Cytogenetic and Genetic Abnormalities with Diagnostic Value in Myelodysplastic Syndromes (MDS): Focus on the Pre-Messenger RNA Splicing Process

Cytogenetic and Genetic Abnormalities with Diagnostic Value in Myelodysplastic Syndromes (MDS): Focus on the Pre-Messenger RNA Splicing Process

Myelodysplastic syndromes (MDS) are considered to be diseases associated with splicing defects. A large number of genes involved in the pre-messenger RNA splicing process are mutated in MDS. Deletion of 5q and 7q are of diagnostic value, and those chromosome regions bear the numbers of splicing gene...

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Bibliographic Details
Main Authors: Nathalie Douet-Guilbert, Benoît Soubise, Delphine G. Bernard, Marie-Bérengère Troadec
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Diagnostics
Subjects:
myelodysplasia
splicing
diagnosis
del(5q)
chromosome abnormalities
SF3B1
Online Access:https://www.mdpi.com/2075-4418/12/7/1658

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