β-Cell Autoantibodies and Their Function in Taiwanese Children With Type 1 Diabetes Mellitus
To understand the importance of autoimmunity in the development of type 1 diabetes in Taiwanese children, we evaluated the presence of β-cell autoantibodies and their correlation with residual β-cell function. Methods: From 1989 to 2006, 157 Taiwanese children with newly diagnosed type 1 diabetes we...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2009-11-01
|
| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664609604174 |
| _version_ | 1811201416044216320 |
|---|---|
| author | Yi-Ching Tung Mei-Huei Chen Cheng-Ting Lee Wen-Yu Tsai |
| author_facet | Yi-Ching Tung Mei-Huei Chen Cheng-Ting Lee Wen-Yu Tsai |
| author_sort | Yi-Ching Tung |
| collection | DOAJ |
| description | To understand the importance of autoimmunity in the development of type 1 diabetes in Taiwanese children, we evaluated the presence of β-cell autoantibodies and their correlation with residual β-cell function.
Methods: From 1989 to 2006, 157 Taiwanese children with newly diagnosed type 1 diabetes were enrolled in this study. We determined the presence of β-cell autoantibodies, such as glutamic acid decarboxylase autoantibodies (GADAs), insulinoma antigen 2 autoantibodies (IA-2As), and insulin autoantibodies (IAAs). A 6-minute glucagon test was also performed at diagnosis.
Results: At diagnosis, 73% of children tested positive for GADAs, 76% for IA-2As and 21% for IAAs. Ninety-two percent of them had at least one of the β-cell autoantibodies detected. Positivity for IAAs was more frequent in patients younger than 5 years than in those older than 5 years (45% vs. 13%). Using multiple regression analysis, the presence of GADAs or IAAs, or age of onset of these patients was an independent factor for residual β-cell function. Younger patients and those with GADAs had less residual β-cell function at disease onset, whereas those with IAAs had more insulin reserve.
Conclusion: Autoimmunity plays an important role in the pathogenesis of type 1 diabetes in Taiwanese children, and the presence of IAAs tends to be more common in younger children. |
| first_indexed | 2024-04-12T02:20:09Z |
| format | Article |
| id | doaj.art-957efa456db249e8bf2a2b3863849e67 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-04-12T02:20:09Z |
| publishDate | 2009-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-957efa456db249e8bf2a2b3863849e672022-12-22T03:52:08ZengElsevierJournal of the Formosan Medical Association0929-66462009-11-011081185686110.1016/S0929-6646(09)60417-4β-Cell Autoantibodies and Their Function in Taiwanese Children With Type 1 Diabetes MellitusYi-Ching Tung0Mei-Huei Chen1Cheng-Ting Lee2Wen-Yu Tsai3Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, Yung Ho Branch of Cardinal Tien Hospital, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, TaiwanTo understand the importance of autoimmunity in the development of type 1 diabetes in Taiwanese children, we evaluated the presence of β-cell autoantibodies and their correlation with residual β-cell function. Methods: From 1989 to 2006, 157 Taiwanese children with newly diagnosed type 1 diabetes were enrolled in this study. We determined the presence of β-cell autoantibodies, such as glutamic acid decarboxylase autoantibodies (GADAs), insulinoma antigen 2 autoantibodies (IA-2As), and insulin autoantibodies (IAAs). A 6-minute glucagon test was also performed at diagnosis. Results: At diagnosis, 73% of children tested positive for GADAs, 76% for IA-2As and 21% for IAAs. Ninety-two percent of them had at least one of the β-cell autoantibodies detected. Positivity for IAAs was more frequent in patients younger than 5 years than in those older than 5 years (45% vs. 13%). Using multiple regression analysis, the presence of GADAs or IAAs, or age of onset of these patients was an independent factor for residual β-cell function. Younger patients and those with GADAs had less residual β-cell function at disease onset, whereas those with IAAs had more insulin reserve. Conclusion: Autoimmunity plays an important role in the pathogenesis of type 1 diabetes in Taiwanese children, and the presence of IAAs tends to be more common in younger children.http://www.sciencedirect.com/science/article/pii/S0929664609604174autoantibodiesC-peptideglucagon testtype 1 diabetes mellitus |
| spellingShingle | Yi-Ching Tung Mei-Huei Chen Cheng-Ting Lee Wen-Yu Tsai β-Cell Autoantibodies and Their Function in Taiwanese Children With Type 1 Diabetes Mellitus Journal of the Formosan Medical Association autoantibodies C-peptide glucagon test type 1 diabetes mellitus |
| title | β-Cell Autoantibodies and Their Function in Taiwanese Children With Type 1 Diabetes Mellitus |
| title_full | β-Cell Autoantibodies and Their Function in Taiwanese Children With Type 1 Diabetes Mellitus |
| title_fullStr | β-Cell Autoantibodies and Their Function in Taiwanese Children With Type 1 Diabetes Mellitus |
| title_full_unstemmed | β-Cell Autoantibodies and Their Function in Taiwanese Children With Type 1 Diabetes Mellitus |
| title_short | β-Cell Autoantibodies and Their Function in Taiwanese Children With Type 1 Diabetes Mellitus |
| title_sort | β cell autoantibodies and their function in taiwanese children with type 1 diabetes mellitus |
| topic | autoantibodies C-peptide glucagon test type 1 diabetes mellitus |
| url | http://www.sciencedirect.com/science/article/pii/S0929664609604174 |
| work_keys_str_mv | AT yichingtung bcellautoantibodiesandtheirfunctionintaiwanesechildrenwithtype1diabetesmellitus AT meihueichen bcellautoantibodiesandtheirfunctionintaiwanesechildrenwithtype1diabetesmellitus AT chengtinglee bcellautoantibodiesandtheirfunctionintaiwanesechildrenwithtype1diabetesmellitus AT wenyutsai bcellautoantibodiesandtheirfunctionintaiwanesechildrenwithtype1diabetesmellitus |