Comparison of Gut Viral Communities in Atopic Dermatitis and Healthy Children
The immune development and regulation of living individuals are affected by the gut microbiota. The imbalance of gut microbiota is considered to be a key factor that easily induces immune dysregulation and the development of atopic diseases. Atopic dermatitis (AD) is a chronic inflammatory skin dise...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.835467/full |
| _version_ | 1819277100837765120 |
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| author | Xiang Lu Xiang Lu Hao Wang Jingqi Zhang Kexin Jin Ling Ma Yan Wang Shixing Yang Xiaochun Wang Quan Shen Tianji Zhou Hui Xu Wen Zhang |
| author_facet | Xiang Lu Xiang Lu Hao Wang Jingqi Zhang Kexin Jin Ling Ma Yan Wang Shixing Yang Xiaochun Wang Quan Shen Tianji Zhou Hui Xu Wen Zhang |
| author_sort | Xiang Lu |
| collection | DOAJ |
| description | The immune development and regulation of living individuals are affected by the gut microbiota. The imbalance of gut microbiota is considered to be a key factor that easily induces immune dysregulation and the development of atopic diseases. Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects nearly 20% of children. To date, metagenomics research on AD has mainly focused on the skin and gut microbiome. However, here we assessed the composition of the virome in the gut of AD patients and healthy controls for the first time. This study has obtained possible dominant viruses at different viral classification levels. In terms of diversity, the alpha diversity of the patients group was significantly lower than that of the healthy controls group, and the beta diversity of the two groups was significantly different from phylum to family level. These findings provide a new perspective for us to better understand the effect of the gut microecological environment on AD. |
| first_indexed | 2024-12-23T23:50:45Z |
| format | Article |
| id | doaj.art-95850b0af2b4471ba52ddb80376786ed |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-23T23:50:45Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-95850b0af2b4471ba52ddb80376786ed2022-12-21T17:25:24ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-02-01910.3389/fmed.2022.835467835467Comparison of Gut Viral Communities in Atopic Dermatitis and Healthy ChildrenXiang Lu0Xiang Lu1Hao Wang2Jingqi Zhang3Kexin Jin4Ling Ma5Yan Wang6Shixing Yang7Xiaochun Wang8Quan Shen9Tianji Zhou10Hui Xu11Wen Zhang12Department of Dermatology, The Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, ChinaDepartment of Clinical Laboratory, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, ChinaDepartment of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, ChinaSchool of Mathematical Sciences, Soochow University, Suzhou, ChinaDepartment of Dermatology, The Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, ChinaDepartment of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, ChinaDepartment of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, ChinaDepartment of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, ChinaDepartment of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, ChinaDepartment of Dermatology, The Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, ChinaThe immune development and regulation of living individuals are affected by the gut microbiota. The imbalance of gut microbiota is considered to be a key factor that easily induces immune dysregulation and the development of atopic diseases. Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects nearly 20% of children. To date, metagenomics research on AD has mainly focused on the skin and gut microbiome. However, here we assessed the composition of the virome in the gut of AD patients and healthy controls for the first time. This study has obtained possible dominant viruses at different viral classification levels. In terms of diversity, the alpha diversity of the patients group was significantly lower than that of the healthy controls group, and the beta diversity of the two groups was significantly different from phylum to family level. These findings provide a new perspective for us to better understand the effect of the gut microecological environment on AD.https://www.frontiersin.org/articles/10.3389/fmed.2022.835467/fullatopic dermatitisviromegutmetagenomicsdiversity |
| spellingShingle | Xiang Lu Xiang Lu Hao Wang Jingqi Zhang Kexin Jin Ling Ma Yan Wang Shixing Yang Xiaochun Wang Quan Shen Tianji Zhou Hui Xu Wen Zhang Comparison of Gut Viral Communities in Atopic Dermatitis and Healthy Children Frontiers in Medicine atopic dermatitis virome gut metagenomics diversity |
| title | Comparison of Gut Viral Communities in Atopic Dermatitis and Healthy Children |
| title_full | Comparison of Gut Viral Communities in Atopic Dermatitis and Healthy Children |
| title_fullStr | Comparison of Gut Viral Communities in Atopic Dermatitis and Healthy Children |
| title_full_unstemmed | Comparison of Gut Viral Communities in Atopic Dermatitis and Healthy Children |
| title_short | Comparison of Gut Viral Communities in Atopic Dermatitis and Healthy Children |
| title_sort | comparison of gut viral communities in atopic dermatitis and healthy children |
| topic | atopic dermatitis virome gut metagenomics diversity |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.835467/full |
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