The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer’s Disease Mouse Model
Alzheimer’s disease (AD) is the main cause of dementia worldwide. Emerging non-invasive treatments such as photobiomodulation target the mitochondria to minimize brain damage, improving cognitive functions. In this work, an experimental design was carried out to evaluate the effect of transcranial l...
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MDPI AG
2022-09-01
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| author | Débora Buendía Tatiana Guncay Macarena Oyanedel Makarena Lemus Alejandro Weinstein Álvaro O. Ardiles José Marcos Adriana Fernandes Renato Zângaro Pablo Muñoz |
| author_facet | Débora Buendía Tatiana Guncay Macarena Oyanedel Makarena Lemus Alejandro Weinstein Álvaro O. Ardiles José Marcos Adriana Fernandes Renato Zângaro Pablo Muñoz |
| author_sort | Débora Buendía |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is the main cause of dementia worldwide. Emerging non-invasive treatments such as photobiomodulation target the mitochondria to minimize brain damage, improving cognitive functions. In this work, an experimental design was carried out to evaluate the effect of transcranial light therapy (TLTC) on synaptic plasticity (SP) and cognitive functions in an AD animal model. Twenty-three mice were separated into two general groups: an APP/PS1 (ALZ) transgenic group and a wild-type (WT) group. Each group was randomly subdivided into two subgroups: mice with and without TLTC, depending on whether they would undergo treatment with TLTC. Cognitive function, measured through an object recognition task, showed non-significant improvement after TLTC. SP, on the other hand, was evaluated using four electrophysiological parameters from the Schaffer-CA1 collateral hippocampal synapses: excitatory field potentials (fEPSP), paired pulse facilitation (PPF), long-term depression (LTD), and long-term potentiation (LTP). An improvement was observed in subjects treated with TLTC, showing higher levels of LTP than those transgenic mice that were not exposed to the treatment. Therefore, the results obtained in this work showed that TLTC could be an efficient non-invasive treatment for AD-associated SP deficits. |
| first_indexed | 2024-03-09T20:35:08Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T20:35:08Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
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| series | Brain Sciences |
| spelling | doaj.art-956e26e4626b4ed1b33c2846d507e4df2023-11-23T23:12:46ZengMDPI AGBrain Sciences2076-34252022-09-011210127210.3390/brainsci12101272The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer’s Disease Mouse ModelDébora Buendía0Tatiana Guncay1Macarena Oyanedel2Makarena Lemus3Alejandro Weinstein4Álvaro O. Ardiles5José Marcos6Adriana Fernandes7Renato Zângaro8Pablo Muñoz9Programa de Engenharia Biomédica, Instituto de Engenharia Biomédica, Universidade Anhembi Morumbi—UAM, Rua Casa do Ator, 294, Sao Paulo 04546-001, BrazilCentro de Neurología Traslacional, Facultad de Medicina, Universidad de Valparaíso, Valparaíso 2341386, ChileEscuela de Ingeniería Civil Biomédica, Facultad de Ingeniería, Universidad de Valparaíso, General Cruz 222, Valparaíso 2362905, ChileEscuela de Ingeniería Civil Biomédica, Facultad de Ingeniería, Universidad de Valparaíso, General Cruz 222, Valparaíso 2362905, ChileEscuela de Ingeniería Civil Biomédica, Facultad de Ingeniería, Universidad de Valparaíso, General Cruz 222, Valparaíso 2362905, ChileCentro de Neurología Traslacional, Facultad de Medicina, Universidad de Valparaíso, Valparaíso 2341386, ChileCentro de Neurología Traslacional, Facultad de Medicina, Universidad de Valparaíso, Valparaíso 2341386, ChilePrograma de Engenharia Biomédica, Instituto de Engenharia Biomédica, Universidade Anhembi Morumbi—UAM, Rua Casa do Ator, 294, Sao Paulo 04546-001, BrazilPrograma de Engenharia Biomédica, Instituto de Engenharia Biomédica, Universidade Anhembi Morumbi—UAM, Rua Casa do Ator, 294, Sao Paulo 04546-001, BrazilCentro de Neurología Traslacional, Facultad de Medicina, Universidad de Valparaíso, Valparaíso 2341386, ChileAlzheimer’s disease (AD) is the main cause of dementia worldwide. Emerging non-invasive treatments such as photobiomodulation target the mitochondria to minimize brain damage, improving cognitive functions. In this work, an experimental design was carried out to evaluate the effect of transcranial light therapy (TLTC) on synaptic plasticity (SP) and cognitive functions in an AD animal model. Twenty-three mice were separated into two general groups: an APP/PS1 (ALZ) transgenic group and a wild-type (WT) group. Each group was randomly subdivided into two subgroups: mice with and without TLTC, depending on whether they would undergo treatment with TLTC. Cognitive function, measured through an object recognition task, showed non-significant improvement after TLTC. SP, on the other hand, was evaluated using four electrophysiological parameters from the Schaffer-CA1 collateral hippocampal synapses: excitatory field potentials (fEPSP), paired pulse facilitation (PPF), long-term depression (LTD), and long-term potentiation (LTP). An improvement was observed in subjects treated with TLTC, showing higher levels of LTP than those transgenic mice that were not exposed to the treatment. Therefore, the results obtained in this work showed that TLTC could be an efficient non-invasive treatment for AD-associated SP deficits.https://www.mdpi.com/2076-3425/12/10/1272Alzheimer’s diseasetranscranial light therapyLLLTsynaptic plasticitycognitive functionsAlzheimer’s disease non-invasive treatment |
| spellingShingle | Débora Buendía Tatiana Guncay Macarena Oyanedel Makarena Lemus Alejandro Weinstein Álvaro O. Ardiles José Marcos Adriana Fernandes Renato Zângaro Pablo Muñoz The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer’s Disease Mouse Model Brain Sciences Alzheimer’s disease transcranial light therapy LLLT synaptic plasticity cognitive functions Alzheimer’s disease non-invasive treatment |
| title | The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer’s Disease Mouse Model |
| title_full | The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer’s Disease Mouse Model |
| title_fullStr | The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer’s Disease Mouse Model |
| title_full_unstemmed | The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer’s Disease Mouse Model |
| title_short | The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer’s Disease Mouse Model |
| title_sort | transcranial light therapy improves synaptic plasticity in the alzheimer s disease mouse model |
| topic | Alzheimer’s disease transcranial light therapy LLLT synaptic plasticity cognitive functions Alzheimer’s disease non-invasive treatment |
| url | https://www.mdpi.com/2076-3425/12/10/1272 |
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