Anticancer Activity of the Acetylenic Derivative of Betulin Phosphate Involves Induction of Necrotic-Like Death in Breast Cancer Cells In Vitro

Anticancer Activity of the Acetylenic Derivative of Betulin Phosphate Involves Induction of Necrotic-Like Death in Breast Cancer Cells In Vitro

Betulin (BT) is a natural pentacyclic lupane-type triterpene exhibiting anticancer activity. Betulin derivatives bearing propynoyloxy and phosphate groups were prepared in an effort to improve the availability and efficacy of the drug. In this study, a comparative assessment of the in vitro anticanc...

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Bibliographic Details
Main Authors: Arkadiusz Orchel, Ewa Chodurek, Marzena Jaworska-Kik, Piotr Paduszyński, Anna Kaps, Elwira Chrobak, Ewa Bębenek, Stanisław Boryczka, Paulina Borkowska, Janusz Kasperczyk
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
betulin
cytotoxicity
apoptosis
regulated necrosis
breast cancer
Online Access:https://www.mdpi.com/1420-3049/26/3/615

Internet

https://www.mdpi.com/1420-3049/26/3/615

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