Type 2 Deiodinase Thr92Ala Polymorphism Is Not Associated with Cognitive Impairment in Older Adults: A Cross-Sectional Study
Background: Type 2 Deiodinase (DIO2) converts thyroxine (T4) into the active hormone triiodothyronine (T3). Thr92Ala DIO2 polymorphism has been associated with reduced conversion of T4 into T3 and central nervous system hypothyroidism. However, how Thr92Ala DIO2 polymorphism affects cognitive functi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/5/375 |
| _version_ | 1797497998031192064 |
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| author | Wallace Klein Schwengber Vitor Bock Silveira Guilherme Moreira Hetzel Amanda Robaina Lucieli Ceolin Marli Teresinha Camelier Iuri Goemann Roberta Rigo Dalla Corte Rafael Selbach Scheffel Renato Gorga Bandeira de Mello Ana Luiza Maia José Miguel Dora |
| author_facet | Wallace Klein Schwengber Vitor Bock Silveira Guilherme Moreira Hetzel Amanda Robaina Lucieli Ceolin Marli Teresinha Camelier Iuri Goemann Roberta Rigo Dalla Corte Rafael Selbach Scheffel Renato Gorga Bandeira de Mello Ana Luiza Maia José Miguel Dora |
| author_sort | Wallace Klein Schwengber |
| collection | DOAJ |
| description | Background: Type 2 Deiodinase (DIO2) converts thyroxine (T4) into the active hormone triiodothyronine (T3). Thr92Ala DIO2 polymorphism has been associated with reduced conversion of T4 into T3 and central nervous system hypothyroidism. However, how Thr92Ala DIO2 polymorphism affects cognitive function is still unclear. Objective: To assess the association between Thr92Ala DIO2 polymorphism and cognitive performance in older adults. Design: Cross-sectional study. Setting: University-based tertiary hospital in Brazil. Patients: > 65-year-old with no limiting clinical disease. Interventions: All participants answered a standard questionnaire before undergoing thyroid function laboratory evaluation and genotyping of the Thr92Ala DIO2 polymorphism. Main Outcomes: Cognitive impairment measured by the Word List Memory task from the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Battery (CERAD-NB) and the Brief Cognitive Screening Battery (BCSB). Results: A hundred individuals were included. Clinical and laboratory characteristics were similar among DIO2 genotypes (all <i>p</i> > 0.05). No differences were found in the Word List Memory, recall, or recognition tests of the CERAD-NB assuming a recessive model for the Ala/Ala vs. Thr/Ala-Thr/Thr genotypes. Results of Clock Drawing Test, Animal Fluency Test, Mini-Mental State Exam, and Figure Memory Test of the BCSB were similar between groups. Conclusions: These findings suggest that Thr92Ala DIO2 polymorphism is not associated with relevant cognitive impairment in older adults. |
| first_indexed | 2024-03-10T03:27:09Z |
| format | Article |
| id | doaj.art-9578a90941f34ceab36f668881b8defe |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T03:27:09Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-9578a90941f34ceab36f668881b8defe2023-11-23T12:06:29ZengMDPI AGMetabolites2218-19892022-04-0112537510.3390/metabo12050375Type 2 Deiodinase Thr92Ala Polymorphism Is Not Associated with Cognitive Impairment in Older Adults: A Cross-Sectional StudyWallace Klein Schwengber0Vitor Bock Silveira1Guilherme Moreira Hetzel2Amanda Robaina3Lucieli Ceolin4Marli Teresinha Camelier5Iuri Goemann6Roberta Rigo Dalla Corte7Rafael Selbach Scheffel8Renato Gorga Bandeira de Mello9Ana Luiza Maia10José Miguel Dora11Thyroid Unit, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, BrazilThyroid Unit, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, BrazilThyroid Unit, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, BrazilThyroid Unit, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, BrazilThyroid Unit, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, BrazilThyroid Unit, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, BrazilThyroid Unit, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, BrazilGeriatric Unit, Internal Medicine Division, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, BrazilThyroid Unit, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, BrazilGeriatric Unit, Internal Medicine Division, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, BrazilThyroid Unit, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, BrazilThyroid Unit, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, BrazilBackground: Type 2 Deiodinase (DIO2) converts thyroxine (T4) into the active hormone triiodothyronine (T3). Thr92Ala DIO2 polymorphism has been associated with reduced conversion of T4 into T3 and central nervous system hypothyroidism. However, how Thr92Ala DIO2 polymorphism affects cognitive function is still unclear. Objective: To assess the association between Thr92Ala DIO2 polymorphism and cognitive performance in older adults. Design: Cross-sectional study. Setting: University-based tertiary hospital in Brazil. Patients: > 65-year-old with no limiting clinical disease. Interventions: All participants answered a standard questionnaire before undergoing thyroid function laboratory evaluation and genotyping of the Thr92Ala DIO2 polymorphism. Main Outcomes: Cognitive impairment measured by the Word List Memory task from the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Battery (CERAD-NB) and the Brief Cognitive Screening Battery (BCSB). Results: A hundred individuals were included. Clinical and laboratory characteristics were similar among DIO2 genotypes (all <i>p</i> > 0.05). No differences were found in the Word List Memory, recall, or recognition tests of the CERAD-NB assuming a recessive model for the Ala/Ala vs. Thr/Ala-Thr/Thr genotypes. Results of Clock Drawing Test, Animal Fluency Test, Mini-Mental State Exam, and Figure Memory Test of the BCSB were similar between groups. Conclusions: These findings suggest that Thr92Ala DIO2 polymorphism is not associated with relevant cognitive impairment in older adults.https://www.mdpi.com/2218-1989/12/5/375Type 2 deiodinaseDIO2 Thr92Ala polymorphismiodothyronine deiodinase Type IIThr92Ala polymorphismcognitionolder adults |
| spellingShingle | Wallace Klein Schwengber Vitor Bock Silveira Guilherme Moreira Hetzel Amanda Robaina Lucieli Ceolin Marli Teresinha Camelier Iuri Goemann Roberta Rigo Dalla Corte Rafael Selbach Scheffel Renato Gorga Bandeira de Mello Ana Luiza Maia José Miguel Dora Type 2 Deiodinase Thr92Ala Polymorphism Is Not Associated with Cognitive Impairment in Older Adults: A Cross-Sectional Study Metabolites Type 2 deiodinase DIO2 Thr92Ala polymorphism iodothyronine deiodinase Type II Thr92Ala polymorphism cognition older adults |
| title | Type 2 Deiodinase Thr92Ala Polymorphism Is Not Associated with Cognitive Impairment in Older Adults: A Cross-Sectional Study |
| title_full | Type 2 Deiodinase Thr92Ala Polymorphism Is Not Associated with Cognitive Impairment in Older Adults: A Cross-Sectional Study |
| title_fullStr | Type 2 Deiodinase Thr92Ala Polymorphism Is Not Associated with Cognitive Impairment in Older Adults: A Cross-Sectional Study |
| title_full_unstemmed | Type 2 Deiodinase Thr92Ala Polymorphism Is Not Associated with Cognitive Impairment in Older Adults: A Cross-Sectional Study |
| title_short | Type 2 Deiodinase Thr92Ala Polymorphism Is Not Associated with Cognitive Impairment in Older Adults: A Cross-Sectional Study |
| title_sort | type 2 deiodinase thr92ala polymorphism is not associated with cognitive impairment in older adults a cross sectional study |
| topic | Type 2 deiodinase DIO2 Thr92Ala polymorphism iodothyronine deiodinase Type II Thr92Ala polymorphism cognition older adults |
| url | https://www.mdpi.com/2218-1989/12/5/375 |
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