perugia, Perugia, Italy; 4Unit of Internal Medicine, Terni University Hospital, Terni, Italy *These authors contributed equally to this work Background: Vascular aging is known to induce progressive stiffening of the large elastic arteries, altering vascular hemodynamics under both rest and stress conditions. In this study, we aimed to investigate changes in vascular hemodynamics in response to isometric handgrip exercise across ages.Participants and methods: We included 62 participants, who were divided into three age categories: 20–40 (n=22), 41–60 (n=20), and 61–80 (n=20) years. Vascular hemodynamics were measured using the Mobil-o-Graph® based on the pulsatile pressure changes in the brachial artery. One-way ANOVA test was performed to analyze the changes induced by isometric handgrip exercise.Results: After isometric handgrip exercise, aortic pulse wave velocity (PWV) increased by 0.10 m/s in the youngest, 0.06 m/s in the middle-age, and 0.02 m/s in the oldest age category. Changes in PWV strongly correlated with those in central systolic blood pressure (cSBP) (r=0.878, P<0.01). After isometric exercise, the mean change of systolic blood pressure (SBP) was -1.9% in the youngest, 0.6% in the middle-aged, and 8.2% in the oldest subjects. Increasing handgrip strength was associated with an increase in SBP and cSBP (1.08 and 1.37 mmHg per 1 kg increase in handgrip strength, respectively, P=0.01). Finally, PWV was significantly associated with increasing handgrip strength with an increase of 0.05 m/s per 1 kg higher handgrip strength (P=0.01).Conclusion: This study found increased blood pressure levels after isometric challenge and a strong association between handgrip strength and change in blood pressure levels and aortic stiffness in elderly subjects. Keywords: vascular aging, isometric stress, blood pressure, pulse wave velocity |
| first_indexed | 2024-12-18T02:15:00Z |
| format | Article |
| id | doaj.art-956c576d49e544da9455d937de18e2f1 |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-18T02:15:00Z |
| publishDate | 2018-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-956c576d49e544da9455d937de18e2f12022-12-21T21:24:25ZengDove Medical PressClinical Interventions in Aging1178-19982018-04-01Volume 1350951437533Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderlyHartog RBolignano DSijbrands EPucci GMattace-Raso FRenee Hartog,1,* Davide Bolignano,1,2,* Eric Sijbrands,1 Giacomo Pucci,3,4 Francesco Mattace-Raso1 1Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands; 2Institute of Clinical Physiology, Italian National Council of Research, Reggio Calabria, Italy; 3Department of Medicine, University of Perugia, Perugia, Italy; 4Unit of Internal Medicine, Terni University Hospital, Terni, Italy *These authors contributed equally to this work Background: Vascular aging is known to induce progressive stiffening of the large elastic arteries, altering vascular hemodynamics under both rest and stress conditions. In this study, we aimed to investigate changes in vascular hemodynamics in response to isometric handgrip exercise across ages.Participants and methods: We included 62 participants, who were divided into three age categories: 20–40 (n=22), 41–60 (n=20), and 61–80 (n=20) years. Vascular hemodynamics were measured using the Mobil-o-Graph® based on the pulsatile pressure changes in the brachial artery. One-way ANOVA test was performed to analyze the changes induced by isometric handgrip exercise.Results: After isometric handgrip exercise, aortic pulse wave velocity (PWV) increased by 0.10 m/s in the youngest, 0.06 m/s in the middle-age, and 0.02 m/s in the oldest age category. Changes in PWV strongly correlated with those in central systolic blood pressure (cSBP) (r=0.878, P<0.01). After isometric exercise, the mean change of systolic blood pressure (SBP) was -1.9% in the youngest, 0.6% in the middle-aged, and 8.2% in the oldest subjects. Increasing handgrip strength was associated with an increase in SBP and cSBP (1.08 and 1.37 mmHg per 1 kg increase in handgrip strength, respectively, P=0.01). Finally, PWV was significantly associated with increasing handgrip strength with an increase of 0.05 m/s per 1 kg higher handgrip strength (P=0.01).Conclusion: This study found increased blood pressure levels after isometric challenge and a strong association between handgrip strength and change in blood pressure levels and aortic stiffness in elderly subjects. Keywords: vascular aging, isometric stress, blood pressure, pulse wave velocity https://www.dovepress.com/short-term-vascular-hemodynamic-responses-to-isometric-exercise-in-you-peer-reviewed-article-CIAvascular agingisometric stressblood pressurepulse wave velocity |
| spellingShingle | Hartog R Bolignano D Sijbrands E Pucci G Mattace-Raso F Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly Clinical Interventions in Aging vascular aging isometric stress blood pressure pulse wave velocity |
| title | Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly |
| title_full | Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly |
| title_fullStr | Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly |
| title_full_unstemmed | Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly |
| title_short | Short-term vascular hemodynamic responses to isometric exercise in young adults and in the elderly |
| title_sort | short term vascular hemodynamic responses to isometric exercise in young adults and in the elderly |
| topic | vascular aging isometric stress blood pressure pulse wave velocity |
| url | https://www.dovepress.com/short-term-vascular-hemodynamic-responses-to-isometric-exercise-in-you-peer-reviewed-article-CIA |
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