Sustained effect of habitual feeding time on daily rhythm of core body temperature in mice
Background and aimCircadian clocks in most peripheral tissues are entrained mainly by feeding. Therefore, this study aimed to investigate whether the daily rhythm of core body temperature (CBT), including the effect of diet-induced thermogenesis, varies according to habitual feeding time.MethodsWild...
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.966788/full |
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| author | Hitoshi Ando Naoto Nagata Takashi Hosono Nazmul Hasan Jun-ichi Morishige Takiko Daikoku Yoshiko Maida Masanori Ono Tomoko Fujiwara Hiroshi Fujiwara |
| author_facet | Hitoshi Ando Naoto Nagata Takashi Hosono Nazmul Hasan Jun-ichi Morishige Takiko Daikoku Yoshiko Maida Masanori Ono Tomoko Fujiwara Hiroshi Fujiwara |
| author_sort | Hitoshi Ando |
| collection | DOAJ |
| description | Background and aimCircadian clocks in most peripheral tissues are entrained mainly by feeding. Therefore, this study aimed to investigate whether the daily rhythm of core body temperature (CBT), including the effect of diet-induced thermogenesis, varies according to habitual feeding time.MethodsWild-type and uncoupling protein 1 (UCP1) knockout mice were fed only during the first 4 h (Breakfast group) or the last 4 h of the dark period (Dinner group) for 17 days. On day 18, both groups were fed twice for 2 h, at the same starting times. Locomotor activity and CBT were measured continuously during the experiment.ResultsOn day 18, CBT increased at the beginning of each feeding period, regardless of the group and strain. However, the CBT increase induced by the first meal decreased sharply in the Breakfast group and mildly in the Dinner group; the opposite was observed after the second meal. In UCP1 knockout, but not wild-type, mice, the total amount of CBT was significantly lower in the Dinner group than in the Breakfast group. These effects were mostly independent of the locomotor activity and food intake.ConclusionThese results reveal that the effect of habitual feeding time on the daily rhythm of CBT is sustained at least until the following day. These effects may be mediated by both UCP1-dependent and -independent mechanisms. |
| first_indexed | 2024-04-13T18:48:23Z |
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| id | doaj.art-9585b97199d849c1a4f4ddf394025f36 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-13T18:48:23Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-9585b97199d849c1a4f4ddf394025f362022-12-22T02:34:31ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-08-01910.3389/fnut.2022.966788966788Sustained effect of habitual feeding time on daily rhythm of core body temperature in miceHitoshi Ando0Naoto Nagata1Takashi Hosono2Nazmul Hasan3Jun-ichi Morishige4Takiko Daikoku5Yoshiko Maida6Masanori Ono7Tomoko Fujiwara8Hiroshi Fujiwara9Department of Cellular and Molecular Function Analysis, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, JapanDepartment of Cellular and Molecular Function Analysis, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, JapanDepartment of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, JapanDepartment of Cellular and Molecular Function Analysis, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, JapanDepartment of Cellular and Molecular Function Analysis, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, JapanDivision of Animal Disease Model, Research Center for Experimental Modeling of Human Disease, Kanazawa University, Kanazawa, JapanFaculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, JapanDepartment of Obstetrics and Gynecology, Tokyo Medical University, Tokyo, JapanDepartment of Human Life Environments, Kyoto Notre Dame University, Kyoto, JapanDepartment of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, JapanBackground and aimCircadian clocks in most peripheral tissues are entrained mainly by feeding. Therefore, this study aimed to investigate whether the daily rhythm of core body temperature (CBT), including the effect of diet-induced thermogenesis, varies according to habitual feeding time.MethodsWild-type and uncoupling protein 1 (UCP1) knockout mice were fed only during the first 4 h (Breakfast group) or the last 4 h of the dark period (Dinner group) for 17 days. On day 18, both groups were fed twice for 2 h, at the same starting times. Locomotor activity and CBT were measured continuously during the experiment.ResultsOn day 18, CBT increased at the beginning of each feeding period, regardless of the group and strain. However, the CBT increase induced by the first meal decreased sharply in the Breakfast group and mildly in the Dinner group; the opposite was observed after the second meal. In UCP1 knockout, but not wild-type, mice, the total amount of CBT was significantly lower in the Dinner group than in the Breakfast group. These effects were mostly independent of the locomotor activity and food intake.ConclusionThese results reveal that the effect of habitual feeding time on the daily rhythm of CBT is sustained at least until the following day. These effects may be mediated by both UCP1-dependent and -independent mechanisms.https://www.frontiersin.org/articles/10.3389/fnut.2022.966788/fullcore body temperature (CBT)diet-induced thermogenesis (DIT)circadian rhythmmeal timingskipping breakfast |
| spellingShingle | Hitoshi Ando Naoto Nagata Takashi Hosono Nazmul Hasan Jun-ichi Morishige Takiko Daikoku Yoshiko Maida Masanori Ono Tomoko Fujiwara Hiroshi Fujiwara Sustained effect of habitual feeding time on daily rhythm of core body temperature in mice Frontiers in Nutrition core body temperature (CBT) diet-induced thermogenesis (DIT) circadian rhythm meal timing skipping breakfast |
| title | Sustained effect of habitual feeding time on daily rhythm of core body temperature in mice |
| title_full | Sustained effect of habitual feeding time on daily rhythm of core body temperature in mice |
| title_fullStr | Sustained effect of habitual feeding time on daily rhythm of core body temperature in mice |
| title_full_unstemmed | Sustained effect of habitual feeding time on daily rhythm of core body temperature in mice |
| title_short | Sustained effect of habitual feeding time on daily rhythm of core body temperature in mice |
| title_sort | sustained effect of habitual feeding time on daily rhythm of core body temperature in mice |
| topic | core body temperature (CBT) diet-induced thermogenesis (DIT) circadian rhythm meal timing skipping breakfast |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.966788/full |
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