Fast Ca2+ Transients of Inner Hair Cells Arise Coupled and Uncoupled to Ca2+ Waves of Inner Supporting Cells in the Developing Mouse Cochlea

Fast Ca2+ Transients of Inner Hair Cells Arise Coupled and Uncoupled to Ca2+ Waves of Inner Supporting Cells in the Developing Mouse Cochlea

Before the onset of hearing, which occurs around postnatal day 12 (P12) in mice, inner hair cells (IHCs) of the immature cochlea generate sound-independent Ca2+ action potentials (APs), which stimulate the auditory pathway and guide maturation of neuronal circuits. During these early postnatal days,...

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Bibliographic Details
Main Authors: Tobias Eckrich, Kerstin Blum, Ivan Milenkovic, Jutta Engel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cochlea
spontaneous activity
development
Ca2+ wave
inner hair cell
CaV1.3
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00264/full

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