The Universal Theory for Multiscale Modelling of Infectious Disease Dynamics
The replication-transmission relativity theory, currently used to inform the development of multiscale models of infectious disease dynamics, needs a revision and extension to accommodate new basic science and clinical information about infectious disease dynamics. In this article, we revise and ext...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Mathematics |
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| Online Access: | https://www.mdpi.com/2227-7390/11/18/3874 |
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| author | Winston Garira Kizito Muzhinji |
| author_facet | Winston Garira Kizito Muzhinji |
| author_sort | Winston Garira |
| collection | DOAJ |
| description | The replication-transmission relativity theory, currently used to inform the development of multiscale models of infectious disease dynamics, needs a revision and extension to accommodate new basic science and clinical information about infectious disease dynamics. In this article, we revise and extend the replication-transmission relativity theory into a new scientific theory of infectious disease dynamics called the universal theory for the multiscale modelling of infectious disease dynamics. This new theory states that, for every host–pathogen interaction that results in an infectious disease system, there is no privileged or absolute scale of a disease system form that would determine the dynamics of the infectious disease system, only interactions between the scales of a level of organisation of the pathogen-centred disease system form and the scales of the corresponding levels of organisation of the host-centred disease system form. We further explain the utility of this theory, which is reflected in its flexibility and ability to incorporate new information and explain previous information that could not be accounted for by the replication-transmission relativity theory of infectious disease dynamics. |
| first_indexed | 2024-03-10T22:30:11Z |
| format | Article |
| id | doaj.art-956eef18d89d42a6abd1e858f1a02371 |
| institution | Directory Open Access Journal |
| issn | 2227-7390 |
| language | English |
| last_indexed | 2024-03-10T22:30:11Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Mathematics |
| spelling | doaj.art-956eef18d89d42a6abd1e858f1a023712023-11-19T11:48:48ZengMDPI AGMathematics2227-73902023-09-011118387410.3390/math11183874The Universal Theory for Multiscale Modelling of Infectious Disease DynamicsWinston Garira0Kizito Muzhinji1Modelling Health and Environmental Linkages Research Group (MHELRG), Department of Mathematical and Computational Sciences, University of Venda, Private Bag X5050, Thohoyandou 0950, South AfricaModelling Health and Environmental Linkages Research Group (MHELRG), Department of Mathematical and Computational Sciences, University of Venda, Private Bag X5050, Thohoyandou 0950, South AfricaThe replication-transmission relativity theory, currently used to inform the development of multiscale models of infectious disease dynamics, needs a revision and extension to accommodate new basic science and clinical information about infectious disease dynamics. In this article, we revise and extend the replication-transmission relativity theory into a new scientific theory of infectious disease dynamics called the universal theory for the multiscale modelling of infectious disease dynamics. This new theory states that, for every host–pathogen interaction that results in an infectious disease system, there is no privileged or absolute scale of a disease system form that would determine the dynamics of the infectious disease system, only interactions between the scales of a level of organisation of the pathogen-centred disease system form and the scales of the corresponding levels of organisation of the host-centred disease system form. We further explain the utility of this theory, which is reflected in its flexibility and ability to incorporate new information and explain previous information that could not be accounted for by the replication-transmission relativity theory of infectious disease dynamics.https://www.mdpi.com/2227-7390/11/18/3874multiscale modelling of infectious disease dynamicsthe replication-transmission relativity theory of infectious disease dynamicspathogen-centred disease system formhost-centred disease system formmultiscale modelling of malaria disease system |
| spellingShingle | Winston Garira Kizito Muzhinji The Universal Theory for Multiscale Modelling of Infectious Disease Dynamics Mathematics multiscale modelling of infectious disease dynamics the replication-transmission relativity theory of infectious disease dynamics pathogen-centred disease system form host-centred disease system form multiscale modelling of malaria disease system |
| title | The Universal Theory for Multiscale Modelling of Infectious Disease Dynamics |
| title_full | The Universal Theory for Multiscale Modelling of Infectious Disease Dynamics |
| title_fullStr | The Universal Theory for Multiscale Modelling of Infectious Disease Dynamics |
| title_full_unstemmed | The Universal Theory for Multiscale Modelling of Infectious Disease Dynamics |
| title_short | The Universal Theory for Multiscale Modelling of Infectious Disease Dynamics |
| title_sort | universal theory for multiscale modelling of infectious disease dynamics |
| topic | multiscale modelling of infectious disease dynamics the replication-transmission relativity theory of infectious disease dynamics pathogen-centred disease system form host-centred disease system form multiscale modelling of malaria disease system |
| url | https://www.mdpi.com/2227-7390/11/18/3874 |
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