Flash-Like Albuminuria in Acute Kidney Injury Caused by Puumala Hantavirus Infection
Transient proteinuria and acute kidney injury (AKI) are characteristics of Puumala virus (PUUV) infection. Albuminuria peaks around the fifth day and associates with AKI severity. To evaluate albuminuria disappearance rate, we quantified albumin excretion at different time points after the fever ons...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-07-01
|
| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/9/8/615 |
| _version_ | 1797561084303900672 |
|---|---|
| author | Paula Mantula Johanna Tietäväinen Jan Clement Onni Niemelä Ilkka Pörsti Antti Vaheri Jukka Mustonen Satu Mäkelä Tuula Outinen |
| author_facet | Paula Mantula Johanna Tietäväinen Jan Clement Onni Niemelä Ilkka Pörsti Antti Vaheri Jukka Mustonen Satu Mäkelä Tuula Outinen |
| author_sort | Paula Mantula |
| collection | DOAJ |
| description | Transient proteinuria and acute kidney injury (AKI) are characteristics of Puumala virus (PUUV) infection. Albuminuria peaks around the fifth day and associates with AKI severity. To evaluate albuminuria disappearance rate, we quantified albumin excretion at different time points after the fever onset. The study included 141 consecutive patients hospitalized due to acute PUUV infection in Tampere University Hospital, Finland. Timed overnight albumin excretion (cU-Alb) was measured during the acute phase in 133 patients, once or twice during the convalescent phase within three months in 94 patients, and at six months in 36 patients. During hospitalization, 30% of the patients had moderately increased albuminuria (cU-Alb 20–200 μg/min), while 57% presented with severely increased albuminuria (cU-Alb >200 μg/min). Median cU-Alb was 311 μg/min (range 2.2–6460) ≤7 days after fever onset, 235 μg/min (range 6.8–5479) at 8–13 days and 2.8 μg/min (range 0.5–18.2) at 14–20 days. After that, only one of the measurements showed albuminuria (35.4 μg/min at day 44). At six months, the median cU-Alb was 2.0 μg/min (range 0.6–14.5). Albuminuria makes a flash-like appearance in PUUV infection and returns rapidly to normal levels within 2–3 weeks after fever onset. In the case of AKI, this is a unique phenomenon. |
| first_indexed | 2024-03-10T18:09:17Z |
| format | Article |
| id | doaj.art-95720271a3374d6980717082e1c1805b |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T18:09:17Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-95720271a3374d6980717082e1c1805b2023-11-20T08:13:20ZengMDPI AGPathogens2076-08172020-07-019861510.3390/pathogens9080615Flash-Like Albuminuria in Acute Kidney Injury Caused by Puumala Hantavirus InfectionPaula Mantula0Johanna Tietäväinen1Jan Clement2Onni Niemelä3Ilkka Pörsti4Antti Vaheri5Jukka Mustonen6Satu Mäkelä7Tuula Outinen8Department of Internal Medicine, Tampere University Hospital, 33521 Tampere, FinlandDepartment of Internal Medicine, Tampere University Hospital, 33521 Tampere, FinlandDepartment of Microbiology, Immunology and Transplantation, Rega Institute, National Reference Center for Hantaviruses, Laboratory of Clinical and Epidemiological Virology, KU Leuven, 3000 Leuven, BelgiumFaculty of Medicine and Health Technology, Tampere University, 33100 Tampere, FinlandDepartment of Internal Medicine, Tampere University Hospital, 33521 Tampere, FinlandDepartment of Virology, Medicum, University of Helsinki, 00100 Helsinki, FinlandDepartment of Internal Medicine, Tampere University Hospital, 33521 Tampere, FinlandDepartment of Internal Medicine, Tampere University Hospital, 33521 Tampere, FinlandDepartment of Internal Medicine, Tampere University Hospital, 33521 Tampere, FinlandTransient proteinuria and acute kidney injury (AKI) are characteristics of Puumala virus (PUUV) infection. Albuminuria peaks around the fifth day and associates with AKI severity. To evaluate albuminuria disappearance rate, we quantified albumin excretion at different time points after the fever onset. The study included 141 consecutive patients hospitalized due to acute PUUV infection in Tampere University Hospital, Finland. Timed overnight albumin excretion (cU-Alb) was measured during the acute phase in 133 patients, once or twice during the convalescent phase within three months in 94 patients, and at six months in 36 patients. During hospitalization, 30% of the patients had moderately increased albuminuria (cU-Alb 20–200 μg/min), while 57% presented with severely increased albuminuria (cU-Alb >200 μg/min). Median cU-Alb was 311 μg/min (range 2.2–6460) ≤7 days after fever onset, 235 μg/min (range 6.8–5479) at 8–13 days and 2.8 μg/min (range 0.5–18.2) at 14–20 days. After that, only one of the measurements showed albuminuria (35.4 μg/min at day 44). At six months, the median cU-Alb was 2.0 μg/min (range 0.6–14.5). Albuminuria makes a flash-like appearance in PUUV infection and returns rapidly to normal levels within 2–3 weeks after fever onset. In the case of AKI, this is a unique phenomenon.https://www.mdpi.com/2076-0817/9/8/615albuminuriaproteinuriaPuumala virushantavirusacute kidney injuryhemorrhagic fever with renal syndrome |
| spellingShingle | Paula Mantula Johanna Tietäväinen Jan Clement Onni Niemelä Ilkka Pörsti Antti Vaheri Jukka Mustonen Satu Mäkelä Tuula Outinen Flash-Like Albuminuria in Acute Kidney Injury Caused by Puumala Hantavirus Infection Pathogens albuminuria proteinuria Puumala virus hantavirus acute kidney injury hemorrhagic fever with renal syndrome |
| title | Flash-Like Albuminuria in Acute Kidney Injury Caused by Puumala Hantavirus Infection |
| title_full | Flash-Like Albuminuria in Acute Kidney Injury Caused by Puumala Hantavirus Infection |
| title_fullStr | Flash-Like Albuminuria in Acute Kidney Injury Caused by Puumala Hantavirus Infection |
| title_full_unstemmed | Flash-Like Albuminuria in Acute Kidney Injury Caused by Puumala Hantavirus Infection |
| title_short | Flash-Like Albuminuria in Acute Kidney Injury Caused by Puumala Hantavirus Infection |
| title_sort | flash like albuminuria in acute kidney injury caused by puumala hantavirus infection |
| topic | albuminuria proteinuria Puumala virus hantavirus acute kidney injury hemorrhagic fever with renal syndrome |
| url | https://www.mdpi.com/2076-0817/9/8/615 |
| work_keys_str_mv | AT paulamantula flashlikealbuminuriainacutekidneyinjurycausedbypuumalahantavirusinfection AT johannatietavainen flashlikealbuminuriainacutekidneyinjurycausedbypuumalahantavirusinfection AT janclement flashlikealbuminuriainacutekidneyinjurycausedbypuumalahantavirusinfection AT onniniemela flashlikealbuminuriainacutekidneyinjurycausedbypuumalahantavirusinfection AT ilkkaporsti flashlikealbuminuriainacutekidneyinjurycausedbypuumalahantavirusinfection AT anttivaheri flashlikealbuminuriainacutekidneyinjurycausedbypuumalahantavirusinfection AT jukkamustonen flashlikealbuminuriainacutekidneyinjurycausedbypuumalahantavirusinfection AT satumakela flashlikealbuminuriainacutekidneyinjurycausedbypuumalahantavirusinfection AT tuulaoutinen flashlikealbuminuriainacutekidneyinjurycausedbypuumalahantavirusinfection |