Determination of the Cavitation Pressure Threshold in Focused Ultrasound Wave Fields applied to Sonosensitive, Biocompatible Nanoparticles for Drug Delivery Applications
Employing sonosensitive nanoparticles as carriers of active pharmaceutical ingredients emerges in ultrasonic Drug Delivery. Drug release can be initiated by focused ultrasound via the effect of inertial cavitation in certain target areas of particle loaded tissue. For stimulating inertial cavitation...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2020-09-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2020-3138 |
| _version_ | 1811324194484387840 |
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| author | George Benedikt Lehner Markus Fink Michael Rupitsch Stefan J. Ermert Helmut Hiltl Pia T. Savšek Ula Lee Geoffrey |
| author_facet | George Benedikt Lehner Markus Fink Michael Rupitsch Stefan J. Ermert Helmut Hiltl Pia T. Savšek Ula Lee Geoffrey |
| author_sort | George Benedikt |
| collection | DOAJ |
| description | Employing sonosensitive nanoparticles as carriers of active pharmaceutical ingredients emerges in ultrasonic Drug Delivery. Drug release can be initiated by focused ultrasound via the effect of inertial cavitation in certain target areas of particle loaded tissue. For stimulating inertial cavitation, a specific peak rarefaction pressure threshold must be exceeded. This pressure threshold has to be determined in order to estimate the risk of tissue damage during the drug release procedure. Therefore, this study provides a method to reliably verify the cavitation pressure threshold of sonosensitive and biocompatible nanoparticles. |
| first_indexed | 2024-04-13T14:09:56Z |
| format | Article |
| id | doaj.art-9575d0b19ca94602982980cf3156bb02 |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-04-13T14:09:56Z |
| publishDate | 2020-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-9575d0b19ca94602982980cf3156bb022022-12-22T02:43:48ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042020-09-016353954210.1515/cdbme-2020-3138cdbme-2020-3138Determination of the Cavitation Pressure Threshold in Focused Ultrasound Wave Fields applied to Sonosensitive, Biocompatible Nanoparticles for Drug Delivery ApplicationsGeorge Benedikt0Lehner Markus1Fink Michael2Rupitsch Stefan J.3Ermert Helmut4Hiltl Pia T.5Savšek Ula6Lee Geoffrey7Department of Sensor Technology, Paul-Gordan-Street 3/5,Erlangen, GermanyDepartment of Sensor Technology, Paul-Gordan-Street 3/5,Erlangen, GermanyDepartment of Sensor Technology, Paul-Gordan-Street 3/5,Erlangen, GermanyDepartment of Sensor Technology, Paul-Gordan-Street 3/5,Erlangen, GermanyDepartment of Sensor Technology, Paul-Gordan-Street 3/5,Erlangen, GermanyDepartment of Pharmaceutics, Cauerstraße 4,Erlangen, GermanyDepartment of Pharmaceutics, Cauerstraße 4,Erlangen, GermanyDepartment of Pharmaceutics, Cauerstraße 4,Erlangen, GermanyEmploying sonosensitive nanoparticles as carriers of active pharmaceutical ingredients emerges in ultrasonic Drug Delivery. Drug release can be initiated by focused ultrasound via the effect of inertial cavitation in certain target areas of particle loaded tissue. For stimulating inertial cavitation, a specific peak rarefaction pressure threshold must be exceeded. This pressure threshold has to be determined in order to estimate the risk of tissue damage during the drug release procedure. Therefore, this study provides a method to reliably verify the cavitation pressure threshold of sonosensitive and biocompatible nanoparticles.https://doi.org/10.1515/cdbme-2020-3138drug deliveryfuscavitation pressure thresholdnanoparticles |
| spellingShingle | George Benedikt Lehner Markus Fink Michael Rupitsch Stefan J. Ermert Helmut Hiltl Pia T. Savšek Ula Lee Geoffrey Determination of the Cavitation Pressure Threshold in Focused Ultrasound Wave Fields applied to Sonosensitive, Biocompatible Nanoparticles for Drug Delivery Applications Current Directions in Biomedical Engineering drug delivery fus cavitation pressure threshold nanoparticles |
| title | Determination of the Cavitation Pressure Threshold in Focused Ultrasound Wave Fields applied to Sonosensitive, Biocompatible Nanoparticles for Drug Delivery Applications |
| title_full | Determination of the Cavitation Pressure Threshold in Focused Ultrasound Wave Fields applied to Sonosensitive, Biocompatible Nanoparticles for Drug Delivery Applications |
| title_fullStr | Determination of the Cavitation Pressure Threshold in Focused Ultrasound Wave Fields applied to Sonosensitive, Biocompatible Nanoparticles for Drug Delivery Applications |
| title_full_unstemmed | Determination of the Cavitation Pressure Threshold in Focused Ultrasound Wave Fields applied to Sonosensitive, Biocompatible Nanoparticles for Drug Delivery Applications |
| title_short | Determination of the Cavitation Pressure Threshold in Focused Ultrasound Wave Fields applied to Sonosensitive, Biocompatible Nanoparticles for Drug Delivery Applications |
| title_sort | determination of the cavitation pressure threshold in focused ultrasound wave fields applied to sonosensitive biocompatible nanoparticles for drug delivery applications |
| topic | drug delivery fus cavitation pressure threshold nanoparticles |
| url | https://doi.org/10.1515/cdbme-2020-3138 |
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