MRI Analysis: Optimization of parameters for diffusion MRI to enhance hippocampal subfield analysis and segmentation (Preliminary Data)
Introduction The hippocampus is an important, complex limbic structure anatomically embedded in the medial temporal lobe of each cerebral cortex, which has been implicated in the pathogenesis of neuro-inflammatory disease conditions. Few studies have focused on the characterization of the MRI neuro...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822016376/type/journal_article |
| _version_ | 1797617013341814784 |
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| author | P. Nwaubani A. Colasanti M. Cercignani A. Warner |
| author_facet | P. Nwaubani A. Colasanti M. Cercignani A. Warner |
| author_sort | P. Nwaubani |
| collection | DOAJ |
| description |
Introduction
The hippocampus is an important, complex limbic structure anatomically embedded in the medial temporal lobe of each cerebral cortex, which has been implicated in the pathogenesis of neuro-inflammatory disease conditions. Few studies have focused on the characterization of the MRI neuroimaging signatures of highly physio- pathologically relevant subfields of the hippocampus (CA1, CA4-DG, CA2/CA3, SLRM).
Objectives
Using self-guided manually segmented, Diffusion weighted and NODDI maps created from data obtained from the Human Connectome Project (HCP) we intend to test whether Diffusion MRI-based quantitative imaging parameters (MD, FA, ODI, ISOVF, ICVF), indicative of microstructural characteristics of major hippocampal subfields (CA1, CA2/CA3, CA4-DG and SLRM), correspond to predictions for animal literature and imaging-histology correlations. We will also explore the correlations between these parameters and age.
Methods
We used images from the Public connectome data (updated April 2018), exploring subjects with the 3T MRI sessions obtainable from the WU-Minn HCP Data section. For the purpose of this study, we selected and downloaded 10 preliminary imaging data (6 females and 4 males) based on age variability in the following ranges (26-30, 31-35 and 36+). We manually segmented, and computed quantitative parameters.
Results
Converging and consistent literature allude to decreasing volumes with increasing age. Analyzing the volumes from the diffusion maps (pilot data), this was also the case, with volumes computed from CA1 and DG-CA4 sub regions. IQT also allowed for better appreciation of neuroanatomical boundaries and land marks, hence allowing more regions to be easily manually segmented (addition of CA2/CA3).
Conclusions
Application to Neuroinflammatory imaging data.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:49:28Z |
| format | Article |
| id | doaj.art-958654e9bf8f447f95279401c3fc0635 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:49:28Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-958654e9bf8f447f95279401c3fc06352023-11-17T05:07:04ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S638S63810.1192/j.eurpsy.2022.1637MRI Analysis: Optimization of parameters for diffusion MRI to enhance hippocampal subfield analysis and segmentation (Preliminary Data)P. Nwaubani0A. Colasanti1M. Cercignani2A. Warner3Brighton and Sussex Medical School (BSMS), Clinical Neuroimaging And Neuroscience, Brighton, East Sussex, United KingdomBrighton and Sussex Medical School (BSMS), Clinical Neuroimaging And Neuroscience, Brighton, East Sussex, United KingdomBrighton and Sussex Medical School (BSMS), Clinical Neuroimaging And Neuroscience, Brighton, East Sussex, United KingdomBrighton and Sussex Medical School (BSMS), Clinical Neuroimaging And Neuroscience, Brighton, East Sussex, United Kingdom Introduction The hippocampus is an important, complex limbic structure anatomically embedded in the medial temporal lobe of each cerebral cortex, which has been implicated in the pathogenesis of neuro-inflammatory disease conditions. Few studies have focused on the characterization of the MRI neuroimaging signatures of highly physio- pathologically relevant subfields of the hippocampus (CA1, CA4-DG, CA2/CA3, SLRM). Objectives Using self-guided manually segmented, Diffusion weighted and NODDI maps created from data obtained from the Human Connectome Project (HCP) we intend to test whether Diffusion MRI-based quantitative imaging parameters (MD, FA, ODI, ISOVF, ICVF), indicative of microstructural characteristics of major hippocampal subfields (CA1, CA2/CA3, CA4-DG and SLRM), correspond to predictions for animal literature and imaging-histology correlations. We will also explore the correlations between these parameters and age. Methods We used images from the Public connectome data (updated April 2018), exploring subjects with the 3T MRI sessions obtainable from the WU-Minn HCP Data section. For the purpose of this study, we selected and downloaded 10 preliminary imaging data (6 females and 4 males) based on age variability in the following ranges (26-30, 31-35 and 36+). We manually segmented, and computed quantitative parameters. Results Converging and consistent literature allude to decreasing volumes with increasing age. Analyzing the volumes from the diffusion maps (pilot data), this was also the case, with volumes computed from CA1 and DG-CA4 sub regions. IQT also allowed for better appreciation of neuroanatomical boundaries and land marks, hence allowing more regions to be easily manually segmented (addition of CA2/CA3). Conclusions Application to Neuroinflammatory imaging data. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822016376/type/journal_articleHippocampusNeuroimagingIQTNeuroscience |
| spellingShingle | P. Nwaubani A. Colasanti M. Cercignani A. Warner MRI Analysis: Optimization of parameters for diffusion MRI to enhance hippocampal subfield analysis and segmentation (Preliminary Data) European Psychiatry Hippocampus Neuroimaging IQT Neuroscience |
| title | MRI Analysis: Optimization of parameters for diffusion MRI to enhance hippocampal subfield analysis and segmentation (Preliminary Data) |
| title_full | MRI Analysis: Optimization of parameters for diffusion MRI to enhance hippocampal subfield analysis and segmentation (Preliminary Data) |
| title_fullStr | MRI Analysis: Optimization of parameters for diffusion MRI to enhance hippocampal subfield analysis and segmentation (Preliminary Data) |
| title_full_unstemmed | MRI Analysis: Optimization of parameters for diffusion MRI to enhance hippocampal subfield analysis and segmentation (Preliminary Data) |
| title_short | MRI Analysis: Optimization of parameters for diffusion MRI to enhance hippocampal subfield analysis and segmentation (Preliminary Data) |
| title_sort | mri analysis optimization of parameters for diffusion mri to enhance hippocampal subfield analysis and segmentation preliminary data |
| topic | Hippocampus Neuroimaging IQT Neuroscience |
| url | https://www.cambridge.org/core/product/identifier/S0924933822016376/type/journal_article |
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