Sex differences in the percentage of IRF5 positive B cells are associated with higher production of TNF-α in women in response to TLR9 in humans

Sex differences in the percentage of IRF5 positive B cells are associated with higher production of TNF-α in women in response to TLR9 in humans

Highlights Women showed higher percentage of IRF5 positive B cells compared to men. After stimulation with a TLR7 or TLR9 agonist, women showed higher percentages of IRF5 positive B cells compared with those of men. B cells of women produced higher levels of TNF-α in response to TLR9 stimulation. IR...

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Bibliographic Details
Main Authors: Claudia Beisel, Ana Jordan-Paiz, Sandra Köllmann, Annika Elise Ahrenstorf, Benedetta Padoan, Tanja Barkhausen, Marylyn M. Addo, Marcus Altfeld
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Biology of Sex Differences
Subjects:
B cells
Interferon regulatory factor 5
Sex differences
Toll-like receptor 7/9
Tumor necrosis factor-α
Online Access:https://doi.org/10.1186/s13293-023-00495-x

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