Unexpected Pro-Fibrotic Effect of MIF in Non-Alcoholic Steatohepatitis Is Linked to a Shift in NKT Cell Populations

Unexpected Pro-Fibrotic Effect of MIF in Non-Alcoholic Steatohepatitis Is Linked to a Shift in NKT Cell Populations

Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory cytokine with anti-fibrotic properties in toxic liver injury models and anti-steatotic functions in non-alcoholic fatty liver disease (NAFLD) attributed to the CD74/AMPK signaling pathway. As NAFLD progression is associated w...

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Bibliographic Details
Main Authors: Daniel Heinrichs, Elisa F. Brandt, Petra Fischer, Janine Köhncke, Theresa H. Wirtz, Nurdan Guldiken, Sonja Djudjaj, Peter Boor, Daniela Kroy, Ralf Weiskirchen, Richard Bucala, Hermann E. Wasmuth, Pavel Strnad, Christian Trautwein, Jürgen Bernhagen, Marie-Luise Berres
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
MIF
NKT cells
NASH
liver fibrosis
Online Access:https://www.mdpi.com/2073-4409/10/2/252

Internet

https://www.mdpi.com/2073-4409/10/2/252

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