Virtual reality cognitive intervention for heart failure: CORE study protocol
Abstract Introduction Heart failure (HF) is a prevalent, serious chronic illness that affects 6.5 million adults in the United States. Among patients with HF, the prevalence of attention impairment is reported to range from 15% to 27%. Although attention is fundamental to human activities including...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/trc2.12230 |
| _version_ | 1826950790188630016 |
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| author | Miyeon Jung Liana G. Apostolova Debra K. Moser Irmina Gradus‐Pizlo Sujuan Gao Jeff L. Rogers Susan J. Pressler |
| author_facet | Miyeon Jung Liana G. Apostolova Debra K. Moser Irmina Gradus‐Pizlo Sujuan Gao Jeff L. Rogers Susan J. Pressler |
| author_sort | Miyeon Jung |
| collection | DOAJ |
| description | Abstract Introduction Heart failure (HF) is a prevalent, serious chronic illness that affects 6.5 million adults in the United States. Among patients with HF, the prevalence of attention impairment is reported to range from 15% to 27%. Although attention is fundamental to human activities including HF self‐care, cognitive interventions for patients with HF that target improvement in attention are scarce. The COgnitive intervention to Restore attention using nature Environment (CORE) study aims to test the preliminary efficacy of the newly developed Nature‐VR, a virtual reality‐based cognitive intervention that is based on the restorative effects of nature. Nature‐VR development was guided by Attention Restoration Theory. The target outcomes are attention, HF self‐care, and health‐related quality of life (HRQoL). Our exploratory aims examine the associations between attention and several putative/established HF biomarkers (eg, oxygen saturation, brain‐derived neurotrophic factor, apolipoprotein E, dopamine receptor, and dopamine transporter genes) as well as the effect of Nature‐VR on cognitive performance in other domains (ie, global cognition, memory, visuospatial, executive function, and language), cardiac and neurological events, and mortality. Methods This single‐blinded, two‐group randomized‐controlled pilot study will enroll 74 participants with HF. The Nature‐VR intervention group will view three‐dimensional nature pictures using a virtual reality headset for 10 minutes per day, 5 days per week for 4 weeks (a total of 200 minutes). The active comparison group, Urban‐VR, will view three‐dimensional urban pictures using a virtual reality headset to match the Nature‐VR intervention in intervention dose and delivery mode, but not in content. After baseline interviews, four follow‐up interviews will be conducted to assess sustained effects of Nature‐VR at 4, 8, 26, and 52 weeks. Discussion The importance and novelty of this study consists of using a first‐of‐its kind, immersive virtual reality technology to target attention and in investigating the health outcomes of the Nature‐VR cognitive intervention among patients with HF. |
| first_indexed | 2024-04-10T21:53:33Z |
| format | Article |
| id | doaj.art-9571c7c271d9499bbb3be71b9836460c |
| institution | Directory Open Access Journal |
| issn | 2352-8737 |
| language | English |
| last_indexed | 2025-02-17T22:37:20Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj.art-9571c7c271d9499bbb3be71b9836460c2024-12-03T12:37:31ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372022-01-0181n/an/a10.1002/trc2.12230Virtual reality cognitive intervention for heart failure: CORE study protocolMiyeon Jung0Liana G. Apostolova1Debra K. Moser2Irmina Gradus‐Pizlo3Sujuan Gao4Jeff L. Rogers5Susan J. Pressler6Indiana University School of Nursing Indianapolis Indiana USAIndiana University School of Medicine, Department of Neurology, Radiology, and Medical and Molecular Genetics Indianapolis Indiana USAUniversity of Kentucky College of Nursing Lexington Kentucky USADepartment of Medicine University of California Irvine School of Medicine Orange California USADepartment of Biostatistics and Health Data Science Indiana University School of Medicine Indianapolis Indiana USAIndiana University UITS Advanced Visualization Lab Indianapolis Indiana USAIndiana University School of Nursing Indianapolis Indiana USAAbstract Introduction Heart failure (HF) is a prevalent, serious chronic illness that affects 6.5 million adults in the United States. Among patients with HF, the prevalence of attention impairment is reported to range from 15% to 27%. Although attention is fundamental to human activities including HF self‐care, cognitive interventions for patients with HF that target improvement in attention are scarce. The COgnitive intervention to Restore attention using nature Environment (CORE) study aims to test the preliminary efficacy of the newly developed Nature‐VR, a virtual reality‐based cognitive intervention that is based on the restorative effects of nature. Nature‐VR development was guided by Attention Restoration Theory. The target outcomes are attention, HF self‐care, and health‐related quality of life (HRQoL). Our exploratory aims examine the associations between attention and several putative/established HF biomarkers (eg, oxygen saturation, brain‐derived neurotrophic factor, apolipoprotein E, dopamine receptor, and dopamine transporter genes) as well as the effect of Nature‐VR on cognitive performance in other domains (ie, global cognition, memory, visuospatial, executive function, and language), cardiac and neurological events, and mortality. Methods This single‐blinded, two‐group randomized‐controlled pilot study will enroll 74 participants with HF. The Nature‐VR intervention group will view three‐dimensional nature pictures using a virtual reality headset for 10 minutes per day, 5 days per week for 4 weeks (a total of 200 minutes). The active comparison group, Urban‐VR, will view three‐dimensional urban pictures using a virtual reality headset to match the Nature‐VR intervention in intervention dose and delivery mode, but not in content. After baseline interviews, four follow‐up interviews will be conducted to assess sustained effects of Nature‐VR at 4, 8, 26, and 52 weeks. Discussion The importance and novelty of this study consists of using a first‐of‐its kind, immersive virtual reality technology to target attention and in investigating the health outcomes of the Nature‐VR cognitive intervention among patients with HF.https://doi.org/10.1002/trc2.12230apolipoprotein Eattentionaugmented realitybiomarkersbrain‐derived neurotrophic factorclinical trial protocol |
| spellingShingle | Miyeon Jung Liana G. Apostolova Debra K. Moser Irmina Gradus‐Pizlo Sujuan Gao Jeff L. Rogers Susan J. Pressler Virtual reality cognitive intervention for heart failure: CORE study protocol Alzheimer’s & Dementia: Translational Research & Clinical Interventions apolipoprotein E attention augmented reality biomarkers brain‐derived neurotrophic factor clinical trial protocol |
| title | Virtual reality cognitive intervention for heart failure: CORE study protocol |
| title_full | Virtual reality cognitive intervention for heart failure: CORE study protocol |
| title_fullStr | Virtual reality cognitive intervention for heart failure: CORE study protocol |
| title_full_unstemmed | Virtual reality cognitive intervention for heart failure: CORE study protocol |
| title_short | Virtual reality cognitive intervention for heart failure: CORE study protocol |
| title_sort | virtual reality cognitive intervention for heart failure core study protocol |
| topic | apolipoprotein E attention augmented reality biomarkers brain‐derived neurotrophic factor clinical trial protocol |
| url | https://doi.org/10.1002/trc2.12230 |
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