High Neutrophil-lymphocyte Ratio Predicts Serious Renal Insufficiency in Patients with Lupus Nephritis
Background: Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE).The neutrophil to lymphocyte ratio (NLR) is a promising predictor and prognostic factor. An increased NLR is associated with a poor prognosis of several inflammatory diseases. Objective:...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2022-03-01
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| Series: | Iranian Journal of Immunology |
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| Online Access: | https://iji.sums.ac.ir/article_48263_4159fcc7d5ea0db6459c93b097b5a550.pdf |
| _version_ | 1811271551772786688 |
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| author | Dijiao Tang Qi Tang Long Zhang Hongxu Wang |
| author_facet | Dijiao Tang Qi Tang Long Zhang Hongxu Wang |
| author_sort | Dijiao Tang |
| collection | DOAJ |
| description | Background: Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE).The neutrophil to lymphocyte ratio (NLR) is a promising predictor and prognostic factor. An increased NLR is associated with a poor prognosis of several inflammatory diseases. Objective: To evaluate the value of NLR in the diagnosis and pre-assessment of the disease severity of LN. Methods: This retrospective study included 88 patients with LN, 51 SLE patients without kidney involvement, 79 patients with primary chronic nephritis (CN), and 52 healthy controls (HC). The differences among these four groups and diagnostic value of NLR for patients with LN were evaluated. Results: The NLR of patients with LN before treatment was significantly higher than that of the other three groups. NLR positively correlated with C-reactive protein (CRP), complement 3(C3), C4, and serum creatinine (SCr) (CRP: r=0.337, p=0.007; C3: r=0.222, p=0.042; C4: r=0.230, p=0.035; SCr: r=0.408, p <0.0001) but negatively correlated with total serum IgG (r=-0.226, p=0.041). The level of NLR increased with the severity of renal dysfunction NLR (area under the curve: 0.785, 95% CI: 0.708-0.862) was useful for the diagnosis of LN, and its optimal cut-off value was 5.44 (sensitivity: 65.9%, specificity: 86.3%). Conclusions: NLR would be useful for the diagnosis of LN and reflects the severity of renal dysfunction Therefore, evaluating NLR before treatment could help clinicians to identify potential renal involvement in patients with SLE and distinguish LN from CN. |
| first_indexed | 2024-04-12T22:23:06Z |
| format | Article |
| id | doaj.art-958696462e8e43bca511d9366193bffc |
| institution | Directory Open Access Journal |
| issn | 1735-1383 1735-367X |
| language | English |
| last_indexed | 2024-04-12T22:23:06Z |
| publishDate | 2022-03-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Immunology |
| spelling | doaj.art-958696462e8e43bca511d9366193bffc2022-12-22T03:14:17ZengShiraz University of Medical SciencesIranian Journal of Immunology1735-13831735-367X2022-03-01191495710.22034/iji.2022.92554.215448263High Neutrophil-lymphocyte Ratio Predicts Serious Renal Insufficiency in Patients with Lupus NephritisDijiao Tang0Qi Tang1Long Zhang2Hongxu Wang3Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.Department of Clinical Laboratory, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.Department of Urinary Surgery, People’s Hospital of Jiulongpo District, Chongqing, China.Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.Background: Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE).The neutrophil to lymphocyte ratio (NLR) is a promising predictor and prognostic factor. An increased NLR is associated with a poor prognosis of several inflammatory diseases. Objective: To evaluate the value of NLR in the diagnosis and pre-assessment of the disease severity of LN. Methods: This retrospective study included 88 patients with LN, 51 SLE patients without kidney involvement, 79 patients with primary chronic nephritis (CN), and 52 healthy controls (HC). The differences among these four groups and diagnostic value of NLR for patients with LN were evaluated. Results: The NLR of patients with LN before treatment was significantly higher than that of the other three groups. NLR positively correlated with C-reactive protein (CRP), complement 3(C3), C4, and serum creatinine (SCr) (CRP: r=0.337, p=0.007; C3: r=0.222, p=0.042; C4: r=0.230, p=0.035; SCr: r=0.408, p <0.0001) but negatively correlated with total serum IgG (r=-0.226, p=0.041). The level of NLR increased with the severity of renal dysfunction NLR (area under the curve: 0.785, 95% CI: 0.708-0.862) was useful for the diagnosis of LN, and its optimal cut-off value was 5.44 (sensitivity: 65.9%, specificity: 86.3%). Conclusions: NLR would be useful for the diagnosis of LN and reflects the severity of renal dysfunction Therefore, evaluating NLR before treatment could help clinicians to identify potential renal involvement in patients with SLE and distinguish LN from CN.https://iji.sums.ac.ir/article_48263_4159fcc7d5ea0db6459c93b097b5a550.pdflupus nephritisneutrophil-lymphocyte ratiorenal insufficiencysystemic lupus erythematosus |
| spellingShingle | Dijiao Tang Qi Tang Long Zhang Hongxu Wang High Neutrophil-lymphocyte Ratio Predicts Serious Renal Insufficiency in Patients with Lupus Nephritis Iranian Journal of Immunology lupus nephritis neutrophil-lymphocyte ratio renal insufficiency systemic lupus erythematosus |
| title | High Neutrophil-lymphocyte Ratio Predicts Serious Renal Insufficiency in Patients with Lupus Nephritis |
| title_full | High Neutrophil-lymphocyte Ratio Predicts Serious Renal Insufficiency in Patients with Lupus Nephritis |
| title_fullStr | High Neutrophil-lymphocyte Ratio Predicts Serious Renal Insufficiency in Patients with Lupus Nephritis |
| title_full_unstemmed | High Neutrophil-lymphocyte Ratio Predicts Serious Renal Insufficiency in Patients with Lupus Nephritis |
| title_short | High Neutrophil-lymphocyte Ratio Predicts Serious Renal Insufficiency in Patients with Lupus Nephritis |
| title_sort | high neutrophil lymphocyte ratio predicts serious renal insufficiency in patients with lupus nephritis |
| topic | lupus nephritis neutrophil-lymphocyte ratio renal insufficiency systemic lupus erythematosus |
| url | https://iji.sums.ac.ir/article_48263_4159fcc7d5ea0db6459c93b097b5a550.pdf |
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