Green tea catechin epigallocatechin gallate alleviates high‐fat diet‐induced obesity in mice by regulating the gut–brain axis
Abstract Plant polyphenols have gained attention in recent years because of their potential to alleviate obesity and metabolic syndrome, protect neurological function, and maintain intestinal function. Here, we evaluated the effect of green tea catechin epigallocatechin gallate (EGCG) to suppress ob...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-09-01
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| Series: | Food Frontiers |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/fft2.252 |
| _version_ | 1797671344349904896 |
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| author | Jihong Zhou Lejia Ding Wei Chen Yuefei Wang |
| author_facet | Jihong Zhou Lejia Ding Wei Chen Yuefei Wang |
| author_sort | Jihong Zhou |
| collection | DOAJ |
| description | Abstract Plant polyphenols have gained attention in recent years because of their potential to alleviate obesity and metabolic syndrome, protect neurological function, and maintain intestinal function. Here, we evaluated the effect of green tea catechin epigallocatechin gallate (EGCG) to suppress obesity, alleviate intestinal inflammation, and regulate hypothalamic neurotransmitters in high‐fat diet mice. Obese male C57BL/6J mice were gavaged with 25, 50, or 100 mg/kg·body weight (bw) of EGCG or water per day for 6 weeks. The results demonstrated that EGCG significantly reduced bw, fat accumulation, and liver steatosis. EGCG also modulated hypothalamic neurotransmitters such as dopamine and 5‐HTP. Besides, EGCG attenuated the expression of colonic inflammatory factors and barrier damage, increased the gut microbial abundance such as genus Alloprevotella, reduced short‐chain fatty acids, and downregulated the transcription factors. The results suggest that EGCG may alleviate obesity and related metabolic disorders through gut–brain interaction. |
| first_indexed | 2024-03-11T21:13:59Z |
| format | Article |
| id | doaj.art-9571d15c275d4371bb63537043ed670e |
| institution | Directory Open Access Journal |
| issn | 2643-8429 |
| language | English |
| last_indexed | 2024-03-11T21:13:59Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Frontiers |
| spelling | doaj.art-9571d15c275d4371bb63537043ed670e2023-09-29T05:33:43ZengWileyFood Frontiers2643-84292023-09-01431413142510.1002/fft2.252Green tea catechin epigallocatechin gallate alleviates high‐fat diet‐induced obesity in mice by regulating the gut–brain axisJihong Zhou0Lejia Ding1Wei Chen2Yuefei Wang3Tea Research Institute Zhejiang University Hangzhou P. R. ChinaTea Research Institute Zhejiang University Hangzhou P. R. ChinaTea Research Institute Zhejiang University Hangzhou P. R. ChinaTea Research Institute Zhejiang University Hangzhou P. R. ChinaAbstract Plant polyphenols have gained attention in recent years because of their potential to alleviate obesity and metabolic syndrome, protect neurological function, and maintain intestinal function. Here, we evaluated the effect of green tea catechin epigallocatechin gallate (EGCG) to suppress obesity, alleviate intestinal inflammation, and regulate hypothalamic neurotransmitters in high‐fat diet mice. Obese male C57BL/6J mice were gavaged with 25, 50, or 100 mg/kg·body weight (bw) of EGCG or water per day for 6 weeks. The results demonstrated that EGCG significantly reduced bw, fat accumulation, and liver steatosis. EGCG also modulated hypothalamic neurotransmitters such as dopamine and 5‐HTP. Besides, EGCG attenuated the expression of colonic inflammatory factors and barrier damage, increased the gut microbial abundance such as genus Alloprevotella, reduced short‐chain fatty acids, and downregulated the transcription factors. The results suggest that EGCG may alleviate obesity and related metabolic disorders through gut–brain interaction.https://doi.org/10.1002/fft2.252central nervous systemgut microbiotaneurotransmittersobese miceshort‐chain fatty acidstea polyphenols |
| spellingShingle | Jihong Zhou Lejia Ding Wei Chen Yuefei Wang Green tea catechin epigallocatechin gallate alleviates high‐fat diet‐induced obesity in mice by regulating the gut–brain axis Food Frontiers central nervous system gut microbiota neurotransmitters obese mice short‐chain fatty acids tea polyphenols |
| title | Green tea catechin epigallocatechin gallate alleviates high‐fat diet‐induced obesity in mice by regulating the gut–brain axis |
| title_full | Green tea catechin epigallocatechin gallate alleviates high‐fat diet‐induced obesity in mice by regulating the gut–brain axis |
| title_fullStr | Green tea catechin epigallocatechin gallate alleviates high‐fat diet‐induced obesity in mice by regulating the gut–brain axis |
| title_full_unstemmed | Green tea catechin epigallocatechin gallate alleviates high‐fat diet‐induced obesity in mice by regulating the gut–brain axis |
| title_short | Green tea catechin epigallocatechin gallate alleviates high‐fat diet‐induced obesity in mice by regulating the gut–brain axis |
| title_sort | green tea catechin epigallocatechin gallate alleviates high fat diet induced obesity in mice by regulating the gut brain axis |
| topic | central nervous system gut microbiota neurotransmitters obese mice short‐chain fatty acids tea polyphenols |
| url | https://doi.org/10.1002/fft2.252 |
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