The application of Gaussian mixture models for signal quantification in MALDI-TOF mass spectrometry of peptides.

The application of Gaussian mixture models for signal quantification in MALDI-TOF mass spectrometry of peptides.

Matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF) coupled with stable isotope standards (SIS) has been used to quantify native peptides. This peptide quantification by MALDI-TOF approach has difficulties quantifying samples containing peptides with ion currents in overlapping sp...

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Bibliographic Details
Main Authors: John Christian G Spainhour, Michael G Janech, John H Schwacke, Juan Carlos Q Velez, Viswanathan Ramakrishnan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4221630?pdf=render

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